Fixed Low-Dose Antihypertensive Therapy

Woodham, Ryan M.; Oparil, Suzanne

doi:10.1016/b978-0-323-03961-1.50089-1

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…20,24 However, the absolute difference between the two genders was clinically small (1.2%), possibly because of convenience of using fixed-dose combination therapies. 41 As male constitutes the major working population in highly industrialized Asian regions such as Hong Kong, they were less likely to be regular clinic attendees.…”

Section: From 29 253mentioning

confidence: 99%

Adherence to combination therapy among ethnic Chinese patients: a cohort study

2010

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Discontinuation of antihypertensive combination therapy imposes a substantial public health burden, but few studies have addressed the factors associated with their discontinuation in Chinese patients. This study evaluated the association between patient age, gender, and number of comorbidities with discontinuation of combination therapies. From clinical databases, we included all adult patients prescribed an antihypertensive fixed-dose combination therapy during January 2004 to June 2007 in any government primary care clinics in one large Territory of Hong Kong. We studied the factors associated with drug discontinuation within 180 days after the first prescription date by multivariable regression analysis, controlling for age, gender, socioeconomic status, service setting, district of residence, visit types (new vs. follow-up), and the number of comorbidities. From 29 253 eligible patients, 7.1% discontinued their antihypertensive prescriptions. Younger (<50 years; adjusted odds ratios [aOR]: 0.78, 95% confidence interval [CI]: 0.66-0.92 for patients aged 50-59 years, P=0.003; aOR: 0.71, 95% CI: 0.60-0.84 for patients aged 60-69 years, P<0.001) and male patients (aOR: 1.19, 95% CI: 1.08-1.31, P<0.001) were more likely to have drug discontinuation. Patients with one (aOR: 0.64, 95% CI: 0.57-0.73, P<0.001) and at least two (aOR: 0.68, 95% CI: 0.54-0.87, P=0.002) comorbidities were less likely to have their medications discontinued. Combination therapies in Chinese patients had a low discontinuation rate when compared with Caucasian patients. Discontinuation was more likely among younger, male patients and those without concomitant comorbidities, in which more meticulous monitoring of their adherence patterns was needed.

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Section: From 29 253mentioning

confidence: 99%

Adherence to combination therapy among ethnic Chinese patients: a cohort study

2010

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“…Initiating therapy with more than one agent offers the potential advantages of achieving BP control more rapidly and avoiding dose-related adverse effects of individual drugs by producing greater BP reductions at lower doses of the component agents. Fixed-dose combinations also have other advantages (Table 1) (Lewanczuk and Tobe 2007;Woodham and Oparil 2007).…”

Section: Patient Adherencementioning

confidence: 99%

Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan – amlodipine combination

Pimenta

Oparil²

2008

VHRM

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Abstract:Although the awareness and control of hypertension has increased, only 37% of hypertensive patients in the US achieve the conservative goal of Ͻ140/90 mmHg. Achieving optimal blood pressure (BP) control is the most important single issue in the management of hypertension, and in most hypertensive patients, it is diffi cult or impossible to control BP with one drug. Blocking two or more BP regulatory systems provides a more effective and more physiologic reduction in BP, and current guidelines have recommended the use of combination therapy as fi rst-line treatment, or early in the management of hypertension. Fixed combination therapy is an effi cacious, relatively safe, and may be cost-effective method of decreasing BP in most patients with essential hypertension. Similar to other combinations, fi xed-dose combination tablets containing the dihydropyridine calcium channel blocker amlodipine and the angiotensin II receptor blocker olmesartan bring together two distinct and complementary mechanisms of action, resulting in improved BP control and potential for improved target organ protection relative to either class of agent alone.

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Factors Associated With Antihypertensive Drug Discontinuation Among Chinese Patients: A Cohort Study

Wong

Jiang

Gibbs

et al. 2009

American Journal of Hypertension

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Fixed Low-Dose Antihypertensive Therapy

Cited by 3 publications

References 78 publications

Adherence to combination therapy among ethnic Chinese patients: a cohort study

Adherence to combination therapy among ethnic Chinese patients: a cohort study

Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan – amlodipine combination

Factors Associated With Antihypertensive Drug Discontinuation Among Chinese Patients: A Cohort Study

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Fixed Low-Dose Antihypertensive Therapy

Cited by 3 publications

References 78 publications

Adherence to combination therapy among ethnic Chinese patients: a cohort study

Adherence to combination therapy among ethnic Chinese patients: a cohort study

Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan &ndash; amlodipine combination

Factors Associated With Antihypertensive Drug Discontinuation Among Chinese Patients: A Cohort Study

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Fixed combinations in the management of hypertension: patient perspectives and rationale for development and utility of the olmesartan – amlodipine combination