Five-Year Prognosis after Radical Prostatectomy in a Patient with Localized Prostate Cancer and Incidental Non-Hodgkin’s Lymphoma

Abstract

We present a white male patient with an initial prostate-specific antigen level of 69 ng/ml, referred for urological evaluation. He was found to be free of prostatitis but diagnosed for prostate adenocarcinoma without any indications of metastatic disease. Lymphadenectomy then revealed lymphadenopathy of low-grade non-Hodgkin’s lymphoma. Five-year follow-up after radical retropubic prostatectomy (RRP) showed no evidence of metastatic or local prostate cancer recurrence. In addition, no radiation or chemotherapy was required for his lymphoma. Although RRP is a viable option in this unique case, the outcome thus far suggests that it should be considered a primary therapeutic modality.

Incidental advanced-stage Hodgkin lymphoma diagnosed at the time of radical prostatectomy for prostatic cancer: a case report and review of literature

“…)3 (1.2%)Lymphoma NOSN.A.Terris et al 1997 [7]1092 (all patients)13 (1.2%)3 HLPelvic and abdominal external beam irradiation1 HCLAggressive tp NOS1 CLLNo tp6 SLLNo tpEisenberger et al 1999 [8]4319 (all patients)10 (0.2%)8 Lymphocytic lymphomaSingle-agent CT2 FLN.AWinstanley et al 2002 [9]1001 (854)15 (1.8%)2 SLL/CLLN.A.3 neoplastic (0.003%)1 FLN.A.12 Non-neoplastic findings 1 N.A.Weir et al 2003 [10]6143 (all patients)18 (0.3%)18 SLL/CLLN.A.He et al 2007 [11]1500 (1150)13 (1.13%)9 SLL/CLLN.A.3 MZLN.A.1 MCLAggressive CT NOSChu et al 2005 [12]4831 3 (N.A. )29 (0.6%)18 incidental casesN.A.13 SLL/CLLN.A.3 MZL1 MCL11 concurrent known lymphoma 2 4 SLL/CLL4 FL2 MCL1 DLBCL Isolated case reports Encountered Hematolymphoid malignancy Treatment required for hematologic malignancy Carson H et al 1996 [13]1 SLL/CLLN.AMydlo et al 2001 [14]1 lymphoma NOSN.ADrinis et al 2009 [15]1 SLL/CLLNo tpAbbreviations used: NOS not otherwise specified, tp therapy, N.A . not available, CT chemotherapy, HL Hodgkin lymphom, HCL hairy cell leukemia, CLL chronic lymphocytic leukemia, SLL small lymphocytic lymphoma, MZL marginal zone lymphoma, MCL mantle cell lymphoma.…”

“…have raised the intriguing possibility that lymphomas could potentially protect against PCa progression. According to these authors, such protection could result from the over-expression of circulating transmembrane molecule CD44 in leukemia and lymphoma patients [15]. Some experimental studies support a tumor suppressor function of CD44 in lymphomas; silencing of CD44 expression may facilitate lymphoma genesis [31].…”

Metachronous non-Hodgkin's lymphoma in a patient with localized prostate cancer

“…Synchronous tumors with prostate adenocarcinoma have been reported in the literature [1][2][3][4][5][6][7]. The coincidental discovery of lymphoma during pelvic lymphadenectomy for localized prostate cancer has been estimated to be between 0.2% [2] and 1.2% [6,8].…”

“…In the English literature, synchronous lymphoma in patients with prostate cancer has been reported [1][2][3][4][5][6][7]. A detailed search did not reveal metachronous lymphoma in those patients.…”

Nonepithelial Tumors and Tumor-Like Lesions of the Prostate Gland

“…207 Cases of incidental prostatic lymphoma in association with prostate carcinoma have been reported. 187,208,207 In a review of 4319 prostatectomies at Johns Hopkins Hospital, only 10 (0.2%) cases of incidental prostate lymphoma were identified. 209 In most of these cases 208,209 the lymphoma was low grade, and the authors recommended that prostatectomy, as a treatment of carcinoma, should not be denied.…”