Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers

Nazaruk, Jolanta; Jakoniuk, P

doi:10.1016/j.jep.2005.06.012

Cited by 61 publications

(40 citation statements)

References 7 publications

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“…All. flowers (12,13) and from Erigeron acris L. herb (14) which Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action stimulate collagen biosynthesis with potential for OI type I pharmacological therapy.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action

Gavin¹,

Nazaruk²

2007

Int J Mol Med

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Abstract. The aim of the present study was to identify bioactive compounds stimulating collagen biosynthesis with potential for osteogenesis imperfecta (OI) type I pharmacological therapy. Of the compounds tested, apigenin glycosides 7-O-glucuronide, 7-O-methylglucuronide and pectolinarin at 30 μM were found to significantly induce collagen type I synthesis in OI fibroblasts without an effect on the overall protein synthesis. None of the compounds displayed any toxicity at that concentration. Secretion of collagen into media was not affected by apigenin 7-Oglucuronide and was slightly increased in cells treated with apigenin 7-O-methylglucuronide and pectolinarin. Furthermore, procollagen secreted by treated cells underwent a more rapid processing into collagen as compared with control untreated cells. In addition, we elucidated the possible mechanism involved in their action. Stimulation of collagen biosynthesis was not due to an increase in cell proliferation, because no differences in DNA content between the compound-treated and untreated cells were observed. Since flavonoids are known as strong inhibitors of metalloproteinases degrading matrix proteins, the increased level of collagen could result from the inhibition of their activity. However, the compounds with a stimulatory effect on collagen synthesis did not influence the activities of collagenase type I, gelatinases A and B, and stromelysin. On the contrary, all compounds stimulated the activity of prolidase which catalyzes the final step of collagen degradation and plays an important role in collagen biosynthesis. Stimulation of collagen synthesis and prolidase activity by apigenin 7-Oglucuronide was accompanied by an increase in IGF-I receptor expression. In contrast, the compounds apigenin 7-O-methylglucuronide and pectolinarin which normalized collagen synthesis in OI cells may exert their effects through ß1-integrin-mediated signaling.

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Section: Introductionmentioning

confidence: 99%

Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action

Gavin¹,

Nazaruk²

2007

Int J Mol Med

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“…The lowest concentration of sample at which the subculture from test dilution yielded no viable organisms was recorded as minimum bactericidal concentration (Nazaruk and Jakoniuk, 2005). Decreasing concentration of drug was added to the tubes usually a step wise dilution (2-fold serial dilutions) was used starting from highest to lowest concentrations.…”

Section: Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Synergistic activity of methanolic extract of Thespesia populnea (malvaceae) flowers with oxytetracycline

Kumar

Venkateshwaran

Vanitha³

et al. 2008

Bangladesh J Pharmacol

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“…Cirsium spp. is also bioactive and has antimicrobial, anti-diabetic, anti-oxidant, hepatoprotective, antiinflammatory, vasorelaxant, and anti-cancer properties (Perez et al 2001;Park et al 2004;Nazaruk and Jakoniuk 2005;Liu et al 2007;Jeong et al 2008;Kim et al 2008;Ku et al 2008;Lim et al 2008;Yoo et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Determination of pectolinarin inCirsiumspp. using HPLC/UV analysis

Cho

Lee

et al. 2016

JABC

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Pectolinarin was isolated from the ethyl acetate fraction of Cirsium setidens using open column chromatography and was analyzed using spectrometry. Pectolinarin content in Cirsium spp. was determined using HPLC/UV. Pectolinarin content in the aerial part of Cirsium spp. was higher than that in the root and pappus. Pectolinarin content was highest in the aerial part of C. chlorolepis (110.65 mg/g extract). Consequently, the aerial part of C. chlorolepis has potential for use in new natural medicinal products, health supplements, and beverages.

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Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers

Cited by 61 publications

References 7 publications

Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action

Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action

Synergistic activity of methanolic extract of Thespesia populnea (malvaceae) flowers with oxytetracycline

Determination of pectolinarin inCirsiumspp. using HPLC/UV analysis

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