Flattened cortisol rhythms in metastatic breast cancer patients

Abercrombie, Heather C.; Giese‐Davis, Janine; Sephton, Sandra E.; Epel, Elissa S.; Turner‐Cobb, Julie M.; Spiegel, David

doi:10.1016/j.psyneuen.2003.11.003

Cited by 260 publications

(199 citation statements)

References 55 publications

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“…In keeping with our predictions, and in line with previous research (Adam & Gunnar, 2001;Abercrombie et al, 2004), Figure 2. Women's afternoon cortisol and marital satisfaction predicting evening cortisol.…”

Section: Cortisol Cycle and Marital Satisfactionsupporting

confidence: 93%

Marital satisfaction, recovery from work, and diurnal cortisol among men and women.

Saxbe¹,

Repetti²,

Nishina³

2008

Health Psychology

142

123

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Design: Multilevel modeling was used to model relationships between salivary cortisol, daily diary ratings of work experiences, and Marital Adjustment Test scores (Locke & Wallace, 1959), in a sample of 60 adults who sampled saliva 4 times per day over 3 days. Results: Among women but not men, marital satisfaction was significantly associated with a stronger basal cortisol cycle, with higher morning values and a steeper decline across the day. For women but not men, marital satisfaction moderated the within-subjects association between afternoon and evening cortisol level, such that marital quality appeared to bolster women's physiological recovery from work. For both men and women, evening cortisol was lower than usual on higher-workload days, and marital satisfaction augmented this association among women. Men showed higher evening cortisol after more distressing social experiences at work, an association that was strongest among men with higher marital satisfaction. Conclusion: This work has implications for the study of physiological recovery from work, and also suggests a pathway by which marital satisfaction influences allostatic load and physical health.

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Section: Cortisol Cycle and Marital Satisfactionsupporting

confidence: 93%

Marital satisfaction, recovery from work, and diurnal cortisol among men and women.

Saxbe¹,

Repetti²,

Nishina³

2008

Health Psychology

142

123

View full text Add to dashboard Cite

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“…This is not in keeping with some of the other published literature in this field which has shown, for example, the presence of flatter diurnal rhythms and higher mean cortisol levels in women with breast cancer, compared with controls (e.g. Abercrombie et al, 2004). The differences between these investigations may reflect differences in the disease stage of the patients and/or in their treatment modalities.…”

Section: Discussioncontrasting

confidence: 75%

Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls

Vedhara

Tuinstra

Miles

et al. 2006

Psychoneuroendocrinology

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Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls Vedhara, K.; Tuinstra, Jolanda; Miles, J.N.V.; Sanderman, Robbert; Ranchor, Adelita V. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. SummaryThe present study was designed to (i) explore which psychosocial factors were associated with indices representing the early morning peak, diurnal cortisol rhythm and area under the curve (AUC); (ii) examine whether the relationships between psychosocial functioning and these cortisol indices were consistent and (iii) explore whether these relationships were influenced by the clinical status of the participant. Newly diagnosed breast cancer patients (nZ85) and healthy control women (nZ59) were recruited. State and trait measures of psychosocial functioning (i.e. anxiety, depression, distress, neuroticism, extraversion, marital satisfaction and mastery) were undertaken. In addition, all participants provided four saliva samples (on waking, 30 min later, between 11 and 1 p.m., before lunch and between 8 and 10 p.m., at least 2 h after evening meal) over two consecutive days to assess cortisol levels. The results highlighted the divergent nature of the four cortisol indices; revealed the presence of some significant relationships between the psychosocial measures and the cortisol indices; but highlighted inconsistencies in the relationships evident for patients and those observed for control women. Q

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“…(Conti et al 2004;Terreni & De Simoni, 1998) and IL-6 has been linked to depressive spectrum behaviors characterized as "sickness behaviors" (Dantzer et al, 2002;Dantzer, 2006). Both IL-6 and hypercortisolemia have been linked to depression (Dowlati et al, 2010;Howren et al 2009;Liu et al 2011;Lopez-Duran et al 2009;Stetler & Miller, 2011) and disruption of cortisol rhythms has been linked to depression in breast and ovarian cancer populations (Abercrombie et al 2004;Jehn et al 2006);Lutgendorf et al 2008;Weinrib et al 2010) It is possible that the residual tumor mass may have affected both inflammatory pathways and self-reported functional outcomes. However, extent of surgical resection was not significantly associated with reduction of inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…In healthy individuals, cortisol secretion follows a diurnal rhythm characterized by elevated levels in the morning which decline over the afternoon and evening, and reach a nadir during the first half of the night (Dallman et al 2000;Tsigos & Chrousos, 2002) Dysregulated patterns of cortisol secretion, often characterized by elevated nocturnal cortisol, have been noted in diverse populations of cancer patients including breast, ovarian, and cervical cancers and lymphoma (Abercrombie et al 2004;Jehn et al 2010;Mormont & Lévi, 1997;Palesh et al 2008) Elevated nocturnal cortisol and blunted diurnal cortisol slopehave been observed in ovarian cancer patients prior to surgery, a pattern that has been hypothesized to be secondary to tumor-derived inflammation (Lutgendorf et al 2008;Musselman et al 2001;Weinrib et al 2010) The specific effects of abnormal diurnal cortisol patterns on tumor physiology in humans are not known, although disruption of cortisol rhythms resulting in a flattened cortisol slope has been associated with shortened survival time in breast cancer patients (Sephton et al 2000). In animal models, the disrupted release of cortisol in response to inflammation is of substantial importance, as altered glucocorticoid receptor expression secondary to elevated cortisol has been identified as a potential mechanism in the initiation of ovarian cancer (Rae & Hillier, 2005), the failure of cancer cells to undergo apoptosis (Melhem et al 2009;Pan et al 2011;Schlossmacher et al 2011), the development of chemotherapy resistant ovarian cancer cells (Pang et al 2006), and accelerated tumor growth (Filipski & Lévi, 2009).…”

Section: Introductionmentioning

confidence: 99%

138. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability

Schrepf

Clevenger

Christensen

et al. 2012

Brain, Behavior, and Immunity

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Elevations in the pro-inflammatory cytokine interleukin-6 (IL-6) and alterations in the antiinflammatory hormone cortisol have been reported in a variety of cancers. IL-6 has prognostic significance in ovarian cancer and cortisol has been associated with fatigue, disability, and vegetative depression in ovarian cancer patients prior to surgery. Ovarian cancer patients © 2012 Elsevier Inc. All rights reserved.Corresponding Author: Susan K. Lutgendorf, Ph.D. Department of Psychology University of Iowa E11 Seashore Hall Iowa City IA 52242 PH: 319-335-2432 FX: 319-335-0191 susan-lutgendorf@uiowa.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public AccessAuthor Manuscript Brain Behav Immun. Author manuscript; available in PMC 2014 March 01. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript undergoing primary treatment completed psychological self-report measures and collected salivary cortisol and plasma IL-6 prior to surgery, at six months, and at one year. Patients included in this study had completed chemotherapy and had no evidence of disease recurrence. At six months, patients showed significant reductions in nocturnal cortisol secretion, plasma IL-6, and a more normalized diurnal cortisol rhythm, changes that were maintained at one year. The reductions in IL-6 and nocturnal cortisol were associated with declines in self-reported fatigue, vegetative depression, and disability. These findings suggest that primary treatment for ovarian cancer reduces the inflammatory response. Moreover, patients who have not developed recurrent disease by one year appear to maintain more normalized levels of cortisol and IL-6. Improvement in fatigue and vegetative depression is associated with the normalization of IL-6 and cortisol, a pattern which may be relevant for improvements in overall quality of life for ovarian cancer patients.

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Flattened cortisol rhythms in metastatic breast cancer patients

Cited by 260 publications

References 55 publications

Marital satisfaction, recovery from work, and diurnal cortisol among men and women.

Marital satisfaction, recovery from work, and diurnal cortisol among men and women.

Psychosocial factors associated with indices of cortisol production in women with breast cancer and controls

138. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability

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