Flavonoid-Rich Alcoholic Extract of Leaves of Achyranthes Aspera Reduces Inflammation in a Murine Model of Ova-Induced Asthma

Kandasamy, Ruckmani; Hellermann, Gary; Mohapatra, Subhra; Lockey, R.F.

doi:10.1016/j.jaci.2011.12.614

Cited by 3 publications

(4 citation statements)

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“…This is likely to be caused by its content in flavonoids as it has been reported by Güler ( 2013 ) and Kandasamy et al. ( 2012 ). Actually, in the present study, it is reported that our nettle extract was not only rich in phenolic compounds, but also had a significant antioxidant potential, hence the importance to complete our investigation by studying its effect on oxidative stress generated by the inhalation of the allergen, and participates in turn exacerbate bronchial inflammation.…”

Section: Resultsmentioning

confidence: 64%

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Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model

Zemmouri

Sekiou

Ammar

et al. 2017

Pharmaceutical Biology

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Context: To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use.Objective: In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract.Materials and methods: Adult male Wistar rats were divided into four groups: Group I: negative control; group II: Ovalbumin sensitized/challenged rats (positive control); group III: received UD extract (1.5 g/kg/day) orally along the experimental protocol; group IV: received UD extract (1.5 g/kg/day) orally along the experimental protocol and sensitized/challenged with ovalbumin. After 25 days, blood and tissue samples were collected for haematological and histopathological analysis, respectively. The oxidative stress parameters were evaluated in the lungs, liver and erythrocytes. Then, correlations between markers of airway inflammation and markers of oxidative stress were explored.Results: UD extract significantly (p < 0.01) inhibited eosinophilia increases in BALF (−60%) and the levels of leucocytes (−32.75%) and lymphocytes (−29.22%) in serum, and effectively suppressed inflammatory cells recruitment in the asthmatic rat model. Besides, the lipid peroxidation generated by allergen administration was significantly (p < 0.05) diminished by UD treatment in lung tissue (−48.58%). The nettle extract was also investigated for the total phenolic content (30.79 ± 0.96 mg gallic acid/g dry extract) and shows DPPH radical scavenging activity with 152.34 ± 0.37 μg/mL IC50 value.Conclusions: The results confirmed that UD administration might be responsible for the protective effects of this extract against airway inflammation.

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Section: Resultsmentioning

confidence: 64%

“… 1999 ), which was attributed by Kandasamy et al. ( 2012 ) to the anti-asthmatic activity of flavonoids. In fact, several other studies on bioactive molecules have suggested that chrysin reduces the infiltration of inflammatory cells in a murine asthma model by restoring the balance Th1/Th2 (Pankaj et al.…”

Section: Resultsmentioning

confidence: 90%

Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model

Zemmouri

Sekiou

Ammar

et al. 2017

Pharmaceutical Biology

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“…This may be due to the protective effects of antioxidant molecules, present in the aqueous extract of Chamaemelum nobile such as phenolic compounds (flavonoids). The latter has the ability to scavenge free radicals and protect cells against oxidative stress (Kandasamy et al (50) speculate that the antiasthmatic activity of flavonoids is likely due to inhibition of the transcription factor NF-Kβ. Indeed, several other studies have reported the beneficial effect of phenolic compounds on asthmatic symptoms.…”

Section: Discussionmentioning

confidence: 99%

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

Mustapha Hichem Zadam,

Meriem Ahmida,

Nesrine Djaber

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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The aim of our study is to evaluate anti-inflammatory effect of Chamaemelum nobile. Aqueous extracts were administrated to Wistar rats in bronchial-inflammation experimentally induced by an allergen and ovalbumin, administered intraperitoneally / intranasally (20mg/kg/day). Experimentation showed disturbances in bronchoalveolar fluid with increased leukocyte and lymphocyte levels as well as IL-4 concentration in the lungs and erythrocytes associated with high lipid peroxidation. There were disturbances in enzymatic and non-enzymatic antioxidant defense system. Lungs histopathological showed an inflammatory lymphoplasmacytic infiltrate, moderate edema of alveoli, vascular congestion and suffusion hemorrhage. Administration of aqueous extract to OVA-sensitized rats caused a significant and very highly significant improvement of MDA levels in lungs, erythrocytes, GSH, GPx, GST, catalase and SOD. We notice a decrease in IL-4 in LBA and lungs alongside reduced inflammatory cell infiltration, mild bronchiolar dilation, mild alveolar edema and normal cell morphology allowing us to conclude on the effectiveness of anti-inflammatory activity of Roman chamomile.

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“…108 Leaves were extracted with 80% aqueous ethanol, and extract had activity against inflammatory cytokines TNF-a and IL-5 in the lungs of mice. 109 In this important report, gel was prepared (procedure is provided) using aqueous roots extract. The gel was used to treat patients with chronic periodontitis and proved strong activity.…”

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confidence: 99%

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

Azab¹

2020

ECB

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Flavonoid-Rich Alcoholic Extract of Leaves of Achyranthes Aspera Reduces Inflammation in a Murine Model of Ova-Induced Asthma

Cited by 3 publications

References 0 publications

Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model

Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

Amaranthaceae plants of Israel and Palestine: Medicinal activities and unique compounds

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