Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis

Zeng, Yu; Sang, Jianfeng

doi:10.18632/oncotarget.21620

Cited by 6 publications

(9 citation statements)

References 36 publications

(42 reference statements)

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“…1 School of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, China. 2 Beijing National Biochip Research Center Sub-Center in Ningxia, The General Hospital of Ningxia Medical University, Yinchuan 750004, China. 3 Medical Animal Lab, The Affiliated Hospital of Qingdao University, Qingdao 266003, China.…”

Section: Author Detailsmentioning

confidence: 99%

“…The latest survey shows more than 2000 million newly diagnosed patients of breast cancer have occurred in the worldwide. And the incidence and mortality of breast cancer have increased by nearly 18% since 2008 [2]. Breast cancer is a diverse hormone-dependent carcinoma, with both genetic and epigenetic changes leading to initiation, progression and metastasis [3].…”

Section: Introductionmentioning

confidence: 99%

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PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells

Cao¹,

Wang²,

Wang³

et al. 2019

Cancer Cell Int

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Background: Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully understood and the function requires to be further elucidated. Methods: mRNA and protein expression of PGC-1β and FOXA2 in breast cancer tissues and cell lines were determined by qRT-PCR and Western Blotting, respectively. To further visualize the expression and localization of PGC-1β and FOXA2, immunochemistry and immunofluorescence staining methods were employed. The effect of PGC-1β and FOXA2 on cell proliferation and migration were evaluated by CCK8, clone formation, transwell and wound-healing assays, which has been done either with stable PGC-1β knockdown or FOXA2 overexpression in vitro. Xenografts model of nude mice were used to evaluate tumor growth in vivo. In addition, proteins expression of the PI3K-AKT-mTOR signaling pathway involved in the regulation of breast cancer were detected by Western Blotting. Results: Our results showed that PGC-1β was upregulated and FOXA2 was downregulated in breast cancer tissues and cell lines. These two proteins can be interacted with each other to form the complex. Also, we found the combination of PGC-1β interference with FOXA2 overexpression significantly inhibited cell proliferation and migration in vitro as well as tumor growth in vivo. We further identified that PGC-1β and FOXA2 strongly correlated with the PI3K-AKT-mTOR signaling pathway, and they exerted their biological functions by activating this pathway. Conclusions: We demonstrated that downregulation of PGC-1β combined with overexpression of FOXA2 obviously inhibited the function of breast cancer cells through regulating the PI3K-AKT-mTOR pathway.

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Section: Author Detailsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells

Cao¹,

Wang²,

Wang³

et al. 2019

Cancer Cell Int

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“…Based on these data, we were particularly interested in ZNF350 encoding zinc finger protein 350 (ZNF350/ZBRK1) that has been suggested to function as a tumor suppressor, namely repression of metastasis/invasion, via interaction with breast cancer 1 (BRCA1) and KRAB-ZFP-associated protein 1 (KAP1) [15]. Notably, ZNF350 mRNA expression in the MG cells was reduced to 13% compared to that in non-MG cells (Figure 6A), and treatment with 5-azacytidine increased its expression by 8-fold (Figure 6B).…”

Section: Resultsmentioning

confidence: 99%

ZNF350 promoter methylation accelerates colon cancer cell migration

et al. 2018

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Diversification of transcriptomic and epigenomic states may occur during the expansion of colorectal cancers. Certain cancer cells lose their epithelial characters and gain mesenchymal properties, known as epithelial-mesenchymal transition (EMT), and they aggressively migrate into the non-tumorigenic extracellular matrix. In this study, we isolated a subpopulation with accelerated baseline motility (MG cells) and an immotile one (non-MG cells) from a colon cancer cell line (HCT116). Gene expression signatures of the MG cells indicated that this subpopulation was likely an EMT hybrid. The MG cells substantially lost their migratory properties after treatment with a methyltransferase inhibitor, 5-azacytidine, suggesting a role of DNA methylation in this process. Global transcriptome assays of both types of cells with or without 5-azacytidine treatment identified 640 genes, whose expression might be methylation-dependently down-regulated in the MG cells. Global methylation analysis revealed that 35 out of the 640 genes were hyper-methylated in the MG cells. Among them, we focused on the anti-oncogene ZNF350, which encodes a zinc-finger and BRCA1-interacting protein. Notably, ZNF350 knockdown accelerated migration of the non-MG cells, while overexpression of ZNF350 in the MG cells significantly impaired their migration. Finally, pyrosequence analysis together with dual luciferase assays of serially truncated fragments of the ZNF350 promoter (-268 to +49 bp) indicated that three hyper-methylated sites were possibly responsible for the basal promoter activity of ZNF350. Taken together, our results suggest that hyper-methylation of the ZNF350 proximal promoter may be one of the crucial determinants for acquiring increased migratory capabilities in colon cancer cells.

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“…Even though it was not the purpose of the present paper to decipher a diagnostic tool, a useful contribution of elemental analysis to diagnostic is supported by the role trace element have in some enzymes involved in disease progression, e.g. metalloproteinases 54 as well as in many zinc finger motives involved in reprogramming breast cancer transcriptional network 55,56 related to metastasis.…”

Section: Discussionmentioning

confidence: 98%

An Innovative Platform Merging Elemental Analysis and Ftir Imaging for Breast Tissue Analysis

Ali

Rakib

Al‐Saad

et al. 2019

Sci Rep

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Histopathology and immunohistology remain the gold standard for breast cancer diagnostic. Yet, these approaches do not usually provide a sufficiently detailed characterization of the pathology. The purpose of this work is to demonstrate for the first time that elemental analysis and Fourier transform infrared spectroscopy microscopic examination of breast tissue sections can be merged into one dataset to provide a single set of markers based on both organic molecules and inorganic trace elements. For illustrating the method, 6 mammary tissue sections were used. Fourier transform infrared (FTIR) spectroscopy images reported a fingerprint of the organic molecules present in the tissue section and laser ablation elemental analysis (LA-ICP-MS) images brought inorganic element profiles. The 6 tissue sections provided 31 10 6 and 150,000 spectra for FTIR and LA-ICP-MS spectra respectively. The results bring the proof of concept that breast tissue can be analyzed simultaneously by FTIR spectroscopy and laser ablation elemental analysis (LA-ICP-MS) to provide in both case reasonably high resolution images. We show how to bring the images obtained by the two methods to a same spatial resolution and how to use image registration to analyze the data originating from both techniques as one block of data. We finally demonstrates the elemental analysis is orthogonal to all FTIR markers as no significant correlation is found between FTIR and LA-ICP-MS data. Combining FTIR and LA-ICP-MS imaging becomes possible, providing two orthogonal methods which can bring an unprecedented diversity of information on the tissue. This opens a new avenue of tissue section analyses providing unprecedented diagnostic potential.

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Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis

Cited by 6 publications

References 36 publications

PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells

PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells

ZNF350 promoter methylation accelerates colon cancer cell migration

An Innovative Platform Merging Elemental Analysis and Ftir Imaging for Breast Tissue Analysis

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