Flash imprint lithography using a mask aligner: a method for printing nanostructures in photosensitive hydrogels

Fozdar, David Y.; Zhang, Wande; Palard, Marylene; Patrick, C.; Chen, Shaochen

doi:10.1088/0957-4484/19/21/215303

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…Finally, the aligner electronically separated the mold from the glass slide leaving the patterned PEGDMA on the glass slide. The FILM process is reported in great detail in reference (Fozdar et al 2008). Fig.…”

Section: Imprinting Of Micro-wells In Pegdmamentioning

confidence: 99%

“…We chose the micro-well topographical theme based on the idea that the texture would enhance contact with PAs in culture and induce an atypical cell-response. We fabricate the microwell texture in PEG-dimethacrylate (PEGDMA) by a nanomanufacturing process recently developed by our group called Flash Imprint Lithography using a Mask Aligner (FILM) (Fozdar et al 2008). PEGDMA is a biocompatible liquid polymer that can be made to solidify upon exposure to ultraviolet light (365 nm i-line UV).…”

Section: Introductionmentioning

confidence: 99%

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Micro-well texture printed into PEG hydrogels using the FILM nanomanufacturing process affects the behavior of preadipocytes

Fozdar

Patrick

et al. 2008

Biomed Microdevices

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To date, biomaterial scaffolds for adipose tissue engineering have focused on macro- and upper micro-scale fabrication, biocompatibility, and biodegradation, but have failed to recapitulate the sub-micron dimensions of native extracellular matrix (ECM) and, therefore, have not optimized material-cell interactions. Here, we report the findings from a study investigating the effects of a quasi-mimetic sub-micron (< 1 micrometer) surface texture on the qualitative behavior of preadipocytes (PAs). We found that PAs in contact with tread-like micro-well structures exhibit a different morphology relative to PAs seeded onto control smooth glass surfaces. Additionally, the micro-well topography induced isolated PAs to undergo adipogenesis, which usually occurs in the presence of aggregates of contact-inhibited PAs. The micro-well structures were printed into polyethylene glycol dimethacrylate (PEGDMA) using the recently reported nanomanufacturing process called Flash Imprint Lithography Using a Mask Aligner (FILM). FILM is a simple process that can be utilized to fabricate micro- and nanostructures in UV-curable materials (D.Y. Fozdar, W. Zhang, M. Palard, C.W. Patrick Jr., S.C. Chen, Flash Imprint Lithography Using A Mask Aligner (FILM): A Method for Printing Nanostructures in Photosensitive Hydrogels for Tissue Engineering. Nanotechnology 19, 2008). We demonstrate the utilization of the FILM process for a tissue engineering application for the first time. The micro-well topographical theme is characterized by contact angle and surface energy analysis and the results were compared with those for smooth glass and unpatterned PEGDMA surfaces. Based on our observations, we believe that the micro-well texture may ultimately be beneficial on implantable tissue scaffolds.

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Section: Imprinting Of Micro-wells In Pegdmamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Micro-well texture printed into PEG hydrogels using the FILM nanomanufacturing process affects the behavior of preadipocytes

Fozdar

Patrick

et al. 2008

Biomed Microdevices

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“…The process was repeated to achieve a desired large sample. A bottom side of the quartz plate which was coated with a silane (tridecafluoro-1, 1, 2, 2-tetrahydrooctyl-1 tri-chlorosilane) (United Chemical Technologies, Bristol, PA, USA) that reduces the surface energy helped the releasing process [ 43 , 44 ].…”

Section: Methodsmentioning

confidence: 99%

A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio

et al. 2016

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Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio νxy (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson’s ratios of -0.6 ≤ νxy ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive νxy. Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.

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“…The responsive hydrogels are highly sensitive to changes in the environment and have been used in several applications, such as biosensors [46,[53][54][55], superabsorbent polymers [56][57][58], site-specific drug delivery systems [46,53,54,[59][60][61][62][63][64][65][66][67][68][69], emerging nanoscale technologies [70][71][72][73][74][75][76][77] and tissue engineering [16,[78][79][80][81][82][83][84][85][86][87][88][89]. Other important area for the use of polyelectrolytic hydrogels is bioand mucoadhesive drug delivery systems [90][91][92].…”

Section: Responsive Hydrogelsmentioning

confidence: 99%

Modular Hydrogels for Drug Delivery

Simões¹,

Figueiras²,

Veiga³

2012

JBNB

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The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body through minimally invasive means and, these vehicles should be capable of releasing drug to their intended location at a controlled rate. Furthermore, it is desirable to develop drug delivery systems that are capable of <i>in vivo</i> to suffer degradation and to deliver the drug completely, avoiding the need to surgically remove the vehicle at the end of its useful lifetime. Hydrogels are of particular interest for drug delivery applications due to their ability to address these needs in addition to their good biocompatibility, tunable network structure to control the diffusion of drugs and, tunable affinity for drugs. However, hydrogels are also limited for drug delivery applications due to the often quick elution of drug from their highly swollen polymer matrices as well as the difficulty inherent in the injection of macroscopic hydrogels into the body. This paper presents an overview to the advances in hydrogels based drug delivery. Different types of hydrogels can be used for drug delivery to specific sites in the gastrointestinal tract ranging from the oral cavity to the colon. These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations. Moreover, such materials are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues

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Flash imprint lithography using a mask aligner: a method for printing nanostructures in photosensitive hydrogels

Cited by 11 publications

References 17 publications

Micro-well texture printed into PEG hydrogels using the FILM nanomanufacturing process affects the behavior of preadipocytes

Micro-well texture printed into PEG hydrogels using the FILM nanomanufacturing process affects the behavior of preadipocytes

A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio

Modular Hydrogels for Drug Delivery

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