Fixed‐drug eruption caused by allylisopropylacetylurea

Non‐pigmenting fixed drug eruption caused by allylisopropylacetylurea

“…Therefore, we concluded that allylisopropylacetylurea was the causative agent. Recently, there have been accumulating reports of drug eruptions caused by allylisopropylacetylurea in Japan (1, 3–5), and among them, the multiple type of FDE is the most common (77%) (5).…”

“…Additionally, bromvalerylurea, which has a chemical structure similar to that of allylisopropylacetylurea (Fig. 1b) and is contained in 17% of Japanese over‐the‐counter analgesics, has been reported to show cross‐sensitivity to allylisopropylacetylurea (4). It is important for doctors not only to recommend that patients refrain from taking the causative drugs but also to suggest safe alternative drugs.…”

“…In Japan, 57 over-the-counter drugs containing allylisopropylacetylurea are currently available (2). Recently, there have been increasing numbers of reports of fixed drug eruptions (FDEs) caused by such drugs (3)(4)(5).…”

Drug patch testing in systemic cutaneous drug allergy

“…Miscellaneous drugs have been reported as yielding CADR with positive drug patch tests (Barbaud et al, 1998b;Barbaud, 2003): acyclovir and valaciclovir (Lammintausta et al, 2001;Vernassiere et al, 2003), allylisopropylacetylurea in a FDE (Sakakibara et al, 2001), captopril (Barbaud et al, 1998b), cefcapene pivoxil (Kawada et al, 2001), celecoxib (Britschgi et al, 2001;Verbeiren et al, 2002), clobazam (Machet et al, 1992), codeine diluted at 1 and 5% in petrolatum (two negative controls) (Estrada et al, 2001), co-trimoxazole (Klein et al, 1995), cyamemazine (Barbaud et al, 1998b), diazepam (Felix and Comaish, 1974), diclofenac (Jonker and Bruynzeel, 2003;Romano et al, 1994), enoxoparin (Barbaud et al, 1998b), estrogens (Gonçalo et al, 1999), fluoroquinolones (Barbaud et al, 1998b;Rodriguez-Morales et al, 2001), fusafungine (Barbaud et al, 1998b), isoniazide at 50% in petrolatum (10 negative controls) (Rebello et al, 2001), Lamisil ® (Barbaud et al, 1998b), meprobamate (Barbaud et al, 2001a), metamizole at 1 and 10% in petrolatum (Gonzalo-Garijo et al, 2001;Quinones Estevez, 2001), mexiletine hydrochloride diluted at 10 and 20% in petrolatum (Sasaki et al, 2001), nystatin at 10% in petrolatum (10 negative controls) (Barranco et al, 2001), paracetamol (acetaminophen) (Mashiah and Brenner, 2003) and vancomycin at 0.005% in water (Bernedo et al, 2001).…”

Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions

“…Miscellaneous drugs have been reported as yielding CADR with positive drug patch tests [2,4,31] : acyclovir and valacyclovir [21,83] , allylisopropylacetylurea in a FDE [84] , captopril at 1 and 10% in petrolatum [2,85] , cefcapene pivoxil [86] , celecoxib [12,87] , clindamycin [31] , clobazam [88] , chlorphenamine (20% in petrolatum) [89] , codeine diluted at 1 and 5% in petrolatum (2 negative controls) [90] , cotrimoxazole [22,25] , cyamemazine [23] , diazepam [3,52] , diclofenac [28,91] , enoxoparin [2,3] , estrogens [20] , fluindione [92] , fluoroquinolones [2,3,[93][94][95] , fusafungine [2] , gentamycin [31] , isoniazide at 50% in petrolatum (10 negative controls) [31,96] , Lamisil [2,3] , meprobamate [2,3] , metamizole at 1 and 10% in petrolatum [97,98] , metronidazole [31] , mexiletine hydrochloride diluted at 10 and 20% in petrolatum [99] , minocyclin [100] , nimesulide …”