Five organotin complexes derived from hydroxycinnamic acid ligands: Synthesis, structure, in vitro cytostatic activity and binding interaction with BSA

Su, Hui-Qian; Zhang, Rufen; Guo, Qiang; Wang, Jing; Li, Qianli; Du, Xiu‐Mei; Ru, Jing; Zhang, Qingfu; Ma, Chunlin

doi:10.1016/j.molstruc.2021.131290

Cited by 6 publications

(1 citation statement)

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“…This result is expected, as hydrogen atoms are part of oxoquinoline and methyl groups. The interactions between the oxygen atom of carbonyl, the carboxyl group and the hydrogen atom are present with 27.8%, similar to the compounds in reference [29]. Conventional hydrogen bonds are included in this group [30].…”

Section: Hirshfeld Surface Analysismentioning

confidence: 79%

Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells

Kasalović,

Dimić,

Jelača

et al. 2024

Pharmaceuticals

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A novel trimethyltin(IV) complex (Me3SnL), derived from 3-(4-methyl-2-oxoquinolin-1(2H)-yl)propanoate ligand, has been synthesized and characterized by elemental microanalysis, UV/Vis spectrophotometry, FT-IR and multinuclear (1H, 13C and 119Sn) NMR spectroscopies. Furthermore, the structure of the ligand precursor HL was solved using SC-XRD (single-crystal X-ray diffraction). The prediction of UV/Vis and NMR spectra by quantum-chemical methods was performed and compared to experimental findings. The protein binding affinity of Me3SnL towards BSA was determined by spectrofluorometric titration and subsequent molecular docking simulations. Me3SnL has been evaluated for its in vitro anticancer activity against three human cell lines, MCF-7 (breast adenocarcinoma), A375 (melanoma) and HCT116 (colorectal carcinoma), and three mouse tumor cell lines, 4T1 (breast carcinoma), B16 (melanoma) and CT26 (colon carcinoma), using MTT and CV assays. The strong inhibition of A375 cell proliferation, ROS/RNS upregulation and robust lipid peroxidation lead to autophagic cell death upon treatment with Me3SnL.

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Section: Hirshfeld Surface Analysismentioning

confidence: 79%