Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros, Raúl; Sacerdote, Carlotta; Ricceri, Fulvio; Weiderpass, Elisabete; Roswall, Nina; Buckland, Genevieve; St-Jules, David E.; Overvad, Kim; Kyrø, Cecilie; Fagherazzi, Guy; Kvaskoff, Marina; Severi, Gianluca; Chang‐Claude, Jenny; Kaaks, Rudolf; Nöthlings, Ute; Trichopoulou, Antonia; Naska, Androniki; Trichopoulos, Dimitrios; Palli, Domenico; Grioni, Sara; Mattiello, Amalia; Tumino, Rosario; Gram, Inger Torhild; Engeset, Dagrun; Huerta, José María; Molina‐Montes, Esther; Argüelles, Marcial; Amiano, Pilar; Ardanáz, Eva; Ericson, Ulrica; Lindkvist, Björn; Nilsson, Lena; Kiemeney, Lambertus A.; Ros, Martine M.; Bueno-de-Mesquita, H. B.; Peeters, Petra H.M.; Khaw, Kay‐Tee; Wareham, Nick; Knaze, Viktoria; Romieu, Isabelle; Scalbert, Augustin; Brennan, Paul; Wark, Petra A.; Víneis, Paolo; Riboli, Elio; González, Carlos

doi:10.1038/bjc.2014.459

Cited by 54 publications

(52 citation statements)

References 42 publications

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“…Several of these items are not consumed frequently in the Australian population. Others food items are more frequently consumed and therefore might have influenced the DII computed in our study; this may be especially true for flavonoids which are frequently consumed and have recently been associated with the risk of UCC . Although we could not test and confirm this result in our cohort, other studies have observed relatively strong correlations between inflammatory biomarkers and the DII when it was computed with fewer than 30 food parameters .…”

Section: Discussionmentioning

confidence: 62%

Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study

Dugué

Hodge

Brinkman

et al. 2016

Intl Journal of Cancer

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Studies investigating the association of food and nutrient consumption with the risk of urothelial cell carcinoma (UCC) have produced mixed results. We used three common dietary scores, the Mediterranean Diet Score (MDS), the Alternate Healthy Eating Index 2010 (AHEI-2010), and the Dietary Inflammatory Index (DII) to assess the evidence of an association between diet and the risk of UCC. Over a median follow-up time of 21.3 years, 379 incident UCC cases were diagnosed. Dietary scores were calculated using data from a 121-item food frequency questionnaire administered at baseline. We used Cox models to compute hazard ratios (HR) for the association between dietary scores (per one standard deviation) and UCC risk. In order to reflect overall adherence to a healthy diet, a metascore was constructed by summing the quintiles of each of the three scores. None of the dietary scores was associated with the risk of UCC overall. A healthier diet was found to be inversely associated with the risk of invasive (MDS: HR=0.86, 95% CI: 0.74–1.00, metascore: HR=0.84, 95% CI: 0.71–0.98), but not superficial disease (heterogeneity between subtypes p=0.04 and p=0.03, respectively). Results were consistent but weaker for DII and AHEI-2010. We found some evidence of effect modification by smoking, in particular for the metascore (Current: HR=0.77, 95% CI: 0.58–1.01, Former: HR=0.77, 95% CI: 0.64–0.92, Never: HR=1.01, 95% CI: 0.81–1.26, p for heterogeneity=0.05). A healthy diet may be protective against the risk of invasive, but not superficial, UCC. Promoting healthy dietary habits may help lower the risk of invasive UCC, especially for current and former smokers.

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Section: Discussionmentioning

confidence: 62%

Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study

Dugué

Hodge

Brinkman

et al. 2016

Intl Journal of Cancer

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“…It is well known that after oral ingestion, polyphenols are excreted in urine and may reach concentrations high enough to exert a biological effect (29,30). This phenomenon may explain the reduced incidence of BCa evidenced by epidemiological studies (3,6). …”

Section: Discussionmentioning

confidence: 93%

“…Ros et al showed that a higher plasma carotenoid concentration was associated with a lower incidence of BCa, suggesting that specific compounds in fruit and vegetables may exert protective effects on BCa risk (5). Moreover, data of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, found an inverse association between the dietary intake of flavanols and lignans and the risk of BCa (6). …”

Section: Introductionmentioning

confidence: 99%

Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells

et al. 2016

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Epidemiological data indicate that the daily consumption of extra-virgin olive oil (EVOO), a common dietary habit of the Mediterranean area, lowers the incidence of certain types of cancer, in particular bladder neoplasm. The aim of the present study was to evaluate the antiproliferative activity of polyphenols extracted from EVOO on bladder cancer (BCa), and to clarify the biological mechanisms that trigger cell death. Furthermore, we also evaluated the ability of low doses of extra-virgin olive oil extract (EVOOE) to modulate the in vitro activity of paclitaxel or mitomycin, two antineoplastic drugs used in the management of different types of cancer. Our results showed that EVOOE significantly inhibited the proliferation and clonogenic ability of T24 and 5637 BCa cells in a dose-dependent manner. Furthermore, cell cycle analysis after EVOOE treatment showed a marked growth arrest prior to mitosis in the G2/M phase for both cell lines, with the subsequent induction of apoptosis only in the T24 cells. Notably, simultaneous treatment of mitomycin C and EVOOE reduced the drug cytotoxicity due to inhibition of ROS production. Conversely, the co-treatment of T24 cells with paclitaxel and the polyphenol extract strongly increased the apoptotic cell death at each tested concentration compared to paclitaxel alone. Our results support the epidemiological evidence indicating that olive oil consumption exerts health benefits and may represent a starting point for the development of new anticancer strategies.

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“…The European Prospective Investigation into Cancer and Nutrition (EPIC) study has had a particularly large population with wide ranges of intake for different dietary constituents. The data suggested an inverse association between dietary intake of flavonols and the risk of bladder cancer [Zamora‐Ros et al, ].…”

Section: Flavonols and Cancer Preventionmentioning

confidence: 99%

Flavonol Regulation in Tumor Cells

Lea¹

2015

J of Cellular Biochemistry

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Flavonols comprise a group of flavonoid molecules that are widely distributes in fruits and vegetables. There is epidemiological data to suggest that consumption of flavonols can be accompanied by decreased cancer incidence. The anti-oxidant activity of flavonols may have an important role in preventing carcinogenesis. Therapeutic potential of flavonols is indicated by their growth inhibitory action accompanied by a decrease in several hallmarks of cancer such as resistance to apoptosis. Multiple mechanisms of action have been reported for the action of flavonols on cancer cells. Particular emphasis has been directed to inhibitory effects on several protein kinases and on the potential for prooxidant effects. The diversity of actions presents a problem in trying to elucidate primary and secondary effects but it may be a strength of the therapeutic potential of flavonols that it renders development of resistance more difficult for cancer cells. Cancer chemotherapy is usually characterized by the use of drug combinations. Some additive or synergistic combinations have been identified for flavonols and this is an area of ongoing investigation. As with other polyphenolic molecules there have been questions of cellular uptake and bioavailability. Several investigations have been and are being conducted to modify the structures of flavonols with the goal of increasing bioavailability. At present many investigators are sufficiently encouraged by past observations that they are responding to the challenge to optimize the dietary and therapeutic use of flavonols in cancer prevention and treatment.

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Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Cited by 54 publications

References 42 publications

Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study

Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study

Extra-virgin olive oil phenols block cell cycle progression and modulate chemotherapeutic toxicity in bladder cancer cells

Flavonol Regulation in Tumor Cells

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