Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients

Kountouras, Jannis; Boziki, Marina; Gavalas, Emmanuel; Zavos, Christos; Deretzi, Georgia; Chatzigeorgiou, Stavros; Katsinelos, Panagiotis; Grigoriadis, Nikolaos; Giartza-Taxidou, Evangelia; Venizelos, Ioannis

doi:10.1097/wnn.0b013e3181df3034

Cited by 98 publications

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“…This finding further reinforced the possible causal link between H. pylori and AD [12]. In another intervention study with survival as the end point, the group with successful H. pylori eradication compared to those with unsuccessful eradication had significantly lower mortality risk (HR [95% CI] = 0.29 [0.11–0.73]), after adjusting for baseline age and Mini–Mental State Examination score [13]. Looking further into biomarkers of AD, among 53 AD patients, H. pylori infection was associated with lower Mini–Mental State Examination score (P = .024), higher cerebrospinal fluid phosphorylated Tau protein(181) (P = .014), and tau (P = .021) levels [16].…”

Section: Discussionmentioning

confidence: 77%

Helicobacter pylori seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

Beydoun

Elbejjani

et al. 2018

Alzheimer's & Dementia

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Introduction: Infectious agents were recently implicated in Alzheimer’s disease (AD) and etiology of other dementias, notably Helicobacter pylori. Methods: We tested associations of H. pylori seropositivity with incident all-cause and AD dementia and with AD-related mortality among US adults in a retrospective cohort study. Data from the National Health and Nutrition Surveys III, phase 1 (1988–1991) and 1999–2000 linked with Medicare and National Death Index registries, were used (baseline age ≥45 y, follow-up to 2013, Npooled = 5927). Results: A positive association between H. pylori seropositivity and AD mortality was found in men (hazard ratioadj, pooled = 4.33, 95% confidence interval: 1.51–12.41, P =.006), which was replicated for incident AD and all-cause dementia, with hazard ratioadj, pooled = 1.45 (95% confidence interval: 1.03–2.04, P = .035) and hazard ratioadj, III = 1.44 (95% confidence interval: 1.05–1.98, P = .022), respectively. These associations were also positive among higher socioeconomic status groups. Discussion: In sum, H. pylori seropositivity’s direct association with AD mortality, all-cause dementia, and AD dementia was restricted to men and to higher socioeconomic status groups. Published by Elsevier Inc. on behalf of the Alzheimer’s Association.

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Section: Discussionmentioning

confidence: 77%

Helicobacter pylori seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

Beydoun

Elbejjani

et al. 2018

Alzheimer's & Dementia

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“…Таким образом, H. pylori может играть непосредственную роль в развитии ряда дегенеративных заболеваний ЦНС, хотя доказательная база этих находок пока ограничена [7,9]. В небольших исследованиях у пациентов с бо-лезнью Альцгеймера показан положительный эффект эрадика-ции H. pylori, связанный с улучшением когнитивного статуса больных и повышением выживаемости [32,33]. Однако в этом направлении, безусловно, нужны более крупные исследования.…”

Section: терапевтический архив 8 2015unclassified

Helicobacter pylori infection and extragastroduodenal diseases

Маев¹,

Andreev²,

Kucheryavyi³

2015

Ter. arkh.

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АннотацияНа настоящее время достоверно определена клиническая значимость инфекции Helicobacter pylori в рамках развития целого ряда заболеваний гастродуоденальной зоны, включая хронический гастрит, язвенную болезнь желудка и двенад-цатиперстной кишки, MALT-лимфому, а также аденокарциному желудка. В консенсусе Маастрихт IV (2010 г.), определя-ющем международные стандарты диагностики и лечения инфекции H. pylori, экспертный совет постановил, что имеются доказательства возможной ассоциации инфекции H. pylori с развитием ряда экстрагастродуоденальных заболеваний (ЭГДЗ), представленных железодефицитной анемией неуточненной этиологии, идиопатической тромбоцитопенической пурпурой и дефицита витамина В 12 . При этих заболеваниях рекомендовано проведение диагностики инфекции H. pylori и при положительных результатах тестирования -эрадикация микроорганизма. За последнее время проведено большое количество исследований, посвященных изучению связи инфекции H. pylori и с другими ЭГДЗ. В настоящей статье приво-дится обзор теоретических и эпидемиологических данных ассоциации H. pylori с заболеваниями органов сердечно-сосу-дистой системы (атеросклероз, инфаркт миокарда), центральной нервной системы (болезнь Альцгеймера, болезнь Пар-кинсона), поджелудочной железы (аутоиммунный панкреатит, рак поджелудочной железы), онкологическими (аденомы толстой кишки, колоректальный рак, гепатоцеллюлярная карцинома), дерматологическими (хроническая спонтанная кра-пивница, псориаз) а также другими ЭГДЗ. В обзоре освещается потенциальная защитная роль H. pylori при заболеваниях с атопическим элементом генеза и осложненном течении гастроэзофагеальной рефлюксной болезни (пищевод Барретта, аденокарцинома пищевода). At present, the clinical significance of Helicobacter pylori infection has been validly determined within the development of a diversity of gastroduodenal diseases, including chronic gastritis, gastroduodenal ulcer, MALT lymphoma, and gastric adenocarcinoma. The Expert Council's Maastricht IV consensus (2010) determining international standards for the diagnosis and treatment of H. pylori infection is that there is evidence that the latter may be associated with the development of a number of extragastroduodenal diseases (EGDDs) presented by iron-deficiency anemia of unspecified etiology, idiopathic thrombocytopenic purpura, and vitamin B 12 deficiency. In these diseases, it is recommended that infection with H. pylori be diagnosed and, if the test is positive, this microorganism be eradicated. A large number of investigations have been recently conducted to examine the association of H. pylori infection with other EGDDs. This paper reviews theoretical and epidemiological data on the association of H. pylori with diseases of the cardiovascular (atherosclerosis, myocardial infarction) and central nervous (Alzheimer's disease, Parkinson's disease) systems, pancreas (autoimmune pancreatitis, pancreatic cancer), oncological (colonic adenomas, colorectal cancer, hepatocellular carcinoma), dermatological (chronic spontaneous urticaria), and ot...

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“…Although minimal hepatic encephalopathy plays a key role in such dysfunction, other factors, such as etiology of cirrhosis, comorbidities, or psychoactive treatments, can also be implicated. [1][2][3] Multiple factors are also involved in the risk of falling. 4 1284 CORRESPONDENCE HEPATOLOGY, March 2013…”

Section: Replymentioning

confidence: 99%

“…[2][3][4] In this respect, we reported that Hp-I is frequently detected in neurodegenerative diseases including CD and Alzheimer's disease (AD) and Hp eradication may positively influence AD manifestations at 2-and 5-year clinical endpoints, 2 thereby supporting a role for this common infection in the pathobiology of the disease. Others also found that AD patients infected by Hp tended to be more cognitively impaired, and patients with dementia have a higher risk of falls and fractures 3 ; Hp-I may also be responsible for osteoporosis.…”

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confidence: 99%

Helicobacter pylori induced cognitive dysfunction might be associated with falls and fractures in cirrhosis

et al. 2013

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Helicobacter pylori Induced Cognitive Dysfunction Might Be Associated With Falls and Fractures in CirrhosisTo the Editor:In their prospective series, Soriano et al. 1 concluded that cognitive dysfunction (CD) is a factor associated with falls in patients with cirrhosis, and further studies are warranted to address the mechanisms implicated in this predisposition and to design preventive strategies.Apart from CD causes that can be the result of multiple issues, including the etiology of cirrhosis, mentioned by the authors, 1 Helicobacter pylori infection (Hp-I) appears to be a common denominator associated with CD-related falls and fractures and liver cirrhosis. [2][3][4] In this respect, we reported that Hp-I is frequently detected in neurodegenerative diseases including CD and Alzheimer's disease (AD) and Hp eradication may positively influence AD manifestations at 2-and 5-year clinical endpoints, 2 thereby supporting a role for this common infection in the pathobiology of the disease. Others also found that AD patients infected by Hp tended to be more cognitively impaired, and patients with dementia have a higher risk of falls and fractures 3 ; Hp-I may also be responsible for osteoporosis. Moreover, hepatitis B (HBV) and C (HCV) are among the commonest causes of liver cirrhosis worldwide 4,5 and Hp-I is strongly associated with HBV-and HCVrelated cirrhosis in Europe (Italy); Hp-I is more common in cirrhosis patients with hepatic encephalopathy (HE) than in those without, 5 and HE is not a fully reversible condition.Summarizing the aforementioned data, Hp may be involved in the pathophysiology of cirrhosis-related CD by several mechanisms, 4 such as the release of proinflammatory and vasoactive substances, involved through blood-brain barrier (BBB) disruption, in a number of vascular disorders including AD, which can lead to long-term neurologic deficits; promoting platelet-leukocyte aggregation proposed to play pathophysiologic roles in AD and liver fibrosis; producing reactive oxygen metabolites involved in the AD pathophysiology and complications of cirrhosis; or influencing the apoptotic process, an important form of cell death in AD and cirrhosis. Finally, activated monocytes (possibly infected with Hp due to defective autophagy resulting in Hp replication in autophagic vesicles) might also enter the brain due to BBB disruption contributing to cirrhosis-related CD development associated with falls and fractures. 3

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Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients

Abstract: Hp eradication regimen in AD patients is associated with a higher 5-year survival rate.

Cited by 98 publications

References 0 publications

Helicobacter pylori seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

Helicobacter pylori seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

Helicobacter pylori infection and extragastroduodenal diseases

Helicobacter pylori induced cognitive dysfunction might be associated with falls and fractures in cirrhosis

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