Five-Year Results of a Randomized, Controlled Trial of Collagenase Treatment Compared With Needle Fasciotomy for Dupuytren Contracture

Byström, Martin; Sörensen, Allan Ibsen; Samuelsson, Kristian; Fridén, Jan; Strömberg, Joakim

doi:10.1016/j.jhsa.2021.11.019

Cited by 13 publications

(16 citation statements)

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“…In another recently published study, roughly half of the patients still had a PED of less than 5 degrees in the MCP joint 5 years later. 19 Contracture recurrence rates in PIP joints were 21% in the PNF group and 22% in the CCH group, whereas in MCP joints, we observed no recurrence in PNF and 20% in CCH. In this study, we used the cutoff point of 20 degrees or more in PED for every treated joint after long-term follow-up compared to the result at 3 weeks.…”

Section: Discussionmentioning

confidence: 48%

“…In another recently published study, roughly half of the patients still had a PED of less than 5 degrees in the MCP joint 5 years later. 19 …”

Section: Discussionmentioning

confidence: 99%

“…The same research group recently described that the recurrence rate in the MCP joint contracture was not different between the two treatment groups 5 years after the intervention. 19 Unfortunately, it is difficult to compare the studies as the definition of contracture recurrence varies in the cutoff point used, the timing of baseline measurement‚ and whether the extension deficits were measured actively or passively. 16 , 20 , 22 We suggest to use the standardized criteria of the consensus-based definition of contracture recurrence in DD: “more than 20 degrees of contracture recurrence in any treated joint at 1-year posttreatment compared to 6 weeks posttreatment.” 23 …”

Section: Discussionmentioning

confidence: 99%

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Dupuytren Disease: A Retrospective Cohort Study Comparing Collagenase Injection and Percutaneous Needle Fasciotomy

Mehdiyev

Maffei

Müller

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Background: Collagenase Clostridium histolyticum (CCH) injection and percutaneous needle fasciotomy (PNF) are minimally invasive procedures aiming to relieve Dupuytren disease (DD) by disrupting the cord and restoring the normal functionality of the hand. The purpose of this study is to compare the outcomes and recurrence rates for treatment of DD in the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints with either collagenase or percutaneous needle at 3-year follow-up. Moreover, we aim to determine the role of these therapeutic modalities and their impact on hand functionality and quality of life. Methods: In this retrospective analysis, we compare treatment outcomes in 35 patients, of whom 22 were treated with PNF and 13 with CCH injection. Results: The mean outcome in contracture degrees at 3-year follow-up was 9 degrees for MCP joints for both treatment groups, 34 degrees for PNF, and 28 degrees for CCH for PIP joints. There was no statistical significance between the treatment groups in MCP joints (P = 0.786) or in PIP joints (P = 0.474). Contracture recurrences were similar in PIP joints of both groups and greater in MCP joints in the CCH group compared to PNF. The Disabilities of the Arm, Shoulder, and Hand and the Unité Rhumatologique des Affections de la Main scores showed a reduction in impairment in both groups without significant differences between the two groups. Conclusions: The results of this study show that PNF appears to be as effective and minimally invasive as CCH injection, but at significantly lower cost. Considering these factors, the authors prefer and recommend the use of PNF over CCH.

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Section: Discussionmentioning

confidence: 48%

“…In another recently published study, roughly half of the patients still had a PED of less than 5 degrees in the MCP joint 5 years later. 19 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dupuytren Disease: A Retrospective Cohort Study Comparing Collagenase Injection and Percutaneous Needle Fasciotomy

Mehdiyev

Maffei

Müller

et al. 2022

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

“…Authors from Gothenburg (Sweden) reported their five-year results of a randomized controlled trial comparing needle fasciotomy and CCH. 5 This was a single-centre, prospective trial recruiting adult patients with a palpable Dupuytren's cord, and extension defi- between the groups. This study demonstrates the relative success of these minimally invasive techniques.…”

Section: Five-year Results Collagenase Treatment Versus Needle Fascio...mentioning

confidence: 99%

“…Authors from Gothenburg (Sweden) reported their five-year results of a randomized controlled trial comparing needle fasciotomy and CCH. 5 This was a single-centre, prospective trial recruiting adult patients with a palpable Dupuytren’s cord, and extension deficit of ≥ 20° at the metacarpophalangeal joint of a single finger. Power calculations indicated a target recruitment of 78 patients in each group.…”

Section: Five-year Results Collagenase Treatment Versus Needle Fascio...mentioning

confidence: 99%

Wrist & Hand

2022

Bone & Joint 360

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Outcomes Following Repeat Collagenase Treatment of Dupuytren Contracture

Legato

Gill

Coutelle

et al. 2023

The Journal of Hand Surgery

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Five-Year Results of a Randomized, Controlled Trial of Collagenase Treatment Compared With Needle Fasciotomy for Dupuytren Contracture

Cited by 13 publications

References 30 publications

Dupuytren Disease: A Retrospective Cohort Study Comparing Collagenase Injection and Percutaneous Needle Fasciotomy

Dupuytren Disease: A Retrospective Cohort Study Comparing Collagenase Injection and Percutaneous Needle Fasciotomy

Wrist & Hand

Outcomes Following Repeat Collagenase Treatment of Dupuytren Contracture

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