Flavonoides do Gênero Annona

Almeida, Anderson Soares de; Santos, Aldenir Feitosa dos

doi:10.17648/diversitas-journal-v3i2.583

Cited by 3 publications

(4 citation statements)

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“…This is the first report of the use of chemophenetics (specifically alkaloids and leaf volatiles) to differentiate morphological variations of Annona emarginata . The only previous report found with the genus Annona was the report by de Almeida et al ., [27] in which the effectiveness of using flavonoids as chemophenetic markers of the genus Annona was demonstrated.…”

Section: Resultsmentioning

confidence: 98%

Chemophenetics as a Tool for Distinguishing Morphotypes of Annona emarginata (Schltdl.) H. Rainer

Mimi

De-la-Cruz-Chacón

Sousa

et al. 2021

Chemistry & Biodiversity

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Annona emarginata (Annonaceae) has two morphological variations (A. emarginata ‘mirim’ and A. emarginata ‘terra‐fria’). The species has agricultural value and produces specialized metabolites of pharmacological interest. The objective of this work was to analyze whether chemical and morphological differences contribute to differentiate A. emarginata ‘terra‐fria’ from A. emarginata ‘mirim’, as chemophenetic variations of A. emarginata. The analysis of chemical compounds was based on the quantification, profile of root alkaloids and on the leaves volatile profile, together with morphometric analyses of the leaf blade. The samples were collected in three phenological stages (flowering, fruiting, and vegetative) at two places in São Paulo, Brazil. Differences in the composition of the alkaloid profile and leaf volatiles (in both places and in the three phenological stages) allowed us to separate the two morphotypes by multivariate statistical analysis. These differences agreed with the leaf blade morphology and flower color. This first chemophenetic report of A. emarginata demonstrates that, in addition to morphological variations, the specialized metabolism of roots and leaves can be phytochemical characters, which suggest the existence of at least morphochemotypes of A. emarginata.

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Section: Resultsmentioning

confidence: 98%

Chemophenetics as a Tool for Distinguishing Morphotypes of Annona emarginata (Schltdl.) H. Rainer

Mimi

De-la-Cruz-Chacón

Sousa

et al. 2021

Chemistry & Biodiversity

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“…It is noteworthy that flavonoids are polyphenols present in several plants, where more than 8,000 metabolites have already been identified. They have in their composition a common flavilum nucleus of phenylchromanoma, containing 15 carbons distributed in two aromatic rings (rings A and B), the benzenes, interconnected to a central heterocyclic structure, the pyran (ring C), where the first benzene is condensed with the sixth carbon of the pyran, which in position 2 carries a phenyl group (Almeida & Santos, 2018), with substitution in one or more hydroxyls, including those linked to sugars (glycosides).…”

Section: Introductionmentioning

confidence: 99%

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

Ferreira,

Crispim,

Aguiar

et al. 2024

RSD

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Cupuaçu (Theobroma grandiflorum) from the Malvaceae family, has seeds rich in flavonoids. The biological activities of seeds are diverse, however, there are scarce data on these metabolites. The study aimed to evaluate, through in silico methods, the biological, toxicological, and pharmacokinetic potential of metabolites present in the cupuaçu seed. The metabolites hypolaetina 3'-methylether 8-O-β-D glucuronide, theograndin II, hypolaetina 3'-methylether 8-O-β-D 3”-sulfated glucuronide, isoscutellarein 8-0-β-D glucuronide and theograndin I were analysed through Pubchem to search for structures, and PreADMET (pharmacokinetics and toxicity) and PASS online for biological activities (PA >98%). The results demonstrated low human intestinal absorption, in addition to weak to moderate distribution across the blood-brain barrier. All phenolic compounds showed weak to moderate binding to plasma proteins and low permeability in CaCo2 cells, except for isoscutelarein 8-0-β-D glucuronide and hypolaetina 3'-methylether 8-O-β-D glucuronide with moderate permeability, being non-mutagenic. Furthermore, they had the potential to inhibit CYPs, such as CYP-2C9 and CYP-3A4. Also, the structures showed toxicity in Medaka fish, but they did not present toxicity in algae and Daphnia sp. Finally, the molecules presented the following main properties: hemostatic, cardioprotective, and antioxidant action, among others. The compounds presented varied biological activity profiles, but their pharmacokinetic and toxicity were not promising, limiting the potential for developing new drugs. The use of technologies is suggested to transform them into prodrugs, carriers, and the use of molecular modeling.

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“…Flavonoids are part of the most relevant and diversified group of phenolic compounds among natural products [ 63 ] and are widely distributed in the plant kingdom [ 64 , 65 ]. They stand out for having great economic attractiveness due to their various properties beneficial to health [ 66 ].…”

Section: Introductionmentioning

confidence: 99%

“…These compounds belong to an important class of secondary metabolites [ 68 ], in addition to having the virtue of their wide variety of biological and therapeutic activities, demonstrated both in vitro and in vivo [ 65 ]. We can thus highlight the correlation of these compounds with antioxidant, anti-inflammatory, antitumor, and antiviral properties, among others [ 60 ].…”

Section: Introductionmentioning

confidence: 99%

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

Ramos

Mazzinghy

Correia

et al. 2022

Plants

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The Annonaceae family is widely distributed in subtropical and tropical regions. Several species of this family are known for their pharmacological and beneficial properties to human health, mainly attributed to flavonoids. The objective of this work was to carry out an integrative review in order to identify the main flavonoids found in some plant parts belonging to the Annona genus: araticum tree (Annona crassiflora Mart.), graviola tree (Annona muricata), atemoya tree (Annona cherimolia Mill × Annona squamosa L.), pinha tree (Annona squamosa), bananinha tree (Annona leptopetala), and marolinho tree (Annona coriacea). Only articles published between the years 2016 to 2021 that answered the guiding question were considered, in order to obtain recent data. Then, search strategies were designated for each database used: Science Direct, CAPES Periodicals, and Scielo. Most of the studies retrieved from the databases are related to fruits. The results showed that the number of flavonoids identified varies according to the analytical methodology used to identify and quantify the compounds. Quercetin was the most commonly found compound in all fruits of the Annona genus studied, and epicatechin, rutin, and kaempferol were also found to a lesser extent. The presence of these compounds in Annona makes the fruit promising, with potential applicability in the pharmaceutical and food industry.

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Flavonoides do Gênero Annona

Abstract: Todo o conteúdo expresso neste artigo é de inteira responsabilidade dos seus autores.

Cited by 3 publications

References 8 publications

Chemophenetics as a Tool for Distinguishing Morphotypes of Annona emarginata (Schltdl.) H. Rainer

Chemophenetics as a Tool for Distinguishing Morphotypes of Annona emarginata (Schltdl.) H. Rainer

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

An Integrative Approach to the Flavonoid Profile in Some Plants’ Parts of the Annona Genus

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