Flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2 mediated downregulation of STAT3/Hif-1α/VEGF signalling pathway
Abstract:This study investigates the effects of Flavokawain B (FKB) on the growth and development of metastatic hepatocellular carcinoma. HepG2 cells were used in this study and a neutral red assay was performed to determine the anti-proliferation effects of FKB at varying concentrations. Cell scratch and exclusion zone assays were performed to assess the inhibitory effects of FKB on the cell migration and invasion and relative mRNA levels were quantified using the RT-qPCR. FKB inhibited the proliferation of HepG2 cell… Show more
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