Fixed drug eruption due to clindamycin with tolerance to lincomycin

Cross‐reactivity to lincomycin in patients with maculopapular exanthem to clindamycin: A case series

“…1 Also, in another case report of a documented type IV allergic reaction after clindamycin intake, presenting as FDE, the patient tolerated lincomycin afterwards. 2 Our finding does not seem to be surprising given the structural similarity between the two drugs but seems to be inconsistent with the aforementioned reports regarding IHRs…”

“…In a previous case report of a documented IgE‐mediated reaction to clindamycin no cross‐reactivity with lincomycin was found, and the patient tolerated its administration 1 . Also, in another case report of a documented type IV allergic reaction after clindamycin intake, presenting as FDE, the patient tolerated lincomycin afterwards 2 …”

“…PTs were performed with clindamycin 150 mg/mL 10% in petrolatum as described elsewhere. 2 The preparation was mounted on AllergEAZE patch test chambers (SmartPractice, Calgary, Canada), applied on the upper back, and occluded with Fixomull stretch (BSN Medical, Hamburg, Germany) for 2 days. Readings were taken after 72 h and 1 week, and results were interpreted according to the International Contact Dermatitis Research Group criteria.…”

“…Although the latter medical devices are an older form of contraception, their popularity appears to be increased as opposed to hormonal contraception. 1,2 We present a case of systemic allergic dermatitis, manifesting as vesicular (dyshidrotic) hand eczema, following the use of a copper-containing IUD.…”

“…Tests were read after 48 h and considered positive in case of appearance of induration with diameter greater than 5 mm surrounded by erythema. PTs were performed with clindamycin 150 mg/mL 10% in petrolatum as described elsewhere 2 . The preparation was mounted on AllergEAZE patch test chambers (SmartPractice, Calgary, Canada), applied on the upper back, and occluded with Fixomull stretch (BSN Medical, Hamburg, Germany) for 2 days.…”