Five-year follow up of patients with cervical intra-epithelial neoplasia in the cone margins after conization

Vedel, Pernille; Jakobsen, Henrik; Kryger-Baggesen, Niels; Rank, Fritz; Bostofte, Erik

doi:10.1016/0028-2243(93)90167-b

Cited by 28 publications

(17 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Involved margins after coniza- tion are known to be one of the risk factors for persistence/recurrence of CIN in HIV-negative women, with incidence rate of recurrence ranging from 8.7% to 40% in patients with incomplete resection. [25][26][27][28][29] We only included in the review recurrence rates estimated from populations with known free resection margins to avoid including cases with persistent disease. Nevertheless, the recurrence rates in HIV-infected patients were even higher than those in HIV-negative patients with involved margins.…”

Section: Discussionmentioning

confidence: 99%

The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literature

et al. 2006

View full text Add to dashboard Cite

The objective of this study was to assess the available evidence on the outcome of cervical intraepithelial neoplasia (CIN) in HIV-positive women after conization. We performed a literature search of Medline and Cochrane libraries to locate published articles reporting about the rate of recurrence of CIN after excisional treatment in patients with negative surgical margins. Out of 15 articles, five studies reported recurrence rate of CIN in margin negative patients. The recurrence rate of CIN after conization in HIV-infected women ranges from 20% to 75%. No conclusions can be drawn about the impact of CD4 cell counts on the recurrence rate. Available evidence suggests that standard excisional treatments for CIN are associated with high rates of recurrence in HIV-positive women. Despite the fact that the evidence is limited because of the few number of eligible studies, this issue should be considered in the management of HIV-positive patient with CIN.

show abstract

Section: Discussionmentioning

confidence: 99%

The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literature

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Worse than LSIL cases are particularly likely to develop recurrence. Recurrence of CIN 3 was identified in 6 cases (4.2% of all patients); this recurrence rate was somewhat higher compared with the reported margin-negative cases (14,15). CIN 3 recurrent cases were observed within 12 months and after 42 months following conization.…”

Section: Cytological Findings After Treatment -----------------------mentioning

confidence: 68%

Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade?3 neoplasia: A retrospective single‑center cohort study

et al. 2017

View full text Add to dashboard Cite

Abstract. The aim of the present study was to evaluate the clinical significance of atypical squamous cells of undetermined significance (ASC-US) following cervical conization for cervical intraepithelial neoplasia (CIN) grade 3. This study was a retrospective cohort analysis. The medical records of women treated with conization for CIN 2-3 were reviewed and 142 patients with CIN 3 who had been diagnosed using the conization specimens were selected. The mean follow-up period after conization was 41.8 months. Cytological abnormalities after conization were observed in 19.0% of the patients and consisted of ASC-US (13.4%) and worse than low-grade squamous intraepithelial lesion (LSIL; 5.6%). Recurrence was defined as a diagnosis worse than CIN 2, and the recurrence rate was 29.6% among patients with abnormal cytology. The recurrence rate was 15.7% in the ASC-US group and 71.4% in the worse than LSIL group. There was no significant difference in the time of initial identification of abnormal cytology after treatment between the worse than LSIL and the ASC-US groups (P= 0.054). However, the ASC-US group had a significantly better cumulative recurrence-free rate compared with the worse than LSIL group (P<0.05). Women with ASC-US following treatment for CIN appear to be at a relatively high risk. Regarding the risk stratification of women following treatment for CIN, if surveillance cytology shows ASC-US, immediate colposcopy is recommended, along with long-term follow-up.

show abstract

“…C Acta Obstet Gynecol Scand 78 (1999) cies 9-30% (4,11,12,(21)(22)(23)(24). We also found the endocervical margin involved markedly more often than the vaginal, again in accordance with most other reports (12,22).…”

Section: Discussionmentioning

confidence: 99%

“…Invasive disease is seldom observed after laser conization (10). The presence of CIN on follow-up has variously been referred to as residual or recurrent disease (10)(11)(12).…”

mentioning

confidence: 99%

Laser conization of cervical intraepithelial neoplasia grade 3, Free resection margins indicative of lesion‐free survival

Bertelsen¹,

Tande

Sandvei

et al. 1999

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Five-year follow up of patients with cervical intra-epithelial neoplasia in the cone margins after conization

Cited by 28 publications

References 12 publications

The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literature

The recurrence of cervical intraepithelial neoplasia in HIV-positive women: a review of the literature

Clinical significance of atypical squamous cells of undetermined significance after treatment for cervical intraepithelial grade?3 neoplasia: A retrospective single‑center cohort study

Laser conization of cervical intraepithelial neoplasia grade 3, Free resection margins indicative of lesion‐free survival

Contact Info

Product

Resources

About