Five Tetramic Acid Derivatives Isolated from the Iranian Fungus Colpoma quercinum CCTU A372

Primahana, Gian; Narmani, Abolfazl; Surup, Frank; Teponno, Rémy Bertrand; Arzanlou, Mahdi; Stadler, Marc

doi:10.3390/biom11060783

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…All media were supplemented with 10% fetal bovine serum (FBS; Gibco) and incubated under 5% CO 2 at 37 °C for 5 days. The cytotoxicity assay was performed using the MTT (3-(4,5-dimethylthiazol-2-yl)-2, 5 diphenyltetrazolium bromide) test in 96-well microplates in accordance with our standard protocol which have been well previously described [ 23 , 24 , 25 ]. Methanol was used as negative control, and epothilone B as the positive control.…”

Section: Methodsmentioning

confidence: 99%

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

2021

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In the search for novel anti-infectives from natural sources, fungi, in particular basidiomycetes, have proven to still harbor so much potential in terms of secondary metabolites diversity. There have been numerous reports on isolating numerous secondary metabolites from genus Laetiporus. This study reports on two new triterpenoids, laetiporins C and D, and four known triterpenes from the fruiting body of L. sulphureus. The structures of the isolated compounds were elucidated based on their 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. Laetiporin C exhibited weak antifungal activity against Mucor hiemalis. Furthermore, the compounds showed weak antiproliferative activity against the mouse fibroblast L929 and human cancer cell lines, including KB-3-1, A431, MCF-7, PC-3 and A549.

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Section: Methodsmentioning

confidence: 99%

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

2021

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“…The in vitro cytotoxicity (IC 50 ) of the isolated metabolites except compounds 3 and 12 against several mammalian cell lines (human endocervical adenocarcinoma KB 3.1, breast cancer MCF-7, lung cancer A549, ovary cancer SK-OV-3, prostate cancer PC-3, squamous cancer A431, and mouse fibroblasts L929) was determined by a colorimetric tetrazolium dye MTT assay using epothilone B as a positive control in accordance to our previously reported experimental procedure. , A detailed protocol can be found in the SI.…”

Section: Methodsmentioning

confidence: 99%

Terpenoids and Meroterpenoids from Cultures of Two Grass-Associated Species of Amylosporus (Basidiomycota)

et al. 2022

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An investigation of the chemical components of the fermentation extract of two cultures of Amylosporus cf. graminicola and Amylosporus cf. campbelii from Cuba and Zimbabwe, respectively, led to the isolation of seven previously undescribed secondary metabolites for which we proposed the trivial names amylosporanes A−G (1−7) along with the known compounds orsellinic acid (11), colletorin D acid (12), colletorin B (13), colletochlorin B ( 14), and the β-lactam cyclo-(S-Pro-R-Leu) (15). Three additional compounds (8−10) previously unknown from a fungal source were also characterized for the first time, and two of them were assigned the trivial names amylosporanes H−I (8−9) while the other was identified as cannabigerorcinic acid (10). The structures of the isolated compounds were determined based on their high-resolution electrospray ionization mass spectrometry (HR-ESIMS) spectra and an extensive analysis of their 1D and 2D NMR spectroscopic data. Based on literature searches, we hypothesized that a majority of the isolated metabolites have orsellinic acid (11) as a biosynthetic precursor following a combined route of mevalonate-associated and orsellinic acid-associated pathways. Colletochlorin B ( 14), the only compound possessing chlorine in its structure, exhibited significant activity against Bacillus subtilis (minimum inhibitory concentration, 2 μg/mL), stronger than that of oxytetracycline, and significant cytotoxicity against A431 cells with an IC 50 value of 4.6 μM.

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Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi

Kim,

Lee,

Shim

2024

Nat. Prod. Rep.

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Five Tetramic Acid Derivatives Isolated from the Iranian Fungus Colpoma quercinum CCTU A372

Cited by 4 publications

References 34 publications

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

Two New Triterpenes from Basidiomata of the Medicinal and Edible Mushroom, Laetiporus sulphureus

Terpenoids and Meroterpenoids from Cultures of Two Grass-Associated Species of Amylosporus (Basidiomycota)

Biosynthesis, biological activities, and structure–activity relationships of decalin-containing tetramic acid derivatives isolated from fungi

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