Flat clathrin lattices are linked to metastatic potential in colorectal cancer

Cresens, Charlotte; Solís‐Fernández, Guillermo; Tiwari, Astha; Nuyts, Rik; Hofkens, Johan; Barderas, Rodrigo; Rocha, Susana

doi:10.1016/j.isci.2023.107327

Cited by 1 publication

(1 citation statement)

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“…For example, clathrin-mediated endocytosis is downregulated in multiple non-small cell lung cancer (NSCLC) cell lines compared to what is seen in normal lung epithelial cells ( Elkin et al, 2015 ). The dynamics and life-time of clathrin-coated pits are regulated by the tumour suppressor phosphatase and tensin homolog (PTEN) in breast cancer cell lines ( Rosselli-Murai et al, 2018 ) and the prevalence of flat clathrin lattices correlates with metastatic potential in colorectal cell lines ( Cresens et al, 2023 ). Moreover, upregulated expression of some endocytic proteins, such as HIP1 and dynamin-1 and -2, has been found to be pro-proliferative or anti-apoptotic ( Table 1 ).…”

Section: Adaptations In Endocytosis Support Tumour Growth and Metabol...mentioning

confidence: 99%

Adaptations of membrane trafficking in cancer and tumorigenesis

Evergren,

Mills,

Kennedy

2024

Journal of Cell Science

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Membrane trafficking, a fundamental cellular process encompassing the transport of molecules to specific organelles, endocytosis at the plasma membrane and protein secretion, is crucial for cellular homeostasis and signalling. Cancer cells adapt membrane trafficking to enhance their survival and metabolism, and understanding these adaptations is vital for improving patient responses to therapy and identifying therapeutic targets. In this Review, we provide a concise overview of major membrane trafficking pathways and detail adaptations in these pathways, including COPII-dependent endoplasmic reticulum (ER)-to-Golgi vesicle trafficking, COPI-dependent retrograde Golgi-to-ER trafficking and endocytosis, that have been found in cancer. We explore how these adaptations confer growth advantages or resistance to cell death and conclude by discussing the potential for utilising this knowledge in developing new treatment strategies and overcoming drug resistance for cancer patients.

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Section: Adaptations In Endocytosis Support Tumour Growth and Metabol...mentioning

confidence: 99%