Fixed Drug Eruption Induced by Pristinamycin and Amoxicillin–Clavulanic Acid: An Unusual Case of Cosensitization

Ammar, Helmi; Romdhane, Haifa Ben; Fadhel, Najeh Ben; Chadli, Zohra; Boughattas, Naceur A.; Fredj, Nadia Ben; Aouam, Karim

doi:10.1097/der.0000000000000775

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“…3,4,6 Cross-reactivity in the case of FDE has been largely described among various drugs sharing the same chemical structure, such as tetracycline derivatives, 12 antifungal azoles, 13 quinolones, 14 antihistamines, 15 nitroimidazole derivatives 16 and cyclines. 17 In addition, cross-reactivity in cases of FDE has been described between two distinct drug families, 18 between NSAIDs and antibiotics such as between coxibs and sulfonamides, 19 metamizole and tetracycline, 20,21 trimethoprim-sulfamethoxazole and tenoxicam. 22 Among NSAIDs, cross-reactivity in cases of FDE has been described between those sharing the same chemical structure, that is, among the oxicam group [23][24][25][26][27] (piroxicam, tenoxicam and meloxicam) and between oxyphenbutazone and phenylbutazone.…”

Section: Discussionmentioning

confidence: 99%

“…Cross‐reactivity in the case of FDE has been largely described among various drugs sharing the same chemical structure, such as tetracycline derivatives, 12 antifungal azoles, 13 quinolones, 14 antihistamines, 15 nitroimidazole derivatives 16 and cyclines 17 . In addition, cross‐reactivity in cases of FDE has been described between two distinct drug families, 18 between NSAIDs and antibiotics such as between coxibs and sulfonamides, 19 metamizole and tetracycline, 20,21 trimethoprim‐sulfamethoxazole and tenoxicam 22 …”

Section: Discussionmentioning

confidence: 99%

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Cross‐reactivity between nonsteroidal anti‐inflammatory drugs in fixed drug eruption: Two unusual cases and a literature review

Ammar

Fredj

Romdhane

et al. 2022

Brit J Clinical Pharma

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Nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the main causes of fixed drug eruption (FDE). Cross‐sensitivity between chemically unrelated NSAIDs has been rarely described in FDE. We report herein two cases of NSAID‐induced FDE confirmed by oral provocation test (OPT) with a literature review. Case 1 is a 49‐year‐old woman who took mefenamic, naproxen and acetaminophen for lumbago. On the second day, she noticed three erythematous plaques, located in the upper lip, chin and the right hand, which faded spontaneously, leaving residual patches. Three months later, she took mefenamic acid with reactivation of the same plaques. She received naproxen. On the same day, she exhibited a reactivation of lesions with the development of a new one. These lesions have disappeared leaving hyperpigmented sequelae. After negative patch test to naproxen, an OPT was performed with positive reaction, observed on the third day. To establish the cross‐reactivity, she underwent OPTs, which gave positive results to indomethacin, ketoprofen and tiaprofenic acid. Case 2 is a 52‐year‐old woman who presented painful dusky‐red macules, located in the right and left wrists, 24 hours after taking mefenamic acid. She described two similar events that occurred in the past with an undefined drug and piroxicam. Patch tests to lysine acetylsalicylate, mefenamic acid, piroxicam, naproxen and celecoxib were negative. OPTs to the same NSAIDs gave positive results to lysine acetylsalicylate, piroxicam and mefenamic acid. Thirteen case reports, seven case series and one retrospective analysis, including cases with confirmed cross‐reactivity between NSAIDs, were reported in literature. Clinicians should be aware of such phenomenon.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cross‐reactivity between nonsteroidal anti‐inflammatory drugs in fixed drug eruption: Two unusual cases and a literature review

Ammar

Fredj

Romdhane

et al. 2022

Brit J Clinical Pharma

Self Cite

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Fixed Drug Eruption Induced by Pristinamycin and Amoxicillin–Clavulanic Acid: An Unusual Case of Cosensitization

Abstract: 2. Vine K, DeLeo V. Dermatologic manifestations of musicians: a case report and review of skin conditions in musicians.

Cited by 1 publication

References 6 publications

Cross‐reactivity between nonsteroidal anti‐inflammatory drugs in fixed drug eruption: Two unusual cases and a literature review

Cross‐reactivity between nonsteroidal anti‐inflammatory drugs in fixed drug eruption: Two unusual cases and a literature review

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