FLASH Modalities Track (Oral Presentations) PROTON-FLASH: RADIATION EFFECTS OF ULTRAHIGH DOSE-RATE IRRADIATION

Rudigkeit, Sarah; Matejka, Nicole; Dombrowsky, Annique C.; Schmid, Thomas E.; Dollinger, G.; Reindl, Judith

doi:10.1016/s1120-1797(22)01528-9

Cited by 1 publication

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“…The very short time interval employed in FLASH-RT will reduce the fraction of cells in the circulation that are exposed to radiation. It has been estimated that 100 times more blood volume is subjected to irradiation by CONV-RT than by FLASH-RT and this large difference could account for a significant proportion of the reduced damage effected by FLASH-RT [55]. This difference may help to maintain immune surveillance in an effective state following FLASH rather than having it descend into non-targeted inflammation.…”

Section: Reduction Of Bystander Effects By Flashmentioning

confidence: 99%

FLASH Radiotherapy versus Conventional Therapy in Cancer Treatment; Promises, Paradoxes and Problems

Bondy,

2024

Preprint

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A novel means of applying radiotherapy in cancer treatment is the application of the radiation dose at a very high intensity for a very short time, FLASH radiotherapy (FLASH-RT). This technique involves exposure of tumors to >40 Gy/s, usually for less than one second. Studies conducted in cell and preclinical models suggest that FLASH-RT seems less damaging to normal tissues from adverse effects, relative to the same overall dose of radiation administered in conventional therapy (CONV-RT) which involves administration of lower levels of radiation repeated intermittently over a protracted period. In contrast, the susceptibility of tumor tissues to FLASH-RT is not diminished relative to CONV-RT. Within solid tumors both modes of dispensation of radiation produce an equivalent degree of cell damage. This differential between normal and malignant material has been found in isolated tissues, animal studies, and more recently in clinical trials. However, the classical radiation concept is that high energy linear transfer radiation (LET) is more damaging than the equivalent total dose of low LET. Thus, the susceptibility of cells should be greater to short-term exposure to high LET. This article discusses the potential reasons that may account for this discrepancy. While the relative protection given to untransformed tissues by FLASH-RT relative to tumor tissue is a major step forward in radiation therapy of cancer, the processes that lie behind this phenomenon are incompletely understood and are considered here.

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Section: Reduction Of Bystander Effects By Flashmentioning

confidence: 99%

FLASH Radiotherapy versus Conventional Therapy in Cancer Treatment; Promises, Paradoxes and Problems

Bondy,

2024

Preprint

View full text Add to dashboard Cite

show abstract

FLASH Modalities Track (Oral Presentations) PROTON-FLASH: RADIATION EFFECTS OF ULTRAHIGH DOSE-RATE IRRADIATION

Cited by 1 publication

References 0 publications

FLASH Radiotherapy versus Conventional Therapy in Cancer Treatment; Promises, Paradoxes and Problems

FLASH Radiotherapy versus Conventional Therapy in Cancer Treatment; Promises, Paradoxes and Problems

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