Five year follow-up after primary vaccination against tick-borne encephalitis in children

Wittermann, Christoph; Izu, Allen; Petri, Eckhardt; Gniel, Dieter; Fragapane, Elena

doi:10.1016/j.vaccine.2015.02.038

Cited by 20 publications

(12 citation statements)

References 24 publications

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“…Primary vaccination with three doses of GSK TBEvac was highly immunogenic in both adults and children, but the immunological responses in children were generally higher. For all schedules, the GMTs peaked at day 42 (21 days postdose 3 in the rapid group, or 14-28 days post-dose 2 in the conventional-based groups), and then declined to days 180 and 300 (before the third vaccine dose in the conventional series) [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. The percentage of adults with NT titers ≥10 fell from 92% at 21 days to 74% at 279 days post-dose 3 of the rapid schedule [31].…”

Section: Discussionmentioning

confidence: 96%

“…This systematic literature review identified 21 publications reporting the immunogenicity and/or safety of GSK TBEvac [23,24,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46]. We found no articles describing the efficacy or effectiveness of the vaccine, but indirect evidence of protection as provided by immunogenicity results (usually NT titers ≥10) [22] were available for adults and children.…”

Section: Discussionmentioning

confidence: 99%

“…The size of the immunological response post-dose 3 was not reported; it was only generally stated that the response was 'strong' [31]. Such data are however available for childrenand by day 321 (3 weeks after the third dose of vaccine administered by the conventional schedules), all subjects had NT titers ≥10 [39][40][41][42][43][44]. Data generated in children are more the limited and it would Table 6.…”

Section: Discussionmentioning

confidence: 99%

“…Five years post-primary vaccination, 94-98% of all children retained NT titers ≥10, suggesting that an appropriate time interval for first boosting after a conventional/accelerated conventional schedule is 5 years [43].…”

Section: Three-dose Conventional Schedulesmentioning

confidence: 99%

See 3 more Smart Citations

Systematic literature review comparing rapid 3-dose administration of the GSK tick-borne encephalitis vaccine with other primary immunization schedules

Galgani¹,

Bunge²,

Hendriks³

et al. 2017

Expert Review of Vaccines

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Tick-borne encephalitis (TBE), which is endemic across large regions of Europe and Asia, is most effectively prevented through vaccination. Three-dose primary TBE vaccination schedules are either rapid (0,7,21-days) or conventional (0,28-84-days, 9-12-months). The second dose can also be administered at 14 days for faster priming and sero-protection). Areas covered: We used a three-step selection process to identify 21 publications comparing the immunogenicity and/or safety of different schedules. Expert commentary: Priming with two or three TBE vaccine doses was highly immunogenic. After conventional priming (0-28 days), 95% adults and ≥95% children had neutralization test (NT) titers ≥10 at 14 days post-dose-2 compared with 92% adults and 99% children at 21 days post-dose-3 (rapid schedule). Most subjects retained NT titers ≥10 at day 300. A single booster dose induced a strong immune response in all subjects irrespective of primary vaccination schedule or elapsed time since priming. GMT peaked at 42 days post-dose-1 (i.e., 21 days post-dose 3 [rapid-schedule], or 14-28 days post-dose-2 [conventional-schedule]), and declined thereafter. Adverse events were generally rare and declined with increasing doses. In the absence of data to recommend one particular schedule, the regimen choice will remain at the physician's discretion, based on patient constraints and availability.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Three-dose Conventional Schedulesmentioning

confidence: 99%

See 2 more Smart Citations

Systematic literature review comparing rapid 3-dose administration of the GSK tick-borne encephalitis vaccine with other primary immunization schedules

Galgani¹,

Bunge²,

Hendriks³

et al. 2017

Expert Review of Vaccines

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“…Die erste Auffrischimpfung sollte nach 3 Jahren erfolgen. In einer kürzlich publizierten Studie mit Kindern und Jugendlichen bis zu einem Alter von 15 Jahren wurde für Encepur Kinder ® , nicht jedoch für FSME-Immun Junior ® , gezeigt, dass das erste Auffrischintervall möglicherweise von 3 auf 5 Jahre verlängert werden kann [86]. …”

Section: Aktive Immunisierungunclassified

Frühsommermeningoenzephalitis

Kaiser

2016

Nervenarzt

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Tick-borne encephalitis (TBE) is one of the most important viral infections of the human central nervous system. Approximately 10,000 cases of TBE are referred to hospitals in Europe and Asia each year. The TBE virus (TBEV) is mainly transmitted by tick bites but also occasionally by unpasteurized goat's milk. As in endemic areas on average only 1-3 % of ticks are infected with the TBEV and the clinical manifestation rate is approximately 33 %, only approximately 1 in every 100-300 tick bites leads to disease. The incubation period varies from 5-28 days and typically has a biphasic course of fever. The TBE manifests as meningitis in approximately 50 % of patients, as meningoencephalitis in 40 % and as encephalomyelitis in 10 %. The suspected diagnosis is confirmed by the demonstration of TBEV-specific IgM and IgG antibodies in serum and the presence of elevated cell counts in cerebrospinal fluid. No specific treatment for TBE is known but it can be successfully prevented by active immunization.

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Neurotropic Flaviviruses

Johnson¹

2016

Neurotropic Viral Infections

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Five year follow-up after primary vaccination against tick-borne encephalitis in children

Cited by 20 publications

References 24 publications

Systematic literature review comparing rapid 3-dose administration of the GSK tick-borne encephalitis vaccine with other primary immunization schedules

Systematic literature review comparing rapid 3-dose administration of the GSK tick-borne encephalitis vaccine with other primary immunization schedules

Frühsommermeningoenzephalitis

Neurotropic Flaviviruses

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