Five Polymorphisms of the Apolipoprotein B Gene in Healthy Bulgarians

Horvath, Anélia; Chorbov, Vesselin M.; Zaharova, Boriana; Ganev, Varban

doi:10.1353/hub.2003.0022

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…The genotype frequencies reported in this cohort were found to be similar to other reports. For example, the observed frequencies for the APOB signal peptide polymorphism (D : 0.23, I : 0.77) for the control group ( n = 363) were similar to those reported in other populations [ 26 , 30 , 46 , 47 ]. The observed frequencies for the CHD patients ( n = 372) (D : 0.32, I : 0.68) were also similar to those for the CHD patients reported for other populations [ 48 ].…”

Section: Discussionsupporting

confidence: 86%

Increased Risk of theAPOBrs11279109 Polymorphism for CHD among the Kuwaiti Population

et al. 2017

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Background Coronary heart disease (CHD) is among the leading causes of death in Kuwait. This case-control study investigated the genetic association of APOB rs11279109 with CHD in Kuwaitis. Methods The polymorphism was genotyped in 734 Kuwaiti samples by direct amplification. Statistical analysis with genetic modeling was used to assess its association with CHD. Results A statistically significant association (P < 0.001) between the rs11279109 DD genotype (OR: 2.43, CI: 1.34–4.41) with CHD was observed. A codominant genetic model revealed a 2.69 risk increase (CI: 1.57–4.61) for the DD genotype (P = 0.009) independent of age, sex, BMI, smoking, hypercholesterolemia, and ethnicity suggesting APOB rs11279109 as an indicator for the increased risk of CHD. Conclusion The DD genotype may explain molecular mechanisms that underline increased LDL oxidation leading to arthrosclerosis. The findings emphasize the need to identify genetic markers specific to the CHD patient ethnic group in order to improve prognosis and help in early diagnosis and prevention.

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Section: Discussionsupporting

confidence: 86%

Increased Risk of theAPOBrs11279109 Polymorphism for CHD among the Kuwaiti Population

et al. 2017

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“…The allele and genotype frequencies at the APOB gene locus have been studied and reported for numerous populations including Northern Europeans [ 27 – 29 ], Southern Europeans [ 19 , 29 , 30 ], Asians [ 22 , 25 , 31 , 32 ] and others [ 33 – 36 ]. However, no such frequencies have ever been reported for the Kuwaiti population.…”

Section: Introductionmentioning

confidence: 99%

Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population

et al. 2014

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BackgroundSeveral studies have identified APOB as a candidate gene predisposing individuals to dyslipidemia. Polymorphisms including the signal peptide (rs11279109), codon 2488 XbaI (rs1042031), codon 3611 MspI (rs693), codon 4154 EcoRI (rs1801701) and the 3’ variable number of tandem repeats have been reported to be associated with dyslipidemia in several populations. With limited studies on Arabs, this study aimed to investigate the genetic association of APOB polymorphisms and assess the potential influence of minor and rare alleles on serum lipid levels in the Kuwaiti population.MethodsA total of 795 Kuwaiti subjects, documented with phenotypic data and fasting serum lipid levels, were genotyped for the five polymorphisms using PCR, PCR-RFLP and gene fragment analysis. Genotype and allele association with variation in serum lipid levels as well as haplotypes were analyzed using chi-square test, univariate and logistic regression analysis.ResultsAnalysis of the genotype and allele frequencies distribution revealed a significant positive association between the APOB signal peptide and 3611 MspI polymorphisms with increased levels of triglycerides (statistical power of 80%). Haplotype analysis further supported the findings by showing that carriers of haplotypes (IX−M−E+M) had significantly lower mean (SD) TG levels (0.86 ± 0.07) as compared to non-carriers (1.01 ± 0.02). Significance was also observed with regards to positive family history of hypercholesterolemia.ConclusionThe results imply a “protective role” for two alleles (rs11279109 and rs1801701) in which logistic regression analysis showed a significant half–fold decrease in the risk for heterozygotes of rs11279109 and an 8.8 fold decrease in the risk for homozygous M−M− of rs1801701 of having lower TG levels (<1.70 mmol/L) in individuals. This suggests that genetic interaction between various polymorphisms at different gene loci act in linkage disequilibrium to affect serum TG levels. Apo B genotyping may be a useful adjunct for the identification of individuals at risk of developing dyslipidemia in order to provide them with lifestyle modifications and/or pharmacological intervention to mitigate the effects of gene interaction and environmental influence.Electronic supplementary materialThe online version of this article (doi:10.1186/1476-511X-13-157) contains supplementary material, which is available to authorized users.

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“…It is noteworthy that the XbaI polymorphism was related to the inter-individual variability observed during postprandial lipemia, showing a signifi cantly augmented or reduced postprandial response ( 261,262 ). Particularly, a variable number of tandem repeats polymorphism, which is located 75 bp downstream of the second polyadenylation signal at the 3 ′ end of the Apo B gene (2p24-p23), has been found to be common in some ethnic groups (263)(264)(265)(266). They were associated with modifi cations of lipid concentrations (267)(268)(269)(270)(271) and the risk of coronary heart diseases ( 270-272 ).…”

Section: Discussionmentioning

confidence: 99%

Insights from human congenital disorders of intestinal lipid metabolism

Lévy

2015

Journal of Lipid Research

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Five Polymorphisms of the Apolipoprotein B Gene in Healthy Bulgarians

Cited by 10 publications

References 35 publications

Increased Risk of theAPOBrs11279109 Polymorphism for CHD among the Kuwaiti Population

Increased Risk of theAPOBrs11279109 Polymorphism for CHD among the Kuwaiti Population

Genetic association of APOB polymorphisms with variation in serum lipid profile among the Kuwait population

Insights from human congenital disorders of intestinal lipid metabolism

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