Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier

Hao, Rili; Zhang, Xing; Zhao, Xinyue; Lv, Xiaqing; Zhu, Xiangyang; Gao, NaNa; Jiang, Yang; Wu, Maoyu; Sun‐Waterhouse, Dongxiao; Li, Dapeng

doi:10.1016/j.scitotenv.2023.162910

Cited by 24 publications

(8 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Cd exposure could increase intestinal permeability, thereby disrupting the intestinal barrier and exacerbating intestinal damage ( 18 ). In addition, decreased expression of intestinal tight junction protein (ZO-1) induced by Cd exposure ( 9 , 19 ) was confirmed in our experiment. ZO-1 contributes to the repair of intestinal mucosal injury ( 19 ), and its reduced activity is related to enhanced intestinal permeability ( 13 , 18 ).…”

Section: Discussionsupporting

confidence: 82%

“…However, the mechanisms that trigger toxicity in vivo remain largely understudied. The intestine is one of the targets for Cd ( 13 ) and its exposure may induce intestinal inflammation ( 9 , 26 ), and increase the levels of inflammatory factors such as IL-6 and TNF-α in the blood and intestine. The correlation analysis revealed that the Clostridia_UCG_014 and NK4A214_groups were significantly and positively correlated with TNF-α in the intestine, and the altered composition of this microbiota could be related to the occurrence of intestinal inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in the composition of the gut microbiome can affect the pathology of peripheral organs in several ways ( 7 ), transfer functional biomolecules horizontally between bacterial and mammalian host cells by releasing the outer membrane vesicles (OMVs) ( 7 ), and affect the levels of short-chain fatty acids (SCFAs) by regulating energy metabolism ( 8 ). SCFAs are known to participate in Cd-induced intestinal inflammation and metabolic disturbance ( 9 ). In addition, the translocation of gut microbes from the gut to the blood circulation has been demonstrated by previous studies ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Environmental cadmium exposure alters the internal microbiota and metabolome of Sprague–Dawley rats

Liu¹,

Deng²,

Wang³

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Cadmium (Cd) is a toxic element that can negatively affect both humans and animals. It enters the human and animal bodies through the respiratory and digestive tracts, following which it tends to accumulate in different organs, thereby seriously affecting human and animal health, as well as hampering social and economic development. Cd exposure can alter the composition of intestinal microbiota. In addition, it can damage the peripheral organs by causing the translocation of intestinal microbiota. However, the relationship between translocation-induced changes in the composition of microbiome in the blood and metabolic changes remains unclear. In the present study, we investigated the effects of Cd exposure on microbiota and serum metabolism in rats by omics analysis. The results demonstrated that Cd exposure disrupted the balance between the blood and intestinal flora in Sprague–Dawley (SD) rats, with a significant increase in gut microbiota (Clostridia_UCG_014, NK4A214_group) and blood microbiome (Corynebacterium, Muribaculaceae). However, Cd exposure caused the translocation of Corynebacterium and Muribaculaceae from the gut into the blood. In addition, Cd exposure was associated with the up-regulation of serum indoxyl sulfate, phenyl sulfate, and p-cresol sulfate; down-regulation of δ-tocopherol and L-glutamine; and changes in blood microbiome and metabolites. In conclusion, we identified novel metabolic biomarkers for Cd toxicity, which will also expand our understanding of the role of blood microbiome in Cd-induced injury.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Environmental cadmium exposure alters the internal microbiota and metabolome of Sprague–Dawley rats

Liu¹,

Deng²,

Wang³

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…29 Globally, the adoption of dietary interventions has gained traction as a prevalent approach to counteract the consequences of widespread exposure to environmental risk factors, such as UVB irradiation. 30–32 Our findings highlight the favorable efficacy of dietary α-ionone intervention in mitigating the risks associated with skin photoaging stemming from chronic UVB exposure.…”

Section: Discussionmentioning

confidence: 73%

Dietary supplementation with α-ionone alleviates chronic UVB exposure-induced skin photoaging in mice

Geng,

Kang,

Huang

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…[11] Among them, plant polysaccharides can be obtained from Codonopsis pilosula, black fungus, Poria cocos, and Flammulina velutipes. [12][13][14][15] Mounting research has confirmed that PIC showed good water solubility, few side effects, high bioavailability, and stable physicochemical properties. [16] Besides, PIC has no toxicity at high concentrations.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

Dai,

Hao,

Gao

et al. 2023

Starch Stärke

View full text Add to dashboard Cite

Iron is an essential trace element in the human body. Iron deficiency can lead to iron deficiency anemia (IDA) and induce various diseases. Hence, it is urgent to find an iron supplement with minimal side effects and good iron supplementation effect. Natural polysaccharides from plants have various biological activities such as antioxidant, hypoglycemic, immunomodulatory, etc. Increasing research has shown that polysaccharides modified with iron can enhance their biological activities. Among them, polysaccharide iron complex (PIC) has significant anti‐anemia activity. With the powerfully development of PIC, increasing research has found that PIC showed some advantages, including good water solubility, high bioavailability, low gastrointestinal irritation, and high iron content. Therefore, PIC has received widespread attention. Currently, PIC is widely used in various fields such as agriculture, animal husbandry, and clinical treatment. However, there are limited reports on the preparation, biological activities, and applications of PIC. This paper systematically reviews the preparation methods, iron content determination methods, biological activities, and applications of PIC. The results provide important references for the deep development and utilization of PIC.

show abstract

Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier

Cited by 24 publications

References 59 publications

Environmental cadmium exposure alters the internal microbiota and metabolome of Sprague–Dawley rats

Environmental cadmium exposure alters the internal microbiota and metabolome of Sprague–Dawley rats

Dietary supplementation with α-ionone alleviates chronic UVB exposure-induced skin photoaging in mice

Preparation, Biological Activities, and Application of Plant Polysaccharide Iron Complexes: A Review

Contact Info

Product

Resources

About