Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults

Abstract

Background: Flavonoids are plant-based phytochemicals with cardiovascular protective properties. Few studies have comprehensively examined flavonoid classes in relation to cardiovascular disease mortality. Objective: We examined the association between flavonoid intake and cardiovascular disease (CVD) mortality among participants in a large, prospective US cohort. Design: In 1999, a total of 38,180 men and 60,289 women in the Cancer Prevention Study II Nutrition Cohort with a mean age of 70 and 69 y, respectively, completed questionnaires on medical history and lifestyle behaviors, including a 152-item food-frequency questionnaire. Cox proportional hazards modeling was used to calculate multivariate-adjusted hazard RRs and 95% CIs for associations between total flavonoids, 7 flavonoid classes, and CVD mortality. Results: During 7 y of follow-up, 1589 CVD deaths in men and 1182 CVD deaths in women occurred. Men and women with total flavonoid intakes in the top (compared with the bottom) quintile had a lower risk of fatal CVD (RR: 0.82; 95% CI: 0.73, 0.92; P-trend = 0.01). Five flavonoid classes-anthocyanidins, flavan-3-ols, flavones, flavonols, and proanthocyanidins-were individually associated with lower risk of fatal CVD (all P-trend , 0.05). In men, total flavonoid intakes were more strongly associated with stroke mortality (RR: 0.63; 95% CI: 0.44, 0.89; P-trend = 0.04) than with ischemic heart disease (RR: 0.90; 95% CI: 0.72, 1.13). Many associations appeared to be nonlinear, with lower risk at intakes above the referent category. Conclusions: Flavonoid consumption was associated with lower risk of death from CVD. Most inverse associations appeared with intermediate intakes, suggesting that even relatively small amounts of flavonoid-rich foods may be beneficial.Am J Clin Nutr 2012;95:454-64.

Chard (Beta Vulgaris Var. Cicla) Extract Modulates Zinc Status, Glucose Level and Antioxydant Values in Diabetic Rats Fed Zinc Deficiency Diet

“…Antioxidant compounds like phenolic acids, polyphenols and flavonoids scavenge free radicals such as peroxide, hydroperoxide of lipid hydroxyl and halt the oxidative mechanism that leads to degenerative diseases [29]. Flavonoids are proactive polyphenolic compounds found in most plants and cannot be synthesized or produced by the humans [30]. They were found to be effective in controlling various biological activities.…”

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

“…Flavonoids exhibit various beneficial properties in a multitude of disease states, including cardiovascular disease, neurodegenerative disorders and cancer (Gao et al, 2012;Master et al, 2012;McCullough et al, 2012). Luteolin, 3',4',5,7-tetrahydroxyflavone, is a common dietary flavonoid can be found in avariety of vegetables, fruits, and medicinal herbs (Sasaki et al, 2003).…”

Modificaciones en el nivel de anión superóxido en leche materna, según la ingesta de flavonoides y carotenoides

“…19 Respecto de la ingesta total de flavonoides, la misma se encontró mayormente en el tercil medio de consumo (42.97-81.26 mg/día), menor a lo informado en la mayoría de otros trabajos (204-527 mg/día). 20,21 No obstante, otro reporte de amplio alcance geográfico encontró valores similares y elevada variabilidad entre los individuos. 22 Los flavonoides más consumidos fueron los flavonoles, flavanonas y flavanoles, seguidos de las flavonas e isoflavonas, en coincidencia con otros estudios.…”