Five-year follow-up study of the fat clearance technique in colorectal carcinoma

Abstract

The fat clearance technique is a useful aid to improving the accuracy of the Dukes classification and has prognostic significance. It should be used in specimens of colorectal carcinoma, which on initial examination appear to be Dukes B cases.

Is there a minimum number of lymph nodes that should be histologically assessed for a reliable nodal staging of T3N0M0 colorectal carcinomas?

“…The facts that a minority of the ''only metastatic'' nodes are relatively far from the tumor [23,24], and that small metastatic lymph nodes can be identified only with the help of fatclearing agents [25][26][27], suggest that the locations and sizes (although important features of lymph nodes that determine their likelihood of being metastatic) are not sufficiently discriminative to distinguish between positive and negative lymph nodes.…”

Accuracy of the Extent of Bladder Cancer Nodal Metastases Found at Pelvic Lymphadenectomy at the Time of Cystectomy: Relation to Primary Tumor Stage

“…Despite a given LND template, a variable number of nodes may be retrieved and a variable number of positive nodes may be identified by [3,7,8,14,19] versus an average of 20 nodes with modified pelvic LND for prostate cancer [20] . This variability may be due to individual variation depending on age, differing yields with various templates and differing numbers of nodes identified by the pathologist depending on whether the nodal packets are submitted en bloc or individually [8] and whether fat-clearing solutions are used [9][10][11] . Thus, in our model, the actual number of pelvic nodes 'N' that can be retrieved and identified by the pathologist is unknown and is taken to be 30 representing the 95% upper bound on the nodal count histogram.…”

“…There is great variation in the extent [2,6,7] and surgical technique of LND [8] , as well as variation in the technique of histologic examination [9][10][11] . Individually submitted packets have yielded a greater number of nodes compared to en-bloc specimens, with mean yields of 36.5 and 22.6 nodes, respectively [8] .…”

Diferença entre hospitais privado e universitário na taxa de linfonodos de peça cirúrgica de câncer colorretal: o papel do patologista

“…Este fato é corroborado pelos estudos desenvolvidos por Tekkis et al 6 , Scott et al 11 , Cserni et al 12 e Rodrigues-Bigas et al 13 que afirmam a necessidade de padronização da dissecção linfonodal pelo uso de solução clareadora de linfonodos. Esses estudos relataram que a maioria dos focos metastáticos são observados em linfonodos menores que 5 mm.…”