Five Primary Synchronous Neoplasms of the Gastrointestinal Tract

Abstract

Multiple primary malignant neoplasms in a single patient have been well documented in the literature over the past hundred years. The lesions can be limited to a single organ or involve multiple organ systems. It is relatively common for patients with colorectal carcinoma or carcinoid tumors to have more than one primary neoplasm. Colonic lesions can be synchronous or metachronous in presentation and colonic or extracolonic in location. We present a patient with five primary synchronous neoplasms of the gastrointestinal tract, involving the stomach, small bowel, and colon. The patient had no evidence of metastatic disease and underwent resection of all the lesions. This case illustrates the need for a thorough search for additional neoplasms in the treatment of patients with cancer.

Cancers primitifs multiples de la thyroïde et du côlon : à propos d’un cas et revue de littérature

“…Les séries autopsiques rapportent des taux plus élevés allant jusqu'à 36 % [11]. Cette grande variation dans la prévalence des cancers primitifs multiples pourrait être attribuée à plusieurs facteurs tels que l'année et les critères de diagnostic des CPM, les caractéristiques des patients et les critères de sélection des cas d'autopsie [12].…”

Clinical presentation, endoscopic features, treatment and prognosis of synchronous upper gastrointestinal malignancies

“…The simultaneous presence of two or more primary malignancies was once regarded as rare, but is a well recognized situation currently. However, reports on synchronous upper GI malignancies are scarce: most are case reports or small case series that included both upper and lower GI malignancies 4,6,11–13 …”

Neoplasias primárias múltiplas em pacientes com câncer colorretal

“…A prevalência estimada de neoplasias primárias múltiplas varia muito em cada série, pois não existe padronização na forma das pesquisas, critérios de inclusão e de registro. Desde a primeira descrição até hoje, aumentaram muito as publicações sobre este tema; um dos motivos seria o melhor e mais cuidadoso acompanhamento dos pacientes, e o outro, o aumento de sua incidência (3,8,15) .…”

“…Entre as causas de NPM e o aumento de sua incidência, estão o aumento da sobrevida, fatores hereditários, efeito carcinogênico e imunossupressor da terapia empregada, e a fatores de risco a que o paciente esteve exposto (por exemplo: álcool, tabaco) (3,5,8,15) .…”