Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity

Hostetler, Gregory L.; Ralston, Robin A.; Schwartz, Steven J.

doi:10.3945/an.116.012948

Cited by 444 publications

(295 citation statements)

References 141 publications

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“…Additionally, MMS is known to facilitate the formation of adducts such as N7 -methylguanine ( N7 MeG), N3 -methylguanine ( N3 MeG), and N3 -methyladenine ( N3 MeA), as well as crosslinks expressed as base substitution mutations. Although DNA adducts do not directly block replication, they produce apurinic sites, with consequent breaks in the double strands [23] that are repaired by base excision, the main defense mechanism against SN2 agents [24]. Regarding the mechanism of action underlying MMS-induced genotoxicity, VdE may act as a chemoprotector by competing with DNA as a target for alkylation, reducing MMS-induced genotoxic damage.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil)

Oliveira

Mendes

Acésio

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The medicinal plant Vochysia divergens is a colonizing tree species of the Pantanal, a unique and little explored wetland region in Brazil. This species is used in folk medicine as syrups and teas to treat respiratory infections, digestive disorders, asthma, scarring, and skin diseases. The objectives of this study were to evaluate the antioxidant, cytotoxic, and genotoxic potential of the ethanolic extract of Vochysia divergens leaves (VdE), as well as the influence of VdE and its major component (the flavone 3′,5-dimethoxy luteolin-7-O-β-glucopyranoside; 3′5 DL) on MMS-induced genotoxicity. The extract significantly reduced the viability of V79 cells in the colorimetric XTT assay at concentrations ≥ 39 μg/mL. A significant increase in micronucleus frequencies was observed in V79 cell cultures treated with VdE concentrations of 160 and 320 μg/mL. However, animals treated with the tested doses of VdE (500, 1000, and 2000 mg/kg b.w.) exhibited frequencies that did not differ significantly from those of the negative control group, indicating the absence of genotoxicity. The results also showed that VdE was effective in reducing MMS-induced genotoxicity at concentrations of 20, 40, and 80 μg/mL in the in vitro test system and at a dose of 15 mg/kg b.w. in the in vivo test system. Its major component 3′5 DL exerted no protective effect, suggesting that it is not responsible for the effect of the extract. The results of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay showed that VdE was able to scavenge 92.6% of free radicals. In conclusion, the results suggest that the protective effect of VdE may be related, at least in part, to the antioxidant activity of its chemical constituents.

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Section: Discussionmentioning

confidence: 99%

Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil)

Oliveira

Mendes

Acésio

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…They are mainly present in their glycoside forms. Recently, Hostetler, Ralston, and Schwartz () summarized, on the basis of existing studies, the concentration of flavones in teas and dry herbs, in juices and wines, in fruits, vegetables, olive oil, and honey. As instance, for wheat grain apigenin‐c‐glycosides, a value of 2.1‐mg/100‐g dry weight has been observed (Wijaya & Mares, ) and for black olives values of 6.5 and in the range 3.2–17.5‐mg/100‐g fresh weight for apigenin and luteolin, respectively (Bhagwat et al, ; Owen et al, ).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Durazzo

Lucarini

Souto

et al. 2019

Phytotherapy Research

544

397

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This review gives an updated picture of each class of phenolic compounds and their properties. The most common classification implies the subdivision of phenolics in two main groups: flavonoids (e.g., anthocyanins, flavanols, flavanones, flavonols, flavonones, and isoflavones) and non‐flavonoids (e.g., phenolic acids, xanthones, stilbens, lignans, and tannins) polyphenols. The great interest in polyphenols is associated with their high potential application for food preservation and for therapeutic beneficial use. The relationship between polyphenol intake and human health has been exploited with special reference to cardiovascular diseases, hypertension, diabetes, metabolic syndrome, obesity, and cancer. The use of current existing databases of bioactive compounds including polyphenols is described as key tools for human health research.

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“…The structure backbone of flavones subclass is shown in Figure . Hostetler, Ralston, and Schwartz () recently reviewed the studies on food source, bioavailability, and potential benefits of flavones. Moreover, the authors reported the researches present in the literature on flavones in juices (citron juice, orange juice, and kumquat juices).…”

Section: Antioxidant Properties Of Fruit‐based Juice: An Overviewmentioning

confidence: 99%

Fruit‐based juices: Focus on antioxidant properties—Study approach and update

Durazzo

Lucarini

Novellino

et al. 2019

Phytotherapy Research

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This paper proposes a perspective literature review of the antioxidant properties in fruit‐based juices. The total antioxidant properties due to compounds such as carotenoids, polyphenolic compounds, flavonoids, and tannins as well as the assessment of interactions between natural active compounds and other food matrix components can be seen as the first step in the study of potential health benefits of fruit‐based juices. A brief summary is given on the significance of antioxidant properties of fruit juices, the conventional methods for antioxidant activity evaluation, and on the newly emerged sample analysis and data interpretation strategies, that is, chemometric analysis based on spectroscopic data. The effect of fruit processing techniques and the addition of ingredients on the antioxidant properties of fruit‐based juices are also discussed.

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Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity

Cited by 444 publications

References 141 publications

Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil)

Genotoxic and Chemopreventive Effects of Vochysia divergens Leaves (Pantanal, Brazil)

Polyphenols: A concise overview on the chemistry, occurrence, and human health

Fruit‐based juices: Focus on antioxidant properties—Study approach and update

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