Flavivirus Infection and Regulation of Host Immune and Tissue Homeostasis in Insects

Harsh, Sneh; Eleftherianos, Ioannis

doi:10.3389/fimmu.2020.618801

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…In insect-flavivirus interactions, Dicer proteins appear to be equally important ( Angleró-Rodríguez et al., 2017 ; Mukherjee et al., 2019 ; Harsh and Eleftherianos, 2020 ; Qiu et al., 2020 ). For instance, the inhibition of Dicer-2 results in the reduction of the Vago protein, which is an important player in the control of the infection by WNV ( Paradkar et al., 2014 ).…”

Section: Micrornasmentioning

confidence: 99%

Interactions of host miRNAs in the flavivirus 3´UTR genome: From bioinformatics predictions to practical approaches

Avila-Bonilla

Salas-Benito

2022

Front. Cell. Infect. Microbiol.

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The genus Flavivirus of the Flaviviridae family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic cells synthesize small RNA molecules that can bind specifically to sequences present in messenger RNAs to inhibit the translation process, thus regulating gene expression. These small RNAs have been named microRNAs, and they have an important impact on viral infections. In this review, we compiled the available information on miRNAs that can interact with the 3’ untranslated region (3’UTR) of the flavivirus genome, a conserved region that is important for viral replication and translation.

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Section: Micrornasmentioning

confidence: 99%

Interactions of host miRNAs in the flavivirus 3´UTR genome: From bioinformatics predictions to practical approaches

Avila-Bonilla

Salas-Benito

2022

Front. Cell. Infect. Microbiol.

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WSV056-mediated downregulation of PvSMCT1 contributes to immune evasion of white spot syndrome virus in the infection of Penaeus vannamei

Wang

Chen

et al. 2023

Aquaculture

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Immune Reactions of Vector Insects to Parasites and Pathogens

Ratcliffe,

Mello,

Castro

et al. 2024

Microorganisms

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This overview initially describes insect immune reactions and then brings together present knowledge of the interactions of vector insects with their invading parasites and pathogens. It is a way of introducing this Special Issue with subsequent papers presenting the latest details of these interactions in each particular group of vectors. Hopefully, this paper will fill a void in the literature since brief descriptions of vector immunity have now been brought together in one publication and could form a starting point for those interested and new to this important area. Descriptions are given on the immune reactions of mosquitoes, blackflies, sandflies, tsetse flies, lice, fleas and triatomine bugs. Cellular and humoral defences are described separately but emphasis is made on the co-operation of these processes in the completed immune response. The paper also emphasises the need for great care in extracting haemocytes for subsequent study as appreciation of their fragile nature is often overlooked with the non-sterile media, smearing techniques and excessive centrifugation sometimes used. The potential vital role of eicosanoids in the instigation of many of the immune reactions described is also discussed. Finally, the priming of the immune system, mainly in mosquitoes, is considered and one possible mechanism is presented.

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Flavivirus Infection and Regulation of Host Immune and Tissue Homeostasis in Insects

Cited by 3 publications

References 51 publications

Interactions of host miRNAs in the flavivirus 3´UTR genome: From bioinformatics predictions to practical approaches

Interactions of host miRNAs in the flavivirus 3´UTR genome: From bioinformatics predictions to practical approaches

WSV056-mediated downregulation of PvSMCT1 contributes to immune evasion of white spot syndrome virus in the infection of Penaeus vannamei

Immune Reactions of Vector Insects to Parasites and Pathogens

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