Flavonoids and gastrointestinal health: single molecule for multiple roles

Lan, Haijing; Wang, Hui; Chen, Chong; Hu, Weicheng; Ai, Chao; Chen, Lei; Teng, Hui

doi:10.1080/10408398.2023.2230501

Cited by 18 publications

(5 citation statements)

References 195 publications

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“…Preventing atherosclerosis, lowering cholesterol levels, cardiovascular prevention, and providing radiation protection are related to polyphenol enrichment [6][7][8][9][10][11][12]. Mulberries contain a significant amount of polysaccharides, which serve as important functional factors with high biological activity [3,13].…”

Section: Introductionmentioning

confidence: 99%

Enhanced DPPH Radical Scavenging Activity and Enriched γ-Aminobutyric Acid in Mulberry Juice Fermented by the Probiotic Lactobacillus brevis S3

Gong,

Li,

Feng

et al. 2023

Fermentation

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Mulberries, known for their high sugar content and rich bioactive compounds, have attracted attention for their potential health benefits. γ-Aminobutyric acid (GABA) is an amino acid with multiple physiological functions. To increase the GABA content and enhance the antioxidant capacity in fermented mulberry beverages, we screened a high-yielding strain, Lactobacillus brevis S3, known for its probiotic properties. L. brevis S3 demonstrated an excellent tolerance to simulated gastric acid, gastric juice, intestinal fluid, bile salts, osmotic pressure, and phenol, making it a safe and valuable probiotic candidate for mulberry fermentation. We attempted the addition of different nutritional components to enhance the GABA content in mulberry juice, including 1% yeast extract; 0.5% peptone; 0.01% metal ion complex (magnesium sulfate, manganese sulfate, and ferrous sulfate); combinations of yeast extract and peptone, and all three components. Mulberry juice supplemented with all three components reached a viable cell count of 1.2 × 1010 CFU/mL after 72 h. The antioxidant capacity and GABA titer were enhanced. The DPPH free radical scavenging capacity increased by 1.62 times, and the GABA content reached 7.48 g/L. By utilizing L. brevis S3 with excellent probiotic properties and supplementation with nutritional components, it is possible to produce low-sugar mulberry functional beverages with a high DPPH free radical scavenging capacity that are rich in GABA.

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Section: Introductionmentioning

confidence: 99%

Enhanced DPPH Radical Scavenging Activity and Enriched γ-Aminobutyric Acid in Mulberry Juice Fermented by the Probiotic Lactobacillus brevis S3

Gong,

Li,

Feng

et al. 2023

Fermentation

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“…Plant-based polyphenols undergo metabolization and biotransformation during gastrointestinal digestion, and through their interaction with the gut microbiota. Polyphenols and their metabolites then exert several effects on the human gastrointestinal tract, including the modulation of gut microbiota, the improvement of the intestinal barrier, and a reduction in inflammation and oxidative stress [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Khalil,

Piccapane,

Vacca

et al. 2024

Nutrients

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(Poly)phenolic-rich Mediterranean plants such as Thymbra spicata have been associated with several health-promoting effects. The nutritional value, as well as physiological interaction of T. spicata with the gastrointestinal tract, has not been investigated before. The nutritional composition of T. spicata leaves was here characterized by standard analytical methods. T. spicata leaves were subjected to ethanolic extraction, simulated gastrointestinal digestion, and anaerobic microbial gut fermentation. Phenols/flavonoid contents and radical scavenging activity were assessed by colorimetric methods. The volatile organic compounds (VOCs) were detected by gas chromatography coupled with mass spectrometry. The effect on intestinal integrity was evaluated using a Caco-2 monolayers mounted in a Ussing chamber. T. spicata contains a high amount of fiber (12.3%) and unsaturated fatty acids (76% of total fat). A positive change in VOCs including short-chain fatty acids was observed without significant change in viable microbe. T. spicata and carvacrol (main phenolic compound) enhanced ionic currents in a concentration-dependent manner without compromising the Caco-2 monolayer’s integrity. These effects were partially lost upon simulated digestion and completely abolished after colonic fermentation in line with polyphenols and carvacrol content. Conclusion: T. spicata represents a promising nutrient for the modulation of gut microbiota and the gut barrier. Further studies must better define its mechanisms of action.

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“…They have different phenolic structures consisting of two benzene rings with phenolic hydroxyl groups, primarily in glycosidic and free forms. These compounds exhibit antioxidative, anti-inflammatory ( Guo et al, 2023c ), antimicrobial, anti-apoptotic, neovascularization inhibiting, and central nervous and cardiovascular system protective effects ( Lan et al, 2023a ). Typically, flavonoid glycosides contain glucose bonds.…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 99%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes in the composition, abundance, and diversity of the gut microbiota (GM). Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component and multi-target advantages, can help treat AMD by altering GM composition and regulating the levels of certain substances, such as lipopolysaccharides, reducing oxysterols, and increasing SCFA and BA contents. This review explores the correlation between GM and AMD and interventions for the two to provide new perspectives on treating AMD with TCM.

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Flavonoids and gastrointestinal health: single molecule for multiple roles

Cited by 18 publications

References 195 publications

Enhanced DPPH Radical Scavenging Activity and Enriched γ-Aminobutyric Acid in Mulberry Juice Fermented by the Probiotic Lactobacillus brevis S3

Enhanced DPPH Radical Scavenging Activity and Enriched γ-Aminobutyric Acid in Mulberry Juice Fermented by the Probiotic Lactobacillus brevis S3

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

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