Abstract:Background and Purpose Hepatocellular carcinoma has high ability of
vascular invasion and metastasis. Vasculogenic mimicry (VM) is closely
related to the metastasis and recurrence of hepatocellular carcinoma
(HCC). According to previous research, Chloranthus henryi has anti-tumor
effect, but its molecular mechanism in the treatment of HCC has not yet
been stated. In our study, we aimed to investigate the effect of the
extract of Chloranthus henryi in HCC and its target and molecular
mechanism. Experimental App… Show more
“…It is now well established that tumor vasculogenesis is not exclusively attributable to endothelial cells. The tumor cells themselves mimic endothelial function by acquiring plasticity, forming vasculogenic-like networks that provide blood supply for tumor growth and metastasis [5][6][7] . This endothelial cell-independent microcirculation pattern is named vascular mimicry (VM).…”
“…It is now well established that tumor vasculogenesis is not exclusively attributable to endothelial cells. The tumor cells themselves mimic endothelial function by acquiring plasticity, forming vasculogenic-like networks that provide blood supply for tumor growth and metastasis [5][6][7] . This endothelial cell-independent microcirculation pattern is named vascular mimicry (VM).…”
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