Five undescribed steroids from Talaromyces stipitatus and their cytotoxic activities against hepatoma cell lines

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

“…A number of ergosterol metabolites including hydroxyketones 91, 93, 109 were isolated from a non-pathogenic filamentous fungus Talaromyces stipitatus [ 204 ]. Compounds 91, 93, 109 showed remarkable cytotoxic activities against hepatoma cell lines with IC 50 values ranging down to 5.26 μM.…”

Research advances in the structures and biological activities of secondary metabolites from Talaromyces

“…A new withanolide, talasteroid (178) was obtained from rice culture of the marinederived fungus T. stollii HBU-115 (Zhang et al, 2022c). Five undescribed sterol derivatives (179-183), (22E,24R)-7αmethoxy-5α,6α-epoxyergosta-8( 14), 22-diene-3β,15β-diol, (22E,24R)-5α,6α-epoxyergosta-8(14),22-diene-3β,7β,15α-triol, (22E,24R)-3β,5α-dihydroxy-14β,15β-epoxyergosta-7,22-diene-6-one, (22E,24R)-6α-methoxy-7α,15β-dihydroxyergosta-4,8(14),22-triene-3-one, and (25S)-ergosta-7,24(28)-diene-3β,4α,6α,26-tetraol were isolated from the extract of T. stipitatus (Zhang et al, 2021). The antiproliferative activities of compound 179-183 were mainly mediated by inducing cell apoptosis.…”

Ergone Derivatives from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10 and 25,28-Dihydroxyergone-Induced Apoptosis in Human Colon Cancer SW620 Cells

“…To the best of our knowledge, about 20 ergone derivatives have been reported from filamentous fungi (Figure S1). − Extensive chromatographic separations of this fraction were performed to search for ergone derivatives with cytotoxicity to the SW620 cell line, resulting in the identification of ten new ( 1 – 10 ) and five known ergone derivatives ( 11 – 15 ). The structures are characterized by a 25-hydroxy-ergone (25-hydroxyergosta-4,6,8(14),22-tetraen-3-one) nucleus with varying degrees of oxidation at C-12, C-15, C-26, or C-28 to generate alcohols, some of which were further acetylated or methylated.…”