Fixed cutaneous sporotrichosis in a patient with numerous fungal elements

Gu, Ankang; Zhang, Xiujun; Ma, Faku; Nie, Zhenhua; Hoog, G. Sybren de

doi:10.1016/j.mmcr.2020.06.001

Cited by 4 publications

(8 citation statements)

References 16 publications

(23 reference statements)

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“…In most sporotrichosis cases, histopathological detection of the etiologic agent is difficult due to a low fungal load, with abundant cells being occasionally found in tissues only. 16 For this patient, we were unable to identify the fungal cells on the histological slides.…”

Section: Discussionmentioning

confidence: 93%

“…Sporotrichosis is a chronic, granulomatous, subcutaneous infection caused by dimorphic members of the genus Sporothrix, including at least six sibling phylogenetic species: S. pallida, S. brasiliensis, S. globosa, S. luriei, S. mexicana , and S. schenckii . 16 In China, S. globosa is predominant, 7–9 , 11 except for in the Nanchang area, where S. schenckii occurs along with S. globosa. 16 …”

Section: Discussionmentioning

confidence: 99%

“… 16 In China, S. globosa is predominant, 7–9 , 11 except for in the Nanchang area, where S. schenckii occurs along with S. globosa. 16 …”

Section: Discussionmentioning

confidence: 99%

“…In vitro antifungal susceptibility tests with fluconazole, itraconazole, voriconazole caspofungin, and amphotericin B were performed using the E-test method as previously described. 15…”

Section: Patients and Methods Casementioning

confidence: 99%

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Fixed Cutaneous Sporotrichosis Due to Sporothrix globosa

Liu¹,

Liu²,

Yuan³

et al. 2021

CCID

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Purpose: This report describes a case of a skin sporotrichosis infection and the steps taken to identify an effective antifungal treatment. Patients and Methods: A 50-year-old woman from Jilin province, China, presented complaining of a small mass that had been on her right upper eyelid for two years. A skin biopsy was taken and submitted for bacterial and mycological assessment. Bacterial culture from the lesion was negative, but a fungal culture was positive. In vitro susceptibility test was performed to assess its susceptibility to antifungal drugs. Results: The skin biopsy showed infectious granuloma. Fungal culture was identified as Sporothrix globosa based on both the morphological features and confirmation by the molecular method; it was resistant to many kinds of antifungal drugs, including amphotericin B, voriconazole, fluconazole, and caspofungin. However, it was relatively sensitive to itraconazole. The patient was prescribed 0.2 g itraconazole to be taken twice per day. One month later, she had almost completely recovered from her symptoms. The treatment lasted for 3 months and her liver function and renal function were normal at the endpoint. Conclusion:Itraconazole was an effective treatment in this case of a multidrug-resistant sporotrichosis caused by S. globosa.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“… 16 In China, S. globosa is predominant, 7–9 , 11 except for in the Nanchang area, where S. schenckii occurs along with S. globosa. 16 …”

Section: Discussionmentioning

confidence: 99%

“…In vitro antifungal susceptibility tests with fluconazole, itraconazole, voriconazole caspofungin, and amphotericin B were performed using the E-test method as previously described. 15…”

Section: Patients and Methods Casementioning

confidence: 99%

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Fixed Cutaneous Sporotrichosis Due to Sporothrix globosa

Liu¹,

Liu²,

Yuan³

et al. 2021

CCID

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“…The fungus is usually present only in small numbers. Consequently, isolating the fungus in culture is sometimes difficult, but it may be necessary to differentiate between various species as they respond differently to antifungal therapy [ 8 ]. Although the first treatment of choice is itraconazole, for cutaneous-lymphatic and cutaneous-fixed sporotrichosis, potassium iodide is reported to have a favorable response when administered in diluted solutions or drops of saturated solution [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Rash in the Emergency Department: Sporothrix schenckii

Shah¹,

Kim²,

Elbadri³

et al. 2021

Cureus

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The authors present a case of Sporothrix schenckii diagnosed in the emergency department, based on a thorough history. The patient presented with skin nodules that had spread proximally up the arm in various stages of healing. He reported minimal pain for the unhealed ulcer and no pain for the healing ulcers, and no other concerning symptoms. The history of a thorn prick followed by the initial red nodule on the forearm has led to the diagnosis -as it was consistent with the classic presentation of lymphocutaneous sporotrichosis. A high index of suspicion and carefully noting occupational history is required for a diagnosis of sporotrichosis. Clinicians should recommend long sleeves and gloves to their patients when they are handling soil.

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Superficial mycoses, a matter of concern: Global and Indian scenario‐an updated analysis

Sharma

Nonzom

2021

Mycoses

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Superficial mycoses are the fungal infections restricted to the outermost non-living layers of the skin and its appendages viz., hair and nails. Their prevalence rate has been reported to be 20%-25% 1 and vary with respect to occupational groups, gender, age group, etc. These infections are more common in tropical as well as subtropical countries where heat, humidity and other favourable conditions aid in their acquisition and maintenance. Although superficial mycotic infections are usually limited to the skin and mucous membranes, these infections are hardly life-threatening but they have importance because of their worldwide distribution, morbidity and transmission from one person/animal to another.Over the last decades, it has been observed that an increasing number of non-dermatophytic fungi, like, Alternaria, Aspergillus, Chaetomium, Curvularia, Fusarium, Penicillium, Scopulariopsis and Trichosporon, have also emerged as causal agents of superficial mycoses in humans, producing almost clinically similar lesions as caused by dermatophytes. 2,3 Although both dermatophytes and non-dermatophytes have been known to cause superficial mycoses all over the world, their incidence, distribution, prevalence, epidemiology, clinical manifestation and target hosts may vary from region to region. 4,5 In this review, more emphasis has been provided on information related to skin and hair infections.

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Fixed cutaneous sporotrichosis in a patient with numerous fungal elements

Cited by 4 publications

References 16 publications

Fixed Cutaneous Sporotrichosis Due to Sporothrix globosa

Fixed Cutaneous Sporotrichosis Due to Sporothrix globosa

An Uncommon Rash in the Emergency Department: Sporothrix schenckii

Superficial mycoses, a matter of concern: Global and Indian scenario‐an updated analysis

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