In this paper, using the fixed point method, we prove some results related to the generalized Hyers-Ulam stability of homomorphisms and derivations in non-Archimedean random C *-algebras and non-Archimedean random Lie C *-algebras for the generalized additive functional equation 1≤i< j≤n f x i + x j 2 + n−2 l=1, k l i,j x k l = (n − 1) 2 2 n i=1 f (x i) where n ∈ N is a fixed integer with n ≥ 3.