Five-year follow-up study of cases suggestive of acute myocarditis

Bengtsson, Elias; Lamberger, Berndt

doi:10.1016/0002-8703(66)90158-x

Cited by 52 publications

(13 citation statements)

References 31 publications

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“…Several studies have documented persistent and progressive symptoms, along with chest X-ray and electrocardiogram abnormalities, following acute viral myocarditis (predominately coxsackieviruses) (8,50,120,131,132). Miklozek et al followed 16 patients diagnosed as having viral myocarditis by using serial cardiac function tests.…”

Section: Clinical Diseasementioning

confidence: 99%

Clinical and experimental aspects of viral myocarditis

et al. 1989

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Picornaviruses are frequently implicated as the etiological agents of acute myocarditis. This association is based historically on serological evidence of rising antibody titers to specific pathogens and more recently on identification of viral genomic material in endocardial biopsy specimens through in situ hybridization. Only rarely is infectious virus isolated from either the patient or the heart during periods of maximum myocardial inflammation and injury. Thus, despite a probable viral etiology, much interest centers on the role of the immune system in cardiac damage and the likelihood that the infection triggers an autoimmune response to heart-specific antigens. Heart-reactive antibodies and T cells are found in most myocarditis patients, and immunosuppressive therapy has proven beneficial in many, though not all, cases. Furthermore, murine models of coxsackievirus group B type 3-induced myocarditis also demonstrate that virus infection initiates autoimmunity and that these autoimmune effectors are predominately responsible for tissue injury. How virus-host interactions overcome presumed self-tolerance to heart antigens is discussed, and evidence supporting various theories of virus-initiated autoimmunity and disease pathogenesis are delineated.

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Section: Clinical Diseasementioning

confidence: 99%

Clinical and experimental aspects of viral myocarditis

et al. 1989

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“…However, several investigators have reported the long-term incidence of DCM following an episode of acute viral myocarditis based on clinical presentation (Table 1) [2,3,8,10,13,22,24,28]. Of these 400 patients who had been followed for as long as 7 years, 50 (12%) were found to have DCM.…”

Section: Myocarditis As a Precursor Of Dcm: Clinical Evidencementioning

confidence: 99%

Therapeutic implications of immune mechanisms in myocarditis

O’Connell

Mason

1989

Springer Semin Immunopathol

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“…A series of 90 such patients, who had been healthy before the onset, and in whom the diagnosis of acute myocarditis had been carefully considered and established, were followed up 5 years later [Bengtsson and Lamberger, 1966]. Approximately 25% re ported persistence of subjective symptoms; almost all had pre cordial pain, a feeling of oppression or arrhythmia; fatigue was the sole complaint in only two cases.…”

Section: Prognosismentioning

confidence: 99%

Myocarditis and Cardiomyopathy

Bengtsson¹

1968

Cardiology

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Five-year follow-up study of cases suggestive of acute myocarditis

Cited by 52 publications

References 31 publications

Clinical and experimental aspects of viral myocarditis

Clinical and experimental aspects of viral myocarditis

Therapeutic implications of immune mechanisms in myocarditis

Myocarditis and Cardiomyopathy

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