FKBP5 and Attention Bias for Threat

Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion

“…In addition, a recent study in a clinical cohort has demonstrated a link between FKBP51 and stress-related psychiatric disorders. 40 Our results further support previous data showing decreased expression of BDNF in the PFC of rats deprived of n-3 PUFAs for 15 weeks. 41 Recent data have elegantly linked BDNF and HPA axis activity by using knock-in mice for BDNF(met) polymorphism originally identified in depressed patients.…”

Genetic Variations in COMT and DRD2 Modulate Attentional Bias for Affective Facial Expressions

“…Moreover, in the present study, COMT Val158Met and DRD2 TaqIA only accounted for 1.00% and 2.00% variances of attentional bias for facial expressions. This genetic power approximately equaled to the previous results which indicated a certain single genetic loci could explain subtle a variance in attentional bias [49] , [65] , [66] , [67] , [68] . The results further indicated that attentional bias was a polygenetic trait and each of the genes exerts a subtle effect on the individual difference although it has a substantial heritability [57] .…”

“…The results further indicated that attentional bias was a polygenetic trait and each of the genes exerts a subtle effect on the individual difference although it has a substantial heritability [57] . COMT and DRD2 , as well as 5-HTTLPR , ADRA2B , DBH and MAOA in previous studies [49] , [65] , [66] , [68] , were a small part of the candidate genes underlying the individual differences of attentional bias because of the complex phenotype including many components such as facilitated engagement, delayed disengagement, attentional controlling and emotional regulation [47] . Therefore, more genetic loci in dopaminergic and serotoninergic systems should be selected in the future investigation.…”

Narrative Review: A Neurobiological Perspective on Resilience in Youth

“…The more common alleles of two out of the six tested FKBP5 haplotypes, previously shown to protect against psychiatric symptoms, demonstrated protection against dorsal amygdala reactivity in the setting of emotional neglect. These findings in youth converge with neuroimaging studies in adults which show that the more common FKBP5 variants are associated with less hippocampal activation (86) . Implications of this line of work is that FKBP5 polymorphisms and early life environment interact in multiple stressregulating brain regions.…”