Five patients with severe burns and refractory infections treated using the traditional Japanese medicine juzentaihoto

Nakae, Hajime; Yokoi, Aya; Kato, Masayuki; Akama, Tomonori; Yamakawa, Takehiro; Manabe, Motomu; Hasunuma, Naoko

doi:10.1016/j.pmu.2013.04.005

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Karibe et al (1997) reported that the administration of Kampo medicines, HET and juzentaihoto, significantly reduced the rate of MRSA among MRSA carriers in the neurosurgery unit. Nakae et al (2013) also reported that juzentaihoto administration led to negative bacterial cultures in five patients with refractory multidrug-resistant bacterial infections, including MRSA, with severe burns. In an experimental study, Matsushima et al (2012) reported that The odds ratios and p-values are the results of binary logistic regression analyses using the detection of MRSA colonization as the objective variable.…”

Section: Discussionmentioning

confidence: 95%

Hochuekkito can Prevent the Colonization of Methicillin-Resistant Staphylococcus aureus in Upper Respiratory Tract of Acute Stroke Patients

Kitahara¹,

Takayama

Akaishi

et al. 2021

Front. Pharmacol.

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Background: Methicillin-resistant Staphylococcus aureus (MRSA) colonization can lead to MRSA pneumonia or other infections in compromised hosts, and invasive MRSA infections lead to significant morbidity and mortality. The present observational study elucidated whether administration of hochuekkito (HET) can prevent MRSA colonization in the upper respiratory tract and support recovery in acute stroke patients.Methods: In this retrospective, observational study, 73 acute stroke patients admitted to Kenwakai Hospital between April 2007 and December 2019 who did not require emergency surgery during this period were enrolled. Conventional treatment was provided to all patients, depending on their condition, and 7.5 g/day of HET was administered to the patients who could take the medicine via nasogastric tube or orally in three divided doses for three months. Bacterial cultures from laryngeal swabs and sputum were evaluated every week. We evaluated the presence of MRSA infection or another infectious disease within 30 days of admission; modified Rankin Scale scores, which assesses the independent living skills after stroke at three months after admission; and blood biomarkers (white blood cell count, albumin levels, C-reactive protein levels, and hemoglobin levels).Results: In total, 73 patients (HET group, n = 41; non-HET group, n = 32) were enrolled in the study. MRSA detection was significantly less likely in the HET group than in the non-HET group (p = 0.0497). The incidence of infectious diseases was significantly lower in the HET group than in the non-HET group (p = 0.0096), and the modified Rankin Scale score at three months was also significantly lower in the HET group than in the non-HET group (p = 0.033). The white blood cell count, and serum C-reactive protein levels did not differ between those who were treated with HET and those who were not. However, serum albumin and hemoglobin levels improved slightly between month one and month three after admission only in those who were treated with HET.Conclusion: Our results indicate that the administration of HET may contribute to the prevention of MRSA colonization and promote rehabilitation in stroke patients.

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Section: Discussionmentioning

confidence: 95%

Hochuekkito can Prevent the Colonization of Methicillin-Resistant Staphylococcus aureus in Upper Respiratory Tract of Acute Stroke Patients

Kitahara¹,

Takayama

Akaishi

et al. 2021

Front. Pharmacol.

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“…For these reasons, it would seem difficult to apply these traditional treatment approaches in emergency medicine. Nevertheless, use of Kampo extracts is gradually increasing in clinical settings . However, it should be examined whether and how different concentrations of BDG and ETX in Kampo extracts affect patients.…”

Section: Discussionmentioning

confidence: 99%

Determination of β‐d‐glucan and endotoxin levels in Kampo extracts

Nakae

Takahashi

Sato

et al. 2014

Acute Medicine & Surgery

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Aims: Kampo medicine is based on the use of established formulations combining natural extracts with no "brand-name" products or corresponding "generic" formulation. Due to differences in manufacturing practices, products of different pharmaceutical companies may contain different concentrations of β-D-glucan and endotoxins. The aim of this study was to compare the concentrations of β-D-glucan and endotoxins in five Kampo extracts from four pharmaceutical companies.Methods: Packages of Kampo extracts were dissolved in distilled water. β-D-Glucan and endotoxin concentrations were measured using high-sensitivity kinetic turbidimetric Limulus assay.Results: All Kampo extracts examined in this study were found to contain detectable concentrations of β-D-glucan and endotoxins.Significant differences in the concentration of β-D-glucan and endotoxins (P = 0.0024 and P = 0.0013, respectively) were observed between products of different pharmaceutical companies. Conclusions:High β-D-glucan and endotoxin contents were detected in Kampo extracts, with a large variability in the concentrations of both β-D-glucan and endotoxins among extracts from different pharmaceutical companies.

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“…Matsui et al 12 reported that HET could inhibit MRSA growth and extend the survival time of MRSA-infected mice. Nakae et al reported that juzentaihoto (JTT) led to negative bacterial cultures in five cases of refractory multidrug-resistant bacterial infection, including a MRSA case with severe burns 13 . These studies indicated that HET and JTT could be effective for reducing MRSA colonization.…”

Section: Introductionmentioning

confidence: 99%

A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci

Kohno

Kawamura

Kikuchi

et al. 2021

Sci Rep

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Vancomycin-resistant enterococci (VRE) are prominent causes of nosocomial infections. Japanese traditional (Kampo) medicine promotes intestinal immunity and protects against bacterial infections. We assessed potential differences in the clinical course of VRE-positive patients, based on their characteristics and treatment with Kampo medicines. This retrospective observational study collected data from VRE-positive patients from August 2018 to July 2019 at a tertiary-care hospital in Japan. The data of 122 consecutive VRE-positive inpatients were analyzed. Sixty-nine patients were treated with probiotics, among whom, 18 were further treated with Kampo medicines. Twenty-six of the 122 patients subsequently died. In univariate analyses, subsequent VRE negative conversion significantly reduced the mortality of VRE-detected patients (p = .0003). Administration of probiotics (p = .0065) and Kampo medicines with probiotics (p = .0002), especially of the Kampo medicine hochuekkito (p = .0014), and a higher serum albumin level positively contributed to the subsequent VRE negative conversion. Multivariate analyses demonstrated that Kampo medicines and body mass index contributed to VRE negative conversion. Hochuekkito shortened the time needed for VRE negative conversion (p = 0.0485). Administration of Kampo medicines, especially of hochuekkito, in addition to probiotics in VRE patients may promote VRE negative conversion.

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Five patients with severe burns and refractory infections treated using the traditional Japanese medicine juzentaihoto

Cited by 7 publications

References 21 publications

Hochuekkito can Prevent the Colonization of Methicillin-Resistant Staphylococcus aureus in Upper Respiratory Tract of Acute Stroke Patients

Hochuekkito can Prevent the Colonization of Methicillin-Resistant Staphylococcus aureus in Upper Respiratory Tract of Acute Stroke Patients

Determination of β‐d‐glucan and endotoxin levels in Kampo extracts

A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci

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