Five‐year follow up of selective laser trabeculoplasty in Chinese eyes

Lai, Jimmy S. M.; Chua, John K. H.; Tham, Clement C.; Lam, Dennis S C

doi:10.1111/j.1442-9071.2004.00839.x

Cited by 140 publications

(107 citation statements)

References 19 publications

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“…There was a trend toward more treatment steps necessary for adequate IOP control in the medication arm with 27% requiring additional drops compared to 11% in the SLT group receiving additional laser [8]. Other prospective studies have been done which corroborate with our findings [86][87][88].…”

Section: Selective Laser Trabeculoplasty As Initial Treatmentsupporting

confidence: 82%

Laser Trabeculoplasty and Aqueous Dynamics

Lee¹,

Rahmatnejad²,

Waisbourd³

et al. 2016

Glaucoma - Intraocular Pressure and Aqueous Dynamics

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For the past four decades, laser trabeculoplasty has been a staple in the treatment armamentarium against glaucoma. Although the exact mechanism of laser trabeculoplasty has not been fully elucidated, its clinical utility in lowering intraocular pressure has been well established. Aqueous dynamic studies uniformly reveal an increase in aqueous outflow facility at the trabecular meshwork. Accumulating evidence suggests that the mechanism is the result of complex cellular and biochemical processes. Histopathological studies of the trabecular meshwork tissue after argon laser suggest an additional mechanical role. The traditional treatment algorithm for glaucoma placed laser trabeculoplasty as an intermediary between medical therapy and incisional surgery. However, because of the safety profile of selective laser trabeculoplasty, recent studies have challenged this treatment paradigm. One such study was a multicenter trial headed by our department that compared laser trabeculoplasty and medical therapy as initial treatment for glaucoma. We showed a similar efficacy between the two modalities, reinforcing the possibility of using laser as the initial treatment in the right clinical setting.

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Section: Selective Laser Trabeculoplasty As Initial Treatmentsupporting

confidence: 82%

Laser Trabeculoplasty and Aqueous Dynamics

Lee¹,

Rahmatnejad²,

Waisbourd³

et al. 2016

Glaucoma - Intraocular Pressure and Aqueous Dynamics

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show abstract

“…In a study by Lai et al, 11 17.2% of the patients with POAG or ocular hypertension required trabeculectomy after SLT despite maximal medications. The observations in the PG eyes, including more complications, decreasing IOP-lowering effect after 6 months, and more need for further surgical interventions, may indicate that SLT is less efficient in PG eyes compared with PEX and POAG eyes.…”

Section: Discussionmentioning

confidence: 98%

Selective Laser Trabeculoplasty in the Treatment of Open-angle Glaucoma

Koucheki

Hashemi

2012

Journal of Glaucoma

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“…All such reductions were statistically significantly lower than baseline. Although the effect of SLT may be greatest immediately after treatment 15,16 because of the increase in porosity of the trabecular meshwork from the upregulation of metalloproteinases, cytokines, and macrophages, 17 the lower IOP on day 1 post SLT may also be contributed in part to a falsely low IOP reading resulting from alterations in corneal hysteresis from the subclinical corneal edema. It has been demonstrated that corneal edema after phacoemulsification has been associated with a relatively lower IOP by Goldmann applanation tonometry because of the reduction of corneal hysteresis and alterations of the stromal lamellar architecture.…”

Section: Discussionmentioning

confidence: 99%

Corneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma

Lee

Chan

Chang

et al. 2013

Eye

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Purpose To investigate the changes in endothelial cell count, central corneal thickness (CCT), and refractive error after a session of selective laser trabeculoplasty (SLT) for open angle glaucoma (OAG). Methods This prospective cohort study recruited 111 eyes of 66 consecutive subjects with OAG. Subjects received SLT to 3601 of the trabecular meshwork. Endothelial cell count, CCT, and spherical equivalent were measured at baseline before SLT as well as at 1 week and 1 month post SLT. A repeated measure nested ANOVA with Tukey's multiple comparison test was performed to compare the outcome measures before and after SLT. Results In 111 eyes of 66 subjects, the mean number of laser applications per treatment was 166.9 ± 41.4 with a mean energy level of 1.0 ± 0.07 mJ. The mean endothelial cell count decreased significantly from 2465.0±334.0 cells/mm 2 at baseline to 2355.0±387.0 cells/mm 2 at 1 week (P ¼ 0.0004) but increased to baseline levels at 1 month post SLT (2424.0 ± 379.4 cells/mm 2 , P ¼ 0.3). The CCT, which decreased from a baseline of 549.4 ± 37.6 to 543.9 ± 40.2 mm at 1 week post SLT (P ¼ 0.02), also returned to the baseline level by 1 month (P ¼ 0.2). The spherical equivalent was static from baseline. A positive correlation was found between total laser energy and CCT at 1 month post treatment (r ¼ 0.3, P ¼ 0.005). Conclusion The transient reductions in endothelial cell count and CCT following SLT returned to baseline levels 1 month after the procedure. Patients undergoing SLT should be aware of the risk of potential corneal changes.

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Five‐year follow up of selective laser trabeculoplasty in Chinese eyes

Abstract: With fewer medications, SLT gives similar intraocular pressure reduction to medical therapy alone in Chinese patients with primary open-angle glaucoma or ocular hypertension.

Cited by 140 publications

References 19 publications

Laser Trabeculoplasty and Aqueous Dynamics

Laser Trabeculoplasty and Aqueous Dynamics

Selective Laser Trabeculoplasty in the Treatment of Open-angle Glaucoma

Corneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma

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