FK506 Enhances fibrogenesis in in vitro and in vivo models of liver fibrosis in rats

Clinical outcome of HCV-related graft cirrhosis and prognostic value of hepatic venous pressure gradient

“…This different rate of progression could be associated with the initial use of tacrolimus versus cyclosporine as cyclosporine has an in vitro antiviral effect (however this is at pharmacologic doses 0.5-1 lg/ml) [41,42] and a possible differential effect on fibrogenesis [43,44]. However, the use of calcineurin inhibitors in our cohort was also associated with different uses of azathioprine and prednisolone in the initial immunosuppression whose longterm use we have found 'protective' with regard to developing fibrosis [11].…”

Impact of immunosuppression on immunopathogenesis of liver damage in hepatitis C virus-infected recipients following liver transplantation

“…40,41 These effects have the potential to improve outcomes for progressive HCV disease posttransplantation and deserve direct study because such drugs as tacrolimus have profibrotic effects in such studies. 42 …”

Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts

“…Wolf e t a l. (1990) reported that cyclosporin A stimulated collagen synthesis and gene expression in kidney fibroblasts and tubular cells. Frizell et al (1994) reported that another PP2B inhibitor FK506 also increased the expression of extracellular matrix genes. Here we reported that FN, one of the important extracellular matrix proteins, are also upregulated by cyclosporin A and ascomycin suggesting that the increased synthesis of FN by them may contribute to the tissue fibrosis which is one of major side effects of these immunosuppressant drugs.…”