Five-year cancer cure: Relation to total amount of peripheral lymphocytes and neutrophils

Riesco, A

doi:10.1002/1097-0142(197001)25:1<135::aid-cncr2820250120>3.0.co;2-9

Cited by 185 publications

(79 citation statements)

References 7 publications

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“…In general, SIR reflects a local and systematic chronic inflammation, which could be caused by various types of malignancies. Riesco et al initially reported the relationships between SIR and blood lymphocyte, monocyte, and platelet counts 22 . The Glasgow prognostic score, reported by Forrest et al for non-small-cell lung cancer, is widely known as an indicator of SIR 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several reports have indicated that the state of the Systemic Inflammatory Response (SIR) provides significant information about the prognoses of a variety of cancers [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] . Neutrophil-lymphocyte ratio (NLR), which reflects SIR, has been reported as a prognostic factor in gastrointestinal cancers, including intrahepatic cholangiocarcinoma 19 and colorectal cancer 20 .…”

Section: Introductionmentioning

confidence: 99%

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A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma

Saito

Noji

Okamura

et al. 2016

Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma

Saito

Noji

Okamura

et al. 2016

Surgery

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“…Lymphopenia is common in advanced malignant disease and is an adverse prognostic indicator. 34 It may be induced or exacerbated by conventional chemotherapy and radiotherapy. In an in vivo MLR experiment, however, it was found that at the peak of MLR following injection of allogeneic cells, more than 20% of the host lymph node cells were IL-2 receptor (IL-2R) positive and the majority of these were Lyt-2 1 T cells and B cells.…”

Section: Discussionmentioning

confidence: 99%

A simple and effective method for cancer immunotherapy by inactivated allogeneic leukocytes infusion

Guo

Zhou

et al. 2008

Intl Journal of Cancer

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Allogeneic mixed leukocytes reaction has been reported to activate vast numbers of T lymphocytes and produce large amounts of type 1 cytokines that are linked to an initiation of antitumor immunity. Using poor immunogeneic B16-F10 and Lewis lung carcinoma (LLC) tumor model, we evaluated the effects of inactivated allogeneic leukocytes infusion (ALI) on the generation of antitumor immune response, as well as its effect on the primary and metastatic tumor. Allogeneic response promoted the generation of both specific and nonspecific antitumor immunity in an in vitro mixed lymphocytes-tumor cell culture system. Introveinous infusion of mitotically inactivated allogeneic leukocytes resulted in increased type-1 cytokines (including IL-2 and IFN-c) release, proliferation of various lymphocyte subsets, and generation of both specific and nonspecific antitumor immune response. As a result of such immune response, ALI caused a delayed tumor growth and a prolonged survival in established B16-F10 melanoma model. In LLC pulmonary spontaneous metastases model, ALI treatment significantly reduced postoperative tumor metastasis as the lung weights were far smaller than control group (0.16 vs. 0.34 g). Furthermore, after primary tumor resection and ALI treatment, 62.5% mice obtained long-term survival (>120 days) and there were no tumor growths in these mice when they were rechallenged with the same tumor. These experiments demonstrate that inactivated ALI could activate innate and adoptive antitumor immune response. It would be a simple, effective and secured method for cancer immunotherapy. ' 2008 Wiley-Liss, Inc.Key words: cancer; immunotherapy; alloantigen; metastasis Allogeneic transplantation (including heametopoietic stem cell transplantation) has been used as a successful therapeutic modality for various diseases, including malignancies. 1 Nevertheless, there is always a major limitation in the allogeneic transplantation: either host vs. graft (HVG) or graft vs. host (GVH). With a clear manifestation of the mechanisms of transplantation immunology, it is well recognized that alloantigen, a potent immunostimulator, elicits strong and rapid cellular and humoral immune responses, plays a key role in HVG or GVH. However, both HVG and GVH biology share several mechanisms that contribute to antitumor effects that occur outside of allogeneic transplantation, including IFN-g secreting type 1 T cells, 2 antigen presenting cells (APCs) activation, 3 and fas-and perforin-based cytolysis. 4 Therefore, it is possible to harness these characteristics as a therapeutic modality for malignancy.Actually, hematopoietic stem-cell transplantation (HSCT) is under study as a immunotherapeutic modality and achieve considerable effect in a wide range of hematologic and nonhematologic malignancies. 1,5 The basis of this treatment rests on an immune mechanism called the graft-versus-leukemia or graft-versus-tumor effect. Presumably, alloreactive T cells (CD4 and CD8 T cells) in the allograft participate in these phenomena, but the relevant antige...

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“…Already in 1970, Riesco [366] observed a positive correlation between cancer curability and the total number of lymphocytes, while a negative correlation was found with the total number of peripheral neutrophils (segmented and nonsegmented) when 589 cases of different cancer types were investigated. From then on, a large number of clinical studies have been performed to understand the neutrophil-cancer relationship.…”

Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

339

261

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Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

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Five-year cancer cure: Relation to total amount of peripheral lymphocytes and neutrophils

Cited by 185 publications

References 7 publications

A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma

A new prognostic scoring system using factors available preoperatively to predict survival after operative resection of perihilar cholangiocarcinoma

A simple and effective method for cancer immunotherapy by inactivated allogeneic leukocytes infusion

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

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