Flavonoids and other constituents with insulin secretion activity from Pseudarthria hookeri

Tchamgoue, Joseph; Hafizur, Rahman M.; Tchouankeu, Jean Claude; Kouam, Siméon F.; Adhikari, Achyut; Hameed, Abdul; Green, Ivan R.; Choudhary, M. Iqbal

doi:10.1016/j.phytol.2016.07.015

Cited by 14 publications

(7 citation statements)

References 24 publications

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“…[ 25 ]. Similarly, Pseudarthria hookeri Wight and Arn which has been used as traditional herbal medicine in Africa [ 26 , 27 ] for the treatment of pneumonia, abdominal pains, cough and diarrhea. According to the antibacterial study of this medicinal species, Dzoyem and his team found that flavonoids from this plant showed the highest antibacterial effect against both gram-positive and gram-negative bacteria e.g., E. coli , Klebsiella pneumonia (Schroeter) Trevisan, Pseudomonas aeruginosa (Schroeter) Migula, Enterococcus faecalis (Andrew and Horder) Schleifer and Kilpper-Blazand, and Staphylococcus aureus Rosenbach; the highest antibacterial activities found in pseudarflavone A and 6-prenylpinocembrin [ 27 ].…”

Section: Effects Of Plant Flavonoids and Other Phenolics On Human mentioning

confidence: 99%

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

et al. 2018

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Phenolic compounds as well as flavonoids are well-known as antioxidant and many other important bioactive agents that have long been interested due to their benefits for human health, curing and preventing many diseases. This review attempts to demonstrate an overview of flavonoids and other phenolic compounds as the interesting alternative sources for pharmaceutical and medicinal applications. The examples of these phytochemicals from several medicinal plants are also illustrated, and their potential applications in pharmaceutical and medical aspects, especially for health promoting e.g., antioxidant effects, antibacterial effect, anti-cancer effect, cardioprotective effects, immune system promoting and anti-inflammatory effects, skin protective effect from UV radiation and so forth are highlighted.

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Section: Effects Of Plant Flavonoids and Other Phenolics On Human mentioning

confidence: 99%

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

et al. 2018

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“…However, despite the widespread use of this plant in traditional medicine to treat malaria, no previous research has focused on its antiplasmodial capabilities. The isolation and characterization of flavonoids from this plant's CH 2 Cl 2 /MeOH (1:1) extract were previously reported in a prior study by the same group (Tchamgoue et al, 2016). Some of the isolated flavonoids have been shown to have promising antimalarial effects in vitro, according to the literature (Ajaiyeoba et al, 2008;Attioua et al, 2011;Kraft et al, 2000;Lehane & Saliba, 2008;Nogueira & Lopes, 2011).…”

Section: Introductionmentioning

confidence: 74%

“…After filtering the solution, the solvent was removed under vacuum, yielding 310.6 g of crude extract (a greenish solid). To obtain the evaluated compounds, 300 g of the crude extract was subjected to successive column chromatography (Tchamgoue et al, 2016). A part of this greenish solid (10.0 g) was extracted with n-hexane (100 mL), the insoluble portion was taken up in ethyl acetate and methanol (100 mL/each), respectively.…”

Section: Plant Materials and Compounds Isola Onmentioning

confidence: 99%

In vivo antiplasmodial properties of fractions and flavonoids of Pseudarthria hooheri Wight & Arn. (Fabaceae)

Tchamgoue¹,

Eyado²,

Boniface³

et al. 2022

NRFHH

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Malaria is regarded as one of the most lethal diseases. Resistance to artemisinin and its derivatives jeopardises effective malaria treatment. Finding novel antimalarial chemicals is critical given the existing treatment situation. This work aimed to examine the antiplasmodial capabilities of Pseudarthria hookeri fractions and flavonoids in vivo. The fractions and compounds antiplasmodial activity were evaluated on male Swiss albino mice infected with Plasmodium berghei, and on healthy female Swiss albino mice, the crude extract's acute toxicity was assessed. The EtOAc fraction had significant antiplasmodial activity (32.53 percent suppression at 500 mg/kg BW) and considerably prolonged the survival period of infected mice (9.8 days) compared to control mice (7.8 days). Parasitaemia was dramatically reduced (85.01, 59.41, and 70.39 percent), and the mean survival time extended (11.33, 10.00, and 9.33 days) with 15, 20 and 35 mg/kg of quercetin (1), 7-O-benzyl-6-prenylpinocembrin (6) and 6,8-diprenyleriodictyol (11) (isolates of the EtOAc fraction), respectively. BW loss and PCV reduction were also averted. Moreover, at 2500 mg/kg, the crude extract of P. hookeri showed no acute toxicity in mice. LC-MS analysis of the EtOAc fraction enabled the identification of nine flavonoids, with 8 and 11 being the main components. The present investigation confirmed P. hookeri's antiplasmodial action, substantiating its ethnomedicinal application for malaria treatment.

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“…Concerning our previous chemotaxonomic studies on this plant species, we also reported that lignans and flavonoids could be considered as chemotaxonomic markers for the genus. In continuation of our search for bioactive compounds from Cameroonian medicinal plants [13][14][15], we have investigated the bark of D. staudtii for its minor secondary metabolites. Herein, we report the bioassay-guided fractionation, as well as the structural elucidation of a new flavone and the antifilarial activities of the selected isolated compounds.…”

Section: Introductionmentioning

confidence: 99%

Pachypodostyflavone, a New 3-methoxy Flavone and Other Constituents with Antifilarial Activities from the Stem Bark of Duguetia staudtii

Mbobda

Ngouonpe

Happi

et al. 2021

Planta Medica International Open

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A new flavone derivative named pachypodostyflavone (1), along with 8 known compounds (2–9) and a mixture of β-sitosterol and stigmasterol were isolated from the stem bark of Duguetia staudtii (Annonaceae), based on a bioassay-guided fractionation. Their structures were determined using high-resolution mass spectrometry and NMR spectroscopic data, as well as by comparison with the literature values of their analogs. Selected isolated compounds were evaluated for their in vitro antifilaricidal activities on Onchocerca ochengi microfilariae and adult worms. Inhibition of motility was evaluated spectroscopically on microfilaria and adult male worms. Viability was determined on adult female worms by the MTT/ Formazan assay. Auranofin at 10 µM and 2% DMSO were used as positive and negative controls, respectively. Compounds 1 and 7 showed potent anti-onchocerca activities with 100% activity at 250 µg/mL on both O. ochengi adult male and female worms, while compound 5 displayed 100% activity at 30 µg/mL.

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Flavonoids and other constituents with insulin secretion activity from Pseudarthria hookeri

Cited by 14 publications

References 24 publications

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview

<i>In vivo</i> antiplasmodial properties of fractions and flavonoids of <i>Pseudarthria hooheri</i> Wight & Arn. (Fabaceae)

Pachypodostyflavone, a New 3-methoxy Flavone and Other Constituents with Antifilarial Activities from the Stem Bark of Duguetia staudtii

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