Five-year exposure to PM2.5 and ozone and subclinical atherosclerosis in late midlife women: The Study of Women's Health Across the Nation

Duan, Chunzhe; Talbott, Evelyn O.; Brooks, Maria M.; Park, Sung Kyun; Broadwin, Rachel; Matthews, Karen A.; Barinas‐Mitchell, Emma

doi:10.1016/j.ijheh.2018.09.001

Cited by 23 publications

(12 citation statements)

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“…To date, most have focused on middle aged and older adults with minimum ages of 45-50 years and/or are non-representative or small, geographically localized samples. Examples include the Multi-Ethnic Study of Atherosclerosis (MESA), 5,56 Atherosclerosis Risk in Communities (ARIC), 57 the Framingham Heart Study, 58 the Jackson Heart Study, 59 the Women's Health Initiative (WHI), 60 and the Study of Women's Health Across the Nation (SWAN), 61 among others. In these cohorts, associations have been observed between exposures to PM2.5 and/or O3 (e.g., >1 year) and: fatal and non-fatal cardiovascular events; 60 diabetes; 62 impaired renal function; 63 systemic inflammation; 58 and arterial injury and subclinical markers of arterial disease that are predictive of coronary heart disease and stroke in individuals without cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Long-term air pollution exposure and markers of cardiometabolic health in the National Longitudinal Study of Adolescent to Adult Health (Add Health) Study

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Fang

Hancock

et al. 2022

Preprint

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Background: Air pollution exposure is associated with cardiovascular morbidity and mortality. Although exposure to air pollution early in life may represent a critical window for development of cardiovascular disease risk factors, few studies have examined associations of long-term air pollution exposure with markers of cardiovascular and cardiometabolic health in young adults. Objectives: By combining health data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) with air pollution data from the Fused Air Quality Surface using Downscaling (FAQSD) archive, we: (1) calculated multi-year estimates of exposure to ozone (O3) and particulate matter with an aerodynamic diameter <2.5um (PM2.5) for Add Health participants; and (2) estimated associations between air pollution exposures and multiple markers of cardiometabolic health. Methods: Add Health is a nationally representative longitudinal cohort study of over 20,000 adolescents aged 12-19 in the United States (US) in 1994-95 (Wave I). Participants have been followed through adolescence and into adulthood with five in-home interviews. Estimated daily concentrations of O3 and PM2.5 at census tracts were obtained from the FAQSD archive and used to generate tract-level annual averages of O3 and PM2.5 concentrations. We estimated associations between average O3 and PM2.5 exposures from 2002-07 and markers of cardiometabolic health measured at Wave IV (2008-09), including hypertension, hyperlipidemia, body mass index (BMI), diabetes, C-reactive protein, and metabolic syndrome. Results: The final sample size was 11,259 individual participants. The average age of participants at Wave IV was 28.4 years (range: 24-34 years). In models adjusting for age, race/ethnicity, and sex, long-term O3 exposure (2002-07) was associated with elevated odds of hypertension, with an odds ratio (OR) of 1.015 (95% confidence interval [CI]: 1.011, 1.029); obesity (1.022 [1.004, 1.040]); diabetes (1.032 [1.009,1.054]); and metabolic syndrome (1.028 [1.014, 1.041]); PM2.5 exposure (2002-07) was associated with elevated odds of hypertension (1.022 [1.001, 1.045]). Conclusion: Findings suggest that long-term ambient air pollution exposure, particularly O3 exposure, is associated with cardiometabolic health in early adulthood.

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Section: Discussionmentioning

confidence: 99%

Long-term air pollution exposure and markers of cardiometabolic health in the National Longitudinal Study of Adolescent to Adult Health (Add Health) Study

Bravo

Fang

Hancock

et al. 2022

Preprint

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“…Accurate estimation of individual exposure to pollutants would help quantify the actual relationship between PM and carotid atherosclerosis. Compared with previous studies [14,19,23], we referred to critical considerations of both the primary predictive model and personal activity patterns. LUR model would re ect the characteristics of long-term pollutant distribution and put in uencing factors of pollutants into consideration [54].…”

Section: Discussionmentioning

confidence: 99%

“…All subgroups tested were identi ed a priori. It was once reported that a greater susceptibility for atherosclerotic lesion of ambient PM were interpreted among individuals with dyslipidemia [14], overweight [16] and hyperuricemia. One possible explanation for this nding is the weaker effects of PM compared with cardiometabolic risk factors on carotid atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…Estimation of individual exposure to PM simply based on monitoring stations would induce great misclassi cation [14,22]. The signi cant association between PM and atherosclerosis disappeared after adjusting for metropolitan area [25], which interprets the implication of spatial characteristics of pollutant distribution.…”

Section: Introductionmentioning

confidence: 97%

“…Association between PM and health-related disease has been explored by animal models and populationbased studies [12][13], but the results were not generally consistent. Long-term exposure to PM was demonstrated as an important risk factor for CIMT in both cross-sectional and longitudinal studies among late midlife women [14] or women transitioning through menopause [15], adolescents or young adults [16], children [17], general population [18,19] and even HIV-positive adolescents [20]. But such association was not found in some other studies for either PM 2.5 [21,22] or PM 10 [16].…”

Section: Introductionmentioning

confidence: 99%

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Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Han

Zhao

et al. 2022

Preprint

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Background Time-location information, including time spent indoors and outdoors around residential and work places and on commuting, physical activity, infiltrated ambient pollution and traffic transportations, was less considered estimating individual exposure to ambient pollution. Studies investigating the association between individual exposure to particulate matter (PM) with aerodynamic diameter <10 μm (PM10) and <2.5 μm (PM2.5) and carotid atherosclerosis obtained inconsistent results. Moreover, combined effect of mixed pollutants on carotid atherosclerosis was not fully explored because of high collinearity. We aimed to investigate the association between long-term individual time-weighted exposure to PM2.5 and PM10 and the risk of carotid atherosclerosis, and further explore the overall effects of multiple pollutants on carotid atherosclerosis. Methods Daily concentration of ambient pollutants was estimated by land-use regression model at both residential and work addresses, and 1-5 years’ time-weighted individual exposure was calculated by further considering personal activity pattern and infiltrated ambient pollution. We explored the association of PM2.5and PM10 with carotid atherosclerosis and pooled the overall effect of multiple pollutants by quantile g-computation. Results The significant association between time-weighted exposure to PM2.5 and PM10and carotid atherosclerosis was observed. Per interquartile range increase in 2-year exposure to PM2.5 (Hazard ratio (HR): 1.322, 95% confidence interval (CI): 1.219-1.434) and PM10 (HR:1.213, 95% CI: 1.116-1.319) showed the strongest association with carotid atherosclerosis, respectively. Individuals in higher quartiles of pollutants were at higher risk for carotid atherosclerosis. The linear and nonlinear relationships interpreted the upward trend of the risk for carotid atherosclerosis with increasing level of pollutant concentrations. Moreover, the overall adverse effects of multiple pollutants were further demonstrated. Conclusions Individual time-weighted exposure to PM2.5, PM10 and mixed pollutants was associated with carotid atherosclerosis. It is necessary to reduce individual pollutant exposure to inhibit the risk of carotid atherosclerosis and subsequently alleviate disease burdens of atherosclerotic diseases.

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Women’s Midlife Health

Dias¹,

Subu²,

Abraham³

et al. 2020

Handbook of Global Health

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Five-year exposure to PM2.5 and ozone and subclinical atherosclerosis in late midlife women: The Study of Women's Health Across the Nation

Abstract: Long-term exposure to PM may contribute to elevated risk of atherosclerosis in the post-menopausal period.

Cited by 23 publications

References 53 publications

Long-term air pollution exposure and markers of cardiometabolic health in the National Longitudinal Study of Adolescent to Adult Health (Add Health) Study

Long-term air pollution exposure and markers of cardiometabolic health in the National Longitudinal Study of Adolescent to Adult Health (Add Health) Study

Associations of Time-Weighted Individual Exposure to Ambient Particulate Matter with Carotid Atherosclerosis in Beijing, China

Women’s Midlife Health

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