Flavonoid Composition of Fruit Tissues of Citrus Species

Nogata, Yoichi; Sakamoto, Koji; Shiratsuchi, Hiroyuki; Ishii, Toshinao; Yano, Masamichi; Ohta, Hiroyuki

doi:10.1271/bbb.70.178

Cited by 574 publications

(439 citation statements)

References 23 publications

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“…hesperidin, naringin and polymethoxylated fl avonoids, whose distributions diff er in Citrus tissues including albedo, fl avedo, pericarp (peel) and seed (7). Earlier studies have revealed that the phenolic compounds exist in higher amounts in Citrus peel than in other parts of Citrus fruit, such as seeds, leaves or fl owers (8).…”

Section: Olea Europaeamentioning

confidence: 99%

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

Şenol

Ankli²,

Reich³

et al. 2016

Food Technol. Biotechnol.

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SummaryInhibitory activity of thirty-one ethanol extracts obtained from albedo, fl avedo, seed and leaf parts of 17 cultivars of Citrus species from Turkey, the bark and leaves of Olea europaea L. from two locations (Turkey and Cyprus) as well as caff eic acid and hesperidin was tested against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), related to the pathogenesis of Alzheimer's disease, using ELISA microtiter assays at 500 μg/mL. Metal-chelating capacity of the extracts was also determined. BChE inhibitory eff ect of the Citrus sp. extracts was from (7.7±0.7) to (70.3±1.1) %, whereas they did not show any inhibition against AChE. Cholinesterase inhibitory activity of the leaf and bark ethanol extracts of O. europaea was very weak ((10.2±3.1) to (15.0±2.3) %). The extracts had either no or low metal-chelating capacity at 500 μg/mL. HPTLC fi ngerprinting of the extracts, which indicated a similar phytochemical patt ern, was also done using the standards of caff eic acid and hesperidin with weak cholinesterase inhibition. Among the screened extracts, the albedo extract of C. limon 'Interdonato', the fl avedo extracts of 'Kara Limon' and 'Cyprus' cultivars and the seed extract of C. maxima appear to be promising as natural BChE inhibitors.

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Section: Olea Europaeamentioning

confidence: 99%

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

Şenol

Ankli²,

Reich³

et al. 2016

Food Technol. Biotechnol.

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“…For example, C. limetta and C. reticulata represents less than 5% of total citrus production; they are used in traditional medicine because of their antihypertensive effect (Arab and Liebeskind 2010); however, to the best of our knowledge, there is only a single report on the flavonoid content of C. limetta (Nogata et al 2006), where hesperidin is described as the major flavonoid component of the juice. Narirutin, rutin and diosmin are also mentioned as minor components.…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic content and bactericidal effect of Mexican Citrus limetta and Citrus reticulata

et al. 2017

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In this study, total phenolics, total flavonoids, hesperidin and ascorbic acid contents in bagasse, juice and seed of mexican sweet lime (Citrus limetta) and mandarine (Citrus reticulata) were determined at two commercial maturity stages (maturation index), as well as their bactericidal effect on Escherichia coli and Staphylococcus aureus. The results showed that bagasses had the highest total phenolics, total flavonoids, and hesperidin content for both, C. limetta, and C. reticulata; highest ascorbic acid contents were found in C. limetta juice (3.36 ± 0.25 mg g -1 DW) and C. reticulata bagasse (3.83 ± 0.37 mg g -1 DW). All tested extracts showed bacterial growth inhibition at 50 and 800 lg mL -1 . Bagasse extracts of both fruits showed the highest inhibitions ([90%) on tested bacteria. Total phenolics, total flavonoids, and hesperidin contents, as well as bactericidal effect increased with maturity. Results indicated that both Mexican citric fruits (C. limetta and C. reticulata) were good sources of antioxidant and bactericidal agents.

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“…Flavonoids are improtant phytochemicals characterized by a common benzo-γ-pyrone chemical structure and found widely in different plants, especially in genus Citrus (Nogata et al, 2006;Rutaceae et al, 2006;Uehara et al, 2012). Flavonoids exhibit various beneficial properties in a multitude of disease states, including cardiovascular disease, neurodegenerative disorders and cancer (Gao et al, 2012;Master et al, 2012;McCullough et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

Wang¹,

Wang²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Luteolin is a plant flavonoid which exhibits anti-oxidative, anti-inflammatory and anti-tumor effects. However, the antiproliferative potential of luteolin is not fully understood. In this study, we investigated the effect of luteolin on cell cycling and apoptosis in human esophageal squamous carcinoma cell line Eca109 cells. MTT assays showed that luteolin had obvious cytotoxicity on Eca109 with an IC 50 of 70.7±1.72μM at 24h. Luteolin arrested cell cycle progression in the G0/G1 phase and prevented entry into S phase in a dose-and time-dependent manner. as assessed by FCM. Luteolin induced apoptosis of Eca109 cells was demonstrated by AO/EB staining assay and annexin V-FITC/PI staining. Moreover, luteolin downregulated the expression of cyclin D1, survivin and c-myc, and it also upregulated the expression of p53, in line with the fact that luteolin was able to inhibit Eca109 cell proliferation.

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Flavonoid Composition of Fruit Tissues of Citrus Species

Cited by 574 publications

References 23 publications

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

Polyphenolic content and bactericidal effect of Mexican Citrus limetta and Citrus reticulata

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

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