Flavin adenine dinucleotide functionalized gold nanoparticles for the electrochemical detection of dopamine

Medrades, Jennifer de Pontes; Maciel, Cristiane C.; Moraes, Ariana de Souza; Leite, Fábio L.; Ferreira, Marystela

doi:10.1016/j.snr.2022.100085

Cited by 3 publications

(4 citation statements)

References 40 publications

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“…Nonetheless, with diligent training and a meticulous approach, FSCV evolves into a potent instrument for scrutinizing neurotransmitter dynamics in states both normative and pathological. Notably, the advent of advanced tools has demonstrated FSCV’s aptitude for detecting neurotransmitters at low concentrations [ 24 , 25 , 26 , 27 , 28 ]. Moreover, FSCV exhibits compatibility with other techniques, exemplified by its synergy with Raman Spectroscopy, culminating in a hybrid sensing platform that merges spectral and electrochemical data of the sample [ 29 , 30 ].…”

Section: In Vivo Neurotransmitter Sensing Techniquesmentioning

confidence: 99%

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Lachance,

Gauvreau,

Boisselier

et al. 2024

Sensors

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Neurotransmitter analysis plays a pivotal role in diagnosing and managing neurodegenerative diseases, often characterized by disturbances in neurotransmitter systems. However, prevailing methods for quantifying neurotransmitters involve invasive procedures or require bulky imaging equipment, therefore restricting accessibility and posing potential risks to patients. The innovation of compact, in vivo instruments for neurotransmission analysis holds the potential to reshape disease management. This innovation can facilitate non-invasive and uninterrupted monitoring of neurotransmitter levels and their activity. Recent strides in microfabrication have led to the emergence of diminutive instruments that also find applicability in in vitro investigations. By harnessing the synergistic potential of microfluidics, micro-optics, and microelectronics, this nascent realm of research holds substantial promise. This review offers an overarching view of the current neurotransmitter sensing techniques, the advances towards in vitro microsensors tailored for monitoring neurotransmission, and the state-of-the-art fabrication techniques that can be used to fabricate those microsensors.

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Section: In Vivo Neurotransmitter Sensing Techniquesmentioning

confidence: 99%

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Lachance,

Gauvreau,

Boisselier

et al. 2024

Sensors

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“…The functionalization of MNPs is an emerging methodology that improves selectivity and inherits the task-specific properties from MNPs. Flavin adenine dinucleotide (FAD) functionalized GNPs were synthesized and utilized as sensing probes for the selective sensing of DA at nanomolar levels (LOD, 525 nM) [ 79 ]. Briefly, a gold substrate was self-assembled with a monolayer of mercaptoundecanoic acid (MDA), then covered with a layer of cationic poly(ethyleneimine), and finally, the negatively charged FAD-GNPs were immobilized via electrostatic interaction in order to obtain the desired biosensor.…”

Section: Various Nanomaterial-modified Electrodesmentioning

confidence: 99%

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Theyagarajan

Kim

2023

Biosensors

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Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces.

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“…MNPs usually come combined with other nanomaterials as Pc [157][158][159]163,168], carbon-based materials [145,165,169,170], clays [171,172], ionic liquids [168,173], among others. In addition, MNPs have been combined with biomolecules for biosensing applications [169,[174][175][176][177]. To contextualize, Salvo-Comino et al [178] have combined materials with complimentary functionalities by the LbL technique to build an enzymatic sensor for catechol: Pc as an efficient electron mediator, the ionic liquid to improve the conductivity of the film, and chitosan to create a suitable environment to the enzyme.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

“…AuNPs are the most used mainly due to their chemical stability and facile surface functionalization. Stable suspensions for the LbL assembly are usually achieved under reduction by polyelectrolyte stabilization [145,165,[179][180][181], ionic liquids [173], glutathione [175,177], and citrate [89,182]. These stable suspensions can be applied as a component of the LbL assembly combined with opposite-charged polyelectrolytes, nanomaterials, or ions.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Exploring Deposition Techniques and Supramolecular Arrangement in Thin Films for Sensor Applications

Miyazaki,

Martin,

Ozório

et al. 2023

Chemosensors

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In recent decades, many research efforts have been dedicated to finding highly sensitive devices for fast and reliable identification and quantification of an expanding range of analytes. As a result, there has been an increased number of publications dedicated to this area and a consequent increase in the number of review papers on the subject. However, unlike most review articles, we chose to explore the impact of supramolecular arrangement (or deeper, when possible, approaching the molecular organization) and assembly variables on sensing performance. This review briefly discusses the methods used to determine the molecular organization of thin films. We also examine various deposition techniques, including Langmuir-Blodgett, Langmuir-Schaefer, Layer-by-Layer assembly, electrodeposition, and spray pyrolysis, describing mainly (but not limited to) the advances in the last five years in developing thin films for sensors, with a particular emphasis on how the supramolecular arrangement can influence the sensing properties of these films.

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Flavin adenine dinucleotide functionalized gold nanoparticles for the electrochemical detection of dopamine

Cited by 3 publications

References 40 publications

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules

Exploring Deposition Techniques and Supramolecular Arrangement in Thin Films for Sensor Applications

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