Flavanones in Citrus fruit: Structure–antioxidant activity relationships

Majo, Danila Di; Giammanco, Marco; Guardia, Maurizio La; Tripoli, E; Giammanco, S; Finotti, Enrico

doi:10.1016/j.foodres.2005.05.001

Cited by 236 publications

(140 citation statements)

References 16 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…In fact, several previous works described the importance of the biological functions of these molecules such as antioxidant 24,[30][31][32] , anti-inflammatory 33,34 , anti-atherosclerotic 35,36 , anticancer 35,37,38 and antimicrobial activities 39,40. Indeed, the ethanol-ethyl acetate (2/1) extract contains 28 mg GAE/g DW of phenolic compounds and 7 mg EQ/g DW of flavonoid contents and show an impor-1 tant antioxidant activity measured on DPPH with an IC50 of 42 µg/mL. These results are in agreement with those obtained by 41 and 24 who reported that there is a close relationship between phenolic and flavonoid content and the antioxidant activity in Eriobotrya japonica extracts.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Kammoun¹,

Yassine²,

Bezzine³

2015

Afr H. Sci.

View full text Add to dashboard Cite

Background: In the present work we determined phenolic and flavonoids content of Eriobotrya japonica leaves extracts and fractions and their antioxidant and anti-inflammatory properties. Objectives: To evaluate the inhibition of inflammatory PLA2 and antioxidant effects of extracts and fractions from Eriobotrya japonica leaves Methods: Antioxidant activity was evaluated with DPPH radical scavenging assay and anti-inflammatory effect of fractions was measured by their inhibition potency on the human pro-inflammatory phospholipase A2 (group IIA). Results: The EtOH/EtOAc 2:1 extract exhibited a potent inhibition of the hG-IIA with an IC50 values of 8 µg/ml. It also shows an antioxidant activity measured on DPPH with an IC50 of 42 µg/ml. Fractionation shows that CH2Cl2/MeOH 0:1 fraction was the rich one on flavonoids compounds (4.3 mg/g dry weight) and demonstrates a high antioxidant activity with an IC50 of 12 µg/ml. The anti-inflammatory evaluation demonstrates that the same fraction was the best one to inhibit the pro-inflammatory phospholipase A2 group IIA with an IC50 of 4 µg/ml. Conclusion: Study conducted on Eriobotrya japonica shows that CH2Cl2/MeOH 0:1 fraction inhibits efficiently the hG-IIA phospholipase.which is considered as pro-inflammatory enzyme.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antioxidant properties of Eriobotrya japonica leaves extracts

Kammoun¹,

Yassine²,

Bezzine³

2015

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

“…However, at both concentrations, the results from the ABTS assay did not significantly differ among all the fractions. Different values are obtained for different assays because each method has multiple reaction characteristics and mechanisms [19]. Therefore, to obtain a more accurate picture of anti-oxidative activity, it is preferable to evaluate activity in multiple assays.…”

Section: Resultsmentioning

confidence: 99%

The comparative study among different fractions of muscadine grape ‘Noble’ pomace extracts regarding anti-oxidative activities, cell cycle arrest and apoptosis in breast cancer

Luo

Song

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

As a by-product of wine making, pomace contains rich amounts of phenolic compounds that can be potentially utilized as raw materials to make beneficial products especially for the anti-cancer agents including the breast cancer. Muscadinia rotundifolia ‘Noble’ is a wine-making grape cultivar, and to better use ‘Noble’ pomace, the most effective phenolic fractions in cancer inhibition must be identified. In this study, anti-oxidative activities of three separated fractions of ‘Noble’ pomace (F1, F2 and F3) were compared in 2,2-diphenyl-1-picrylhydrazyl and 2,2ʹ-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging (DPPH and ABTS) assays as well as the ferric-reducing antioxidant power (FRAP) assay. The ability of different fractions to induce cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells was also evaluated by flow cytometry and Western blot analysis. Fraction F3, which contained a mixture of anthocyanidins and ellagic acids, exhibited the strongest anti-oxidative activity, as determined at both low and high concentrations in the DPPH and FRAP assays. F3 also demonstrated the greatest ability to induce apoptosis via caspase activation and cell cycle arrest by downregulating cyclin A and upregulating p21. F3 was thus the most effective bioactive fraction among those prepared from muscadine grape ‘Noble’ pomace.

show abstract

“…The orange peel is mainly composed of cellulose, pectin and lignin. The effective ingredients can be used as a flavouring agent of food, candy, beverage, and it is also an important raw material of cosmetics and medicine [3][4][5]. At present, bioactive ingredients in orange peel have been developed at China and abroad.…”

Section: Introductionmentioning

confidence: 99%