Flagyl (Metronidazole)

Durel, P; Couture, J.; Collart, P.; Girot, C.

doi:10.1136/sti.36.3.154

Cited by 13 publications

(12 citation statements)

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“…Coincidentally, clinical and in vitro resistance to the drug in Trichomonas vaginalis (Müller et al, 1980 ; Wright et al, 2010 ), Giardia lamblia (Müller et al, 2007 ; Tejman-Yarden et al, 2011 ), Blastocystis spp. (Mirza et al, 2011a , b ), Neisseria gonorrhoeae (Yoshikawa et al, 1974 ), and several anaerobic bacteria (Pumbwe et al, 2007 ; Peláez et al, 2008 ; Tanih et al, 2011 ) have also been reported since the drug was introduced in 1960 (Figure S1 ) (Durel et al, 1960 ). Based on these findings, it is reasonable to assume that clinical resistance to MTZ might soon be reported in E. histolytica .…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance

2015

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Antimicrobial chemotherapy is critical in the fight against infectious diseases caused by Entamoeba histolytica. Among the drugs available for the treatment of amebiasis, metronidazole (MTZ) is considered the drug of choice. Recently, in vitro studies have described MTZ resistance and the potential mechanisms involved. Costs to fitness and adaptive responses associated with resistance, however, have not been investigated. In this study we generated an HM-1 derived strain resistant to 12 μM MTZ (MTZR). We examined its phenotypic and transcriptional profile to determine the consequences and mRNA level changes associated with MTZ resistance. Our results indicated increased cell size and granularity, and decreased rates in cell division, adhesion, phagocytosis, cytopathogenicity, and glucose consumption. Transcriptome analysis revealed 142 differentially expressed genes in MTZR. In contrast to other MTZ resistant parasites, MTZR did not down-regulate pyruvate:ferredoxin oxidoreductase, but showed increased expression of genes for a hypothetical protein (HP1) and several iron-sulfur flavoproteins, and downregulation of genes for leucine-rich proteins. Fisher's exact test showed 24 significantly enriched GO terms in MTZR, and a 3-way comparison of modulated genes in MTZR against those of MTZR cultured without MTZ and HM-1 cultured with MTZ, showed that 88 genes were specific to MTZR. Overall, our findings suggested that MTZ resistance is associated with specific transcriptional changes and decreased parasite virulence.

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Section: Introductionmentioning

confidence: 99%

Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance

2015

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“…Metronidazole (500 mg) vaginal tablets (Tergynan) or ovules (Flagyl) are commonly used for the treatment of vaginal trichomoniasis. The classical treatment schedule consists of one application per day for 10 days (109)(110)(111).…”

Section: Vaginally Applied Formulations For Treatment Of T Vaginalismentioning

confidence: 99%

Strategies for Prevention and Treatment of Trichomonas vaginalis Infections

2017

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“…Currently, the compound of choice for the treatment of T. vaginalis infections is metronidazole (MTZ), which has been effectively used since the 1960s (Durel et al 1960). However, an increase in MTZ-resistant trichomoniasis has been observed (Lossick and M uller M and Gorrell TE, 1986).…”

Section: Introductionmentioning

confidence: 99%

Effect of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin on the ultrastructure of Trichomonas vaginalis trophozoites

2014

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Trichomonas vaginalis is a parasitic protozoan that is the aetiological agent of trichomoniasis, the most common non-viral sexually transmitted disease worldwide. Currently, the compound of choice for the treatment of T. vaginalis infections is metronidazole, however, it has many side effects and an increase in metronidazole-resistant trichomoniasis has been observed. Medicinal plants could be a source of new antiprotozoal drugs with high activity, low toxicity and lower price. The present work was carried out to investigate the therapeutic potential of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin and their in vitro activity on the ultrastructure of T. vaginalis trophozoites in comparison to metronidazole, as detected by transmission electron microscope. Both N. sativa oil and P. vulgaris lectin showed high toxic effect as evidenced by severe cell damage with cytoplasmic and nuclear destruction, while the effect of N. sativa alcoholic extract was moderate. Therefore, these two extracts could offer an effective, cheaper and more safe alternative for metronidazole in treatment of trichomoniasis.

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Flagyl (Metronidazole)

Cited by 13 publications

References 0 publications

Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance

Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance

Strategies for Prevention and Treatment of Trichomonas vaginalis Infections

Effect of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin on the ultrastructure of Trichomonas vaginalis trophozoites

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