Flavonoid Glycosides and their p-Coumaroyl Esters from Campylospermum calanthum Leaves

The study of the MeOH extract of the leaves of Campylospermum excavatum led to the isolation of a nitrile glucoside, named campyloside C (1) and an original derivative of ochnaflavone, 7-O-methylochnaflavone (2), along with three known biflavonoids, amentoflavone, sequoiaflavone, and sotetsuflavone (3 - 5). The linkage site of the sub-units of 2 was confirmed by chemical correlation, after semi-synthesis of a trimethoxylated derivative of ochnaflavone (2a). The structures of these compounds as well as their relative and absolute configurations were assigned by 1D- and 2D-NMR experiments, HR-ESI-MS and Electronic Circular Dichroism (ECD) calculations. A low-pass J filter HMBC experiment was performed in order to define the configuration of the double bond of 1. All of the biflavonoids were evaluated against protozoan parasites. Amentoflavone moderately inhibited the promastigote form of Leishmania infantum.

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A Nitrile Glucoside and Biflavones from the Leaves of Campylospermum excavatum (Ochnaceae)

Njock

Grougnet

Efstathiou

et al. 2017

Chemistry & Biodiversity

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Rhamnetin Glycosides from the Genus Spiraea

Оленников

Чирикова

2018

Chem Nat Compd

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Flavonoid Glycosides and their p-Coumaroyl Esters from Campylospermum calanthum Leaves

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A Nitrile Glucoside and Biflavones from the Leaves of Campylospermum excavatum (Ochnaceae)

A Nitrile Glucoside and Biflavones from the Leaves of Campylospermum excavatum (Ochnaceae)

Rhamnetin Glycosides from the Genus Spiraea

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