Flavanoids from Caesalpinia pulcherrima

Srinivas, K.; Rao, Yerra Koteswara; Mahender, I.; Das, Biswanath; Krishna, K. Vamshi; Kishore, K. Hara; Murty, U. S. N.

doi:10.1016/s0031-9422(03)00325-x

Cited by 106 publications

(69 citation statements)

References 11 publications

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“…This seems to provide a rationale for the use of this plant in pain and inflammation. [30] Phytochemical screening showed the presence of flavonoids, [31] steroids, [32] and terpenoids [33,34] which were reported to possess smooth muscle relaxant, bronchodilator, and spasmolytic properties. Flavonoids possess potential pharmacological activities such as antiallergic, antiinflammatory, and antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

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Mamillapalli¹

2017

AJP

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Aim: This investigation has been conducted to evaluate the antiasthmatic activity and phytochemical characterization using gas chromatography-mass spectrum (GC-MS) analysis of the leaf extracts of Talinum portulacifolium. Materials and Methods: Hydroalcoholic and acetone extracts of the plant were prepared. Preliminary phytochemical screening has been conducted. Antiasthmatic activity was determined by two experimental models. In vivo methods, histamine and acetylcholine (Ach)-induced bronchospasm in guinea pigs were studied. Pre convulsion time (PCT) was calculated. In vitro, experimental methods such as histamine and Ach-induced contractions in ileum were also studied. Percentage inhibition of contractions was calculated. Phytochemical characterization was studied using GC-MS analysis. Results and Discussion: In histamine and Ach-induced bronchospasm studies acetone extracts of the plant have significantly increased PCT 10.69 and 10.52 (**P < 0.01), one-way analysis of variance (ANOVA) Tukey's test compared with control. Histamine and Ach-induced ileum contraction studies also showed that the acetone extracts exhibited response 2.6 with 47% and 2.2 with 40% inhibition (*P < 0.05). The results were expressed by one-way ANOVA, Dunnett's test. The results of GC-MS analysis depicted following phytoconstituents with major peak area, namely, 79.29% methoxy-bis (cyclopentadiene), 2. 83% -5,10-dihexyl-5,10-dihydroindolo[3,2-b]indole-2,7-dicarbaldehyde, and 1.84% -1,2-bis[3,4-dimethoxy benzyl]-1,2-bis (methoxymethyl) ethane. Conclusion: The results of this study clearly indicate that the hydroalcoholic and acetone extracts of T. portulacifolium can be used as promising antiasthmatic agents. The activity may be due to the presence of phytochemicals reported through GC-MS.

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Section: Discussionmentioning

confidence: 99%

Untitled

Mamillapalli¹

2017

AJP

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“…The hydroxyl group has been placed at C-7 and the methoxyl group at C-8, C-4Ј on the basis of 1 H-NMR spectrum along with mass spectrum which showed characteristic signals at m/z 146 and 166 due to retroDiels-Alder cleavage of the molecule. The compound 2 was thus characterized as cis (Z)-7-hydroxy-8-methoxy-3-(4-methoxybenzyl) chroman-4-one which is the cis (Z) isomer of 8-methoxybonducellin, the structure was further confirmed from its 13 C-NMR (see Table 2) and HMBC experimental data. Thus the compound 2 was unambiguously established and named 8-methoxyisobonducellin.…”

mentioning

confidence: 83%

“…The molecular formula was established as C 18 12) The position of the vinylic proton was indicative of a cis (Z) double bond at C 3 -C 9 as the corresponding signal for cis (Z)-isomer appears at (d 6.97) and (d 4.99). 13) And the signal for H-2 at d 5.05 (2H) showed a cross-peak with the signal of H-9 at d 7.02 (1H) in the NOESY spectrum. The 1 H-NMR spectrums also revealed the presence of a hydroxyl (d 10.34), two methoxyl groups (d 3.78, 3.70) in the molecule.…”

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confidence: 86%

“…Hand 13 C-NMR spectra of compound 1 (Table 1; all assignments based on HMQC, HMBC experiments) showed the presence of a tamarixetin core, a trans-caffeoyl moiety, and a galactopyranosyl unit. The Hz, H-5Ј), 7.50 (1H, d, Jϭ 2.0 Hz, H-2Ј), and 7.65 (1H, dd, Jϭ8.5, 2.0 Hz, H-6Ј), correlated with the carbons at 115.88, 116.57 and 122.65 ppm respectively in the HMQC spectrum, characterized the ABX system due to 3Ј,4Ј-disubstituted B-ring.…”

mentioning

confidence: 99%

“…4 The 3-benzylidenechroman-4-one system was established from analyses of their 1 H-NMR spectra and the E-geometry of the D 3,9 was clearly discerned by the characteristic chemical shifts of the C-9 proton at d 7.6 and C-2 proton at d 5.3 ppm. 11,13) They were characterized as the known compounds: eucomin (3), 11) bonducellin (4), 13) 8-methoxybonducellin (5), 12) and intricatinol (6), 14) respectively from their spectral (UV, IR, 1D and 2D NMR and MS) data and by comparison of the values with those reported earlier for the compounds.…”

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confidence: 99%

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