Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs

Abstract

Purpose: This study aimed to assess the potential of flavonoids in combating CIPN. Methods: PubMed and Google Scholar were used, and studies that investigated flavonoids in models of CIPN and models of neuropathic pain similar to CIPN were included. Only studies investigating peripheral mechanisms of CIPN were used. Results: Flavonoids inhibit several essential mechanisms of CIPN, such as proinflammatory cytokine release, astrocyte and microglial activation, oxidative stress, neuronal damage and apoptosis, mitochondrial damage, ectopic discharge, and ion channel activation. They decreased the severity of certain CIPN symptoms, such as thermal hyperalgesia and mechanical, tactile, and cold allodynia. Conclusions: Flavonoids hold immense promise in treating CIPN; thus, future research should investigate their effects in humans. Specifically, precise pharmacological mechanisms and side effects need to be elucidated in human models before clinical benefits can be achieved.

Protective effect of naringin against oxaliplatin‐induced peripheral neuropathy in rats: A behavioral and molecular study

“…[35,36] Based on this theory, numerous chemicals and nutraceuticals with antioxidant activity have been examined in vivo studies and clinical trials to evaluate their efficiency toward peripheral neurotoxicity triggered by chemotherapeutics. [37][38][39][40] Neurodegeneration resulted from oxidative damage could occur due to bio-energetic failure, biomolecular damage, or weakening of antioxidant defence mechanisms. [41] Considering the ameliorative effects of several antioxidant molecules against chemotherapeutics-induced peripheral neuropathy, NRG was tested in the current study as a potent antioxidant.…”

The anti-inflammatory properties of the methanolic extract of Cucumis melo Linn. against prostate enlargement in Wistar rats

“…The glands became less in number and lining epithelium became flattened in the standard drug-treated group. Hyperplasia of prostatic epithelial cells and stromal cells occurs, which subsequently results in lower urinary tract symptoms ( Jin et al, 2021 , Zhang et al, 2021 , Siddiqui et al, 2021 ).…”

Investigation of the key targets and pharmacological mechanisms of rhamnocitrin against oxaliplatin-induced neuropathic pain based on network pharmacology approach and experimental validation

“…Besides, there was currently no effective treatment to control oxaliplatin-induced NP optimally. Previous reports indicated that flavonoids could prevent the occurrence and development of chemotherapy-induced NP via suppressing apoptosis, oxidative stress, astrocyte and microglial activation, and inflammatory responses (Zhang Singh et al 2020;Xie et al 2020;Siddiqui et al 2021). Therefore, flavonoids may be a novel analgesic drug in the prevention and treatment of chemotherapy-induced NP.…”