Flavonoids and alkaloids from the rhizomes of Zephyranthes ajax Hort. and their cytotoxicity

Nguyen, Khan Viet; Ho, Duc Viet; Le, Nhan Trong; Phan, Kiem Van; Heinämäki, Jyrki; Raal, Ain; Nguyen, Hoai Thi

doi:10.1038/s41598-020-78785-2

Cited by 9 publications

(4 citation statements)

References 29 publications

(23 reference statements)

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“…Ajax Hort. collected in Vietnam (Nguyen et al 2020). Maceration of bulbs in MeOH (5.5 kg; it is not clear whether they were dried or fresh) gave 467 g of extract, which was further subjected to LLE.…”

Section: Phytochemical Studies Of Zephyranthes Roseamentioning

confidence: 99%

Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry

Šafratová,

Vrabec,

Blunden

et al. 2024

Phytochem Rev

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This article is a critical review of the taxonomy and phytochemistry of the genus Zephyranthes Herb., a group of plants known for their beautiful flowers and traditional medicinal uses. The present review summarizes the occurrence, isolation, and identification of specialized metabolites, which have recently been frequently studied because of their important biological activities. Among the accepted 203 species, only 27 have been phytochemically investigated. This paper provides an overview of the different types of specialized metabolites identified in these plants and considers problematic taxonomic evolution within this species. The differences between two internationally recognized databases, which classify only 41% of the species in the same way, are briefly summarized. In addition, there are many reports on their metabolites, especially alkaloids, but some of the data in the literature are occasionally inaccurate and sometimes even erroneous. This critical review aims to discuss, summarize, and evaluate up-to-date (up to July of 2023) information about metabolites of the genus Zephyranthes, focusing on phytochemistry and taxonomy. Graphical abstract

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Section: Phytochemical Studies Of Zephyranthes Roseamentioning

confidence: 99%

Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry

Šafratová,

Vrabec,

Blunden

et al. 2024

Phytochem Rev

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“…The cytotoxic evaluation of 1-7 and ellipticine against the growth of human epidermoid carcinoma (KB), human hepatocellular carcinoma (Hep G2), and human breast adenocarcinoma (MCF-7) cell lines was performed according to a previous procedure [32]. Ellipticine, a potent anticancer agent exhibiting multiple mechanisms of action, was used as the positive control [33][34][35]. The cancer cells were cultured in Dulbecco's Modified Eagle's Medium with 10% Fetal Bovine Serum, 1% penicillin and streptomycin, and 1% L-glutamine at 37 • C in a 5% CO 2 environment.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

New Flavonoid Derivatives from Melodorum fruticosum and Their α-Glucosidase Inhibitory and Cytotoxic Activities

Lien

Sichaem

2022

Molecules

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Three new flavonoid derivatives, melodorones A–C (1–3), together with four known compounds, tectochrysin (4), chrysin (5), onysilin (6), and pinocembrin (7), were isolated from the stem bark of Melodorum fruticosum. Their structures were determined on the basis of extensive spectroscopic methods, including NMR and HRESIMS, and by comparison with the literature. Compounds 1–7 were evaluated for their in vitro α-glucosidase inhibition and cytotoxicity against KB, Hep G2, and MCF7 cell lines. Among them, compound 1 exhibited the best activity against α-glucosidase and was superior to the positive control with an IC50 value of 2.59 μM. On the other hand, compound 1 showed moderate cytotoxicity toward KB, Hep G2, and MCF7 cell lines with the IC50 values of 23.5, 19.8, and 23.7 μM, respectively. These findings provided new evidence that the stem bark of M. fruticosum is a source of bioactive flavonoid derivatives that are highly valuable for medicinal development.

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“…The study of alkaloids in members of the genus Zephyranthes is relevant (Centeno-Betanzos et al, 2021;Kohelová et al, 2021), in particular in Z. candida Zhan et al, 2017;Murphy et al, 2020), flavans with potential anti-inflammatory activities from Z. candida Nguyen et al, 2020), chlorotic ringspot virus infecting Z. candida in China (Wu & Liu, 2017), the endosperm development and the variations of structures of embryo sacs (Chengqi, 2019).…”

Section: Introductionmentioning

confidence: 99%

Micromorphology and anatomy of the flower of Zephyranthes candida (Amaryllidaceae)

Fishchuk

2021

Regul. Mech. Biosyst.

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The use of morphological features of flowers in the taxonomy of plants is becoming increasingly important. The structure of the Zephyranthes candida (Lindl.) Herb. flowers on permanent cross-sectional and longitudinal sections was studied using a light microscope. The genus Zephyranthes belongs to the subtribe Hippeastrinae Walp. tribe Hippeastreae Sweet., family Amaryllidaceae s.l. Microscopic studies of the flower are considered as a tool to identify hitherto unknown structural adaptations of plants to specialized pollination methods and to elucidate the first stages of fruit morphogenesis, as many features of the fruit appear at the flower stage. The morphometric parameters, morphology, anatomy, and vascular anatomy of the ovary were described by using the flower’s transverse sections. Ten flowers of Z. candida were sectioned using standard methods of Paraplast embedding and serial sectioning at 20 μm thickness. Sections were stained with Safranin and Astra Blau and mounted in Eukitt. It was found that in the studied species the tepals have multi-bundle traces of 10–12 leading bundles. We consider the gynoecium of the studied species to be eusincarpous. The vascular system of the inferior ovary consists of three dorsal and three septal bundles, paired ventral bundles of carpels, which form ovule traces. For the first time, the presence of the following gynoecium zones was detected: a synascidiate structural zone with a height of about 360 μm and a fertile symplicate structural zone with a height of about 1560 μm and a hemisymplicate zone of 480 μm. Septal nectaries appear in the hemisymplicate zone and open with nectary split at the base of the style, the total height of the septal nectary is 760 μm. The ovary roof is 280 μm. Bifurcated dorsal and septal bundles of carpels have been identified, which can be considered as adaptations of the early stages of fruit morphogenesis to opening. Anatomical features of the ovary of Z. candida are numerous vascular bundles in the pericarpium, non-lignified endocarp at the flower stage, we consider as adaptations to the formation of juicy fruit. New data on the anatomical structure of the flower are a significant addition to the information on antecological and post-anthetic features of the studied species. Also, these data can be used in the construction of parsimony branches of the family Amaryllidaceae.

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Flavonoids and alkaloids from the rhizomes of Zephyranthes ajax Hort. and their cytotoxicity

Cited by 9 publications

References 29 publications

Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry

Specialized metabolites of the genus Zephyranthes Herb.: a critical review on taxonomy and phytochemistry

New Flavonoid Derivatives from Melodorum fruticosum and Their α-Glucosidase Inhibitory and Cytotoxic Activities

Micromorphology and anatomy of the flower of Zephyranthes candida (Amaryllidaceae)

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