Five-Year Subjective and Objective Results of Laparoscopic and Conventional Nissen Fundoplication

Draaisma, Werner A.; Jong, Hilda G. Rijnhart-de; Broeders, I. A. M. J.; Smout, A. J. P. M.; Furnée, Edgar J.B.; Gooszen, Hein G.

doi:10.1097/01.sla.0000217667.55939.64

Cited by 156 publications

(91 citation statements)

References 43 publications

(35 reference statements)

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“…13 In addition intraluminal impedance monitoring enables quantification of both acid and weakly acidic reflux and proximal reflux events. 14 In this study we used high resolution esophageal manometry combined with pH and impedance monitoring to evaluate late (14-year) objective outcomes in a subset of patients enrolled in a prospective randomized trial of anterior 180˚ partial vs. Nissen fundoplication.…”

Section: Introductionmentioning

confidence: 99%

Objective Outcomes 14 Years After Laparoscopic Anterior 180-Degree Partial Versus Nissen Fundoplication

Broeders

Watson

et al. 2013

Annals of Surgery

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Please note that any alterations made during the publishing process may not appear in this version. Objective Outcomes 14 Years after Laparoscopic Anterior 180˚ Partial versus Nissen FundoplicationResults from a Randomized Trial Results: 18 patients (8 anterior, 10 Nissen) underwent objective testing and had a symptom profile similar to those who did not (n=59) have testing. Total esophageal acid exposure time and the total number of acid and weakly acidic reflux episodes per 24 h were higher after anterior fundoplication than after Nissen fundoplication. Proximal, mid-esophageal and distal reflux were proportionately increased after anterior 180˚ fundoplication. The number of liquid and mixed reflux episodes were also higher after anterior fundoplication, which was accompanied by higher clinical heartburn scores. There were no differences in gas reflux, gastric belches and supragastric belches, which is in line with the observation that gasrelated symptoms were similar for both groups. Mean LES resting and relaxation nadir pressure were lower after anterior fundoplication, which was reflected by lower dysphagia scores. Patient satisfaction is similar after both procedures.Conclusions: At 14 years after randomization, this study demonstrated that acid, weakly acidic, liquid and mixed reflux episodes are more common after anterior 180˚ fundoplication compared to Nissen fundoplication. On the other hand, gas reflux and gastric belching and patient satisfaction are similar for both procedures. Mean LES resting and relaxation nadir pressure are lower after anterior fundoplication. Overall these findings suggests less effective 4Archived at Flinders University: dspace.flinders.edu.au 5 reflux control after anterior 180˚ partial fundoplication, offset by less dysphagia, leading to a clinical outcome which is equivalent to Nissen fundoplication at late follow-up.

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Section: Introductionmentioning

confidence: 99%

Objective Outcomes 14 Years After Laparoscopic Anterior 180-Degree Partial Versus Nissen Fundoplication

Broeders

Watson

et al. 2013

Annals of Surgery

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“…Nissen fundoplication restores the third function and provides excellent reflux control. [1][2][3] However, it delivers a supracompetent valve which can impair the first two functions. Three meta-analyses have demonstrated that Nissen fundoplication is followed by a significant incidence of troublesome postfundoplication side effects, including troublesome postoperative dysphagia and gas related problems.…”

Section: Introductionmentioning

confidence: 99%

Five-Year Outcome After Laparoscopic Anterior Partial Versus Nissen Fundoplication

et al. 2012

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Mini-AbstractAnalysis of original data of 5-year outcomes from 461 patients enrolled in 4 randomized trials demonstrates that laparoscopic anterior 180˚ partial fundoplication is an effective treatment for gastroesophageal reflux, but with less side effects compared with Nissen fundoplication, although reflux control following anterior 90˚ partial fundoplication appears less effective than after Nissen fundoplication.

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“…It is effective in reducing gastro-oesophageal reflux, both acid and nonacid. 95 The mechanisms through which fundoplication reduces reflux are complex and incompletely understood. Currently, it is believed that three mechanisms may play a role.…”

mentioning

confidence: 99%

Review article: the clinical relevance of transient lower oesophageal sphincter relaxations in gastro-oesophageal reflux disease

Kessing

Conchillo

Bredenoord

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

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Five-Year Subjective and Objective Results of Laparoscopic and Conventional Nissen Fundoplication

Cited by 156 publications

References 43 publications

Objective Outcomes 14 Years After Laparoscopic Anterior 180-Degree Partial Versus Nissen Fundoplication

Objective Outcomes 14 Years After Laparoscopic Anterior 180-Degree Partial Versus Nissen Fundoplication

Five-Year Outcome After Laparoscopic Anterior Partial Versus Nissen Fundoplication

Review article: the clinical relevance of transient lower oesophageal sphincter relaxations in gastro-oesophageal reflux disease

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